Research field (7)：
Respiratory medicine
, Cardiology
, Pathobiochemistry
, Medical biochemistry
, Pharmacology
, Cell biology
, Molecular biology
Research keywords (6)：
Gas Pharmacology
, Glycosylation
, Signal transduction
, Posttranslational modifications
, S-nitrosylation
, Nitric Oxide
Research theme for competitive and other funds (2)：
一酸化窒素によるシグナル伝達制御系の解明
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Papers (85)：
Hiroko Izumi-Nakaseko, Koki Chiba, Ai Goto, Ryuichi Kambayashi, Akio Matsumoto, Yoshinori Takei, Shinichi Kawai, Atsushi Sugiyama. Electropharmacological Characterization of Licorice Using the Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes Sheets and the Chronic Atrioventricular Block Dogs. Cardiovascular toxicology. 2023. 23. 5-6. 207-217
Hiroko Izumi-Nakaseko, Kengo Sakamoto, Ai Goto, Ryuichi Kambayashi, Akio Matsumoto, Yoshinori Takei, Akira Takahara, Atsushi Sugiyama. Characterization of pathological remodeling in the chronic atrioventricular block cynomolgus monkey heart. Frontiers in pharmacology. 2023. 14. 1055031-1055031
Ryuichi Kambayashi, Hiroko Izumi-Nakaseko, Ai Goto, Yoshinori Takei, Akio Matsumoto, Ulrike Lorch, Jörg Täubel, Atsushi Sugiyama. Both osmolality-dependent and independent mechanisms are associated with acute hyperglycemia-induced cardiovascular adverse reactions: Analysis of the mutual interactions leading to cardiovascular phenotypes in dogs. The Journal of toxicological sciences. 2023. 48. 3. 169-178
Ryuichi Kambayashi, Ai Goto, Hiroko Izumi-Nakaseko, Ichiro Oikawa, Naoki Ikeda, Kazuki Matsuda, Yoshinori Takei, Akio Matsumoto, Yuji Kumagai, Atsushi Sugiyama. Appraisal of ICH E14/S7B Q&As adopted in February 2022 using thorough QT/QTc study data for α4-integrin antagonist carotegrast methyl in Japanese healthy subjects. Journal of pharmacological sciences. 2022. 150. 3. 191-199
Ai Goto, Kengo Sakamoto, Ryuichi Kambayashi, Hiroko Izumi-Nakaseko, Shinichi Kawai, Yoshinori Takei, Akio Matsumoto, Yasunari Kanda, Atsushi Sugiyama. Validation of Risk-Stratification Method for the Chronic Atrioventricular Block Cynomolgus Monkey Model and Its Mechanistic Interpretation Using 6 Drugs With Pharmacologically Distinct Profile. Toxicological sciences : an official journal of the Society of Toxicology. 2022. 190. 1. 99-109
Goto A†, Kambayashi R†, Hagiwara-Nagasawa M†, Izumi-Nakaseko H†, Takei Y†, Kawai S†, Matsumoto A†, Lurie K, Sugiyama A*†. Impact of head-up tilt on expiratory negative airway pressure ventilation-induced cardiovascular hemodynamics in the halothane-anesthetized intact microminipigs. Heart and vessels. 2022. 37. 10. in press-1815
Kambayashi R†, Goto A†, Izumi-Nakaseko H†, Matsumoto A†, Sugiyama A*†. Measurement of early and late repolarization periods in addition to QT interval to help predict the torsadogenic risk of donepezil based on reverse translational animal research on its proarrhythmic potential. Circulation Reports. 2021. 3. 9. 555-556
Hagiwara-Nagasawa M†, Kambayashi R†, Goto A†, Chiba K†, Wada T†, Nunoi Y†, Izumi-Nakaseko H†, Takei Y†, Matsumoto A†, Lurie KG, et al. Effects of mechanical ventilation with expiratory negative airway pressure on porcine pulmonary and systemic circulation: mechano-physiology and potential application. The Journal of Physiological Sciences. 2021. 71. 1. in press-17
Goto A†, Sakamoto K, Hagiwara-Nagasawa M†, Kambayashi R†, Chiba K†, Nunoi Y†, Izumi-Nakaseko H†, Takei Y†, Matsumoto A†, Sugiyama A*†. In vivo analysis of the effects of intravenously as well as orally administered moxifloxacin on the pharmacokinetic and electrocardiographic variables along with its torsadogenic action in the chronic atrioventricular block cynomolgus monkeys. Journal of Pharmacological Sciences. 2020. 143. 4. 272-280
2009/04 - 2018/12 Chiba University Graduate School of Medicine
2006/07 - 2009/03 Osaka University Research Institute for Microbial Diseases
Awards (2)：
2004 - Young Investigator Award (1st place)
2004 - Young Investigator Award (1st place)
Association Membership(s) (5)：
日本NO学会
, Japanese College of Cardiology
, The Japanese Circulation Society
, THE JAPANESE SOCIETY OF INTERNAL MEDICINE
, THE JAPANESE PHARMACOLOGICAL SOCIETY
