Rchr

J-GLOBAL ID：200901024789235087 Update date: Jan. 30, 2024

Ohara Naoya

オオハラナオヤ | Ohara Naoya

Affiliation and department：
Job title： Professor

Research field (2)： Bacteriology , Oral medicine

Research keywords (2)：病原細菌 , pathogenic bacteria

Research theme for competitive and other funds (42)：

2023 - 2027 細菌の酵素反応を基盤とした根面う蝕管理法の開発
2021 - 2026 Molecular mechanism of host cell response disruption and periodontal tissue destruction by proteases produced by periodontal bacteria
2020 - 2023 アルカリ産生性アクチノマイセス属細菌を応用したう蝕管理法の確立
2019 - 2022 Elucidation of biofilm formation mechanism via signal transduction system of mycobacteria
2017 - 2022 The mechanism of periodontal tissue destruction by proteases from periodontal bacteria Porpyromonas gingivalis.

2017 - 2021 Understanding the pathogenicity of periodontal disease onset and systemic disease exacerbation caused by periodontal bacteria

2016 - 2018 Analysis the virulence of Mycobacterium tuberculosis based of rapid-growing BCG

2015 - 2018 Effects of Multilineage-differentiating stress-enduring (Muse) cells on brain damages induced by Shiga toxin 2 in vivo and in vitro

2015 - 2018 Development of a novel root caries treatment by bacterial inactivation factor

2014 - 2017 Molecular mechanisms of periodontal diseases and systematic diseases associated with periodontal diseases by periodontal pathogens

2014 - 2017 Development of new periodontal disease prevention method using ECF sigma factors of periodontal pathogenic bacteria

2013 - 2016 Analysis of mechanism of T cell targeting into Mycobacterium tuberculosis-infected lung and development of new lung-targeting vaccine strategy

2012 - 2015 TraSH法による歯周病原細菌の宿主細胞内防御系からの回避機構の解明

2012 - 2015 Kinetic analysis of cariogenic bacteria on root dentin caries

2012 - 2015 Molecular imaging analysis of the antitumour activity of 5-fluorouracil combine with Mycobacterium bovis bacillus Calmette-Guérin (BCG) in the mouse oral cancer model.

2012 - 2014 The application of bacterial biomineralization to sealed restoration

2011 - 2013 receptor

2010 - 2012 Study on the survival strategies for periodontal bacteria in host cells and their role in the pathogenesis of periodontal diseases

2010 - 2012 Investigation on the automation and speeding up ofmeasurement of the plasma IgG antibody titers against periodontopathic bacteria

2010 - 2012 Development of prevention and treatment methods for infection by enterohemorrhagic Escherichia coli O157 based on bio-protect ive mechanisms

2006 - 2009 The study of the mechanism of therapeutic efficacy of novel vaccines on Tuberculosis-infection and the induction of cytotoxic T cells by the vaccines

2007 - 2008 Analysis of molecular mechanism of bone metabolism disruption by bacterial infection

2007 - 2008 Hydrogen Sulfide Production from Cysteine and Homocysteine by Periodontal and Oral Bacteria

2006 - 2007 Study for gignipain-related adhesins of Periodontal pathogen, Porphyromonas gingivalis for its platelet aggregation activity

2005 - 2007 Molecular Mechanisms of Interaction between Periodontitis and Cardiovascular and Bone Metabolic Disorders

2005 - 2005 P.gingivalisの生体内環境における病原性発現調節機構の解析

2004 - 2005 口腔慢性細菌感染の心血管系および骨代謝系への影響とその病原因子に関する研究

2004 - 2005 Study on the oxidative stress responses of a major periodontopathogenic bacteria

2002 - 2004 Pest-sequencing analysis of periodontal pathogen Porphyromonas gingivalis : expression of its proteins by oral environmental fectors.

2002 - 2004 Establishment of Novel (DNA-recombinant BCG-, and fusion protein-)vaccination against Tuberculosis and analysis of novel differentiation mechanism of cytotoxic T cell

2003 - 2003 歯周病原細菌菌体表面タンパクの心血管系および骨代謝系に及ぼす影響

2001 - 2003 Investigation of New Drugs that Inhibit Acquisition of Iron from Oral Environments in the Periodontopathogen Porphyromonas gingivalis.

2001 - 2002 Identification of HLA-restricted cytotoxic T cell epitopes of Mycobcaterium tuberculosis for developing epitope vaccines

1999 - 2000 歯周病原細菌における低分子ストレスタンパク質による広範囲調節機構の解析

1997 - 2000 A study for non-specific or specific immunochemotherapy by using recombinant BCG

1998 - 1998 マラリアのワクチン開発を目指した,BCGからのSERA抗原発現の試み

1997 - 1998 歯周疾患関連菌に新しく発見された挿入配列の病原性への関与

1997 - 1998 う蝕の遺伝子治療に関する基礎的研究

1995 - 1995 歯周病関連菌リボゾーム画分に存在する免疫活性物質の研究

1994 - 1994 歯周病関連菌のリボゾーム蛋白質の歯周疾患発症における意義

1992 - 1994 Studies for the Development of Recombinant BCG and for the Structure and Function of Secreting Proteins in Mycobacteria

1991 - 1991 歯周病発病の分子機構の研究(口腔細菌のストレス蛋白質遺伝子の構造と機能)

Show all

Papers (131)：

中山真彰, 内藤真理子, 中山浩次, 大原直也. Porphyromonas gingivalisジンジパインによるphospholipase Cの活性化と歯周組織の炎症との関連性. Journal of Oral Biosciences Supplement. 2023. 2023. [P3-32]
Amina K Shaban, Gebremichal Gebretsadik, Mariko Hakamata, Hayato Takihara, Erina Inouchi, Akihito Nishiyama, Yuriko Ozeki, Yoshitaka Tateishi, Yukiko Nishiuchi, Takehiro Yamaguchi, et al. Mycobacterial DNA-binding protein 1 is critical for BCG survival in stressful environments and simultaneously regulates gene expression. Scientific reports. 2023. 13. 1. 14157-14157
中山真彰, 山口智之, 内藤真理子, 中山浩次, 大原直也. Porphyromonas gingivalisジンジパインによるPLCを介したCOX-2発現とPGE2産生の分子機序. 日本細菌学雑誌. 2023. 78. 1. 88-88
Shoichi Mitsunaka, Kohei Yamazaki, Ajeng K. Pramono, Megumi Ikeuchi, Tomoe Kitao, Naoya Ohara, Tomoko Kubori, Hiroki Nagai, Hiroki Ando. Synthetic engineering and biological containment of bacteriophages. Proceedings of the National Academy of Sciences. 2022. 119. 48. e2206739119
中山真彰, 内藤真理子, 中山浩次, 大原直也. Porphyromonas gingivalisジンジパインによるCOX-2発現とPGE2産生におけるホスホリパーゼの役割(The role of phospholipase on Porphyromonas gingivalis gingipains-induced COX-2 expression and PGE2 production). Journal of Oral Biosciences Supplement. 2022. 2022. 219-219

ｍore...

MISC (175)：

中山真彰, 中山真彰, 内藤真理子, 中山浩次, 大原直也, 大原直也. Porphyromonas gingivalisジンジパインによるphospholipase Cの活性化と歯周組織の炎症との関連性. Journal of Oral Biosciences Supplement (Web). 2023. 2023
中山真彰, 中山真彰, 山口智之, 内藤真理子, 中山浩次, 大原直也, 大原直也. Porphyromonas gingivalis gingipains induce COX-2 expression and PGE2 production via phospholipase C. 日本細菌学雑誌(Web). 2023. 78. 1
佐藤あやめ, 佐藤あやめ, 中山真彰, 藤井伸治, 松岡賢市, 前田嘉信, 和田崇之, 曽我賢彦, 大原直也. Isolation and detection methods for Lautropia mirabilis and analysis of drug susceptibility. 日本細菌学雑誌(Web). 2022. 77. 1
中山真彰, 内藤真理子, 中山浩次, 大原直也, 大原直也. Role of calcium channels in COX-2 expression and PGE2 production by gingipains. 日本細菌学雑誌(Web). 2022. 77. 1
中山真彰, 中山真彰, 内藤真理子, 中山浩次, 大原直也, 大原直也. The role of phospholipase on Porphyromonas gingivalis gingipains-induced COX-2 expression and PGE2 production. Journal of Oral Biosciences Supplement (Web). 2022. 2022

ｍore...

Books (11)：

BCG : TB vaccine : application against tuberculosis and other diseases
JATA 2022 ISBN:9784874513224
口腔微生物学・免疫学第5版
2021
シンプル微生物学改訂第6版
南江堂 2018 ISBN:9784524254835
結核改訂版
医薬ジャーナル社 2017
口腔微生物学・免疫学第4版
医歯薬出版 2016 ISBN:9784263457917

ｍore...

Lectures and oral presentations (6)：

Porphyromonas gingivalis ジンジパインによるphospholipase Cの活性化と歯周組織の炎症との関連性
(第65回歯科基礎医学会学術大会 2023)
歯周病菌 Porphyromonas gingivalis のもつタンパク質分解酵素ジンジパインの病原性
(第66回春季日本歯周病学会学術大会 2023)
チミジル酸合成酵素ThyXの過剰発現はBCGの増殖を促進する
(第69回日本細菌学会中国・四国支部総会 2016)
PI3K/Akt経路に対するP. gingivalis ジンジパインの役割
(第58回歯科基礎医学会学術集会・総会 2016)
Porphyromonas gingivalis ECFシグマ因子変異株における菌体表層性状の解析
(第58回歯科基礎医学会学術集会・総会 2016)

ｍore...

Professional career (1)：

博士(歯学) (長崎大学)

Work history (3)：

2021/04 - 現在岡山大学学術研究院医歯薬学域口腔微生物学分野教授
2009/07 - 2021/03 岡山大学大学院医歯薬学総合研究科口腔微生物学分野教授
2003/04 - 2007/01 長崎大学大学院医歯薬学総合研究科口腔微生物学分野助教授

※ Researcher’s information displayed in J-GLOBAL is based on the information registered in researchmap. For details, see here.

Return to Previous Page