Research theme for competitive and other funds (22)：
2021 - 2024 内因性AGEによる組織リモデリング増悪化機構の解明と新規標的治療法の創成
2021 - 2024 炎症抑制性DAMPsの新規同定と炎症性疾患における病態生理学的意義の解明
2018 - 2021 Study of the pathophysiological significance of endogenous AGE as an exacerbating factor for tissue remodeling, and the development of novel targeted therapy
2015 - 2018 Mechanism for microthrombus formation on NETosis and development of therapy for ARDS.
2015 - 2018 Roles of AGEs as exacerbation factor in pathogenesis of tissue remodeling and the development of novel targeted therapy
2015 - 2017 Elucidating the molecular bases and pathophysiological significances of the extracellular inflammasome which drives chronic inflammation
2012 - 2015 Pathophysiological role of AGEs as exacerbation factor in tissue remodeling and molecular targeted therapy
2011 - 2013 The development of broad-spectrum antitumor agents with anti-HMGB1 antibody and clarification of its action mechanism
2009 - 2011 Pathogenesis of tissue remodeling caused by endogenous AGE and advanced targeting therapy
2005 - 2009 Characterization of cell-free protein synthesis system and theapplication for the synthesis of cell membrane protein
2007 - 2008 Structure-activity relationship of intercecullar signaling factor CCN family proteins and their application to drug deve lopment
2004 - 2005 Study on regulation of tissue remodeling by histidine rich plasma factors
2003 - 2004 Inducible histamine protects mice from P.acnes-primed and LPS-induced hepatitis through H2-receptor stimulation
2003 - 2004 Proteomics analysis of plasma protein complex regulating leukocyte interaction.
2000 - 2002 Localigation oi P.acnes in sarcoid granumoma and identification of a liability antigen in P.acnes cell-wall component
1999 - 2000 DNA分解能力を有する触媒抗体の開発と応用
1995 - 1996 Development of immuno PCR method and its biomedical application
1995 - 1996 A study on proteoglycans which have a protective action against neuronal death
1995 - 1995 分子識別能力を持つ抗体類似高分子の開発とイムノアッセイ系への応用
1993 - 1993 温度感受性ポリマーを利用した生体内微量物質精製法の開発応用に関する研究
1992 - 1993 A study on the cell death of primary cultured rat's cortical neurons induced by exicitatory amino acids and protective strategies against it.
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Papers (202)：
Masahiro Watanabe, Takao Toyomura, Hidenori Wake, Takashi Nishinaka, Omer Faruk Hatipoglu, Hideo Takahashi, Masahiro Nishibori, Shuji Mori. Cationic ribosomal proteins can inhibit pro-inflammatory action stimulated by LPS+HMGB1 and are hindered by advanced glycation end products. Biotechnology and applied biochemistry. 2023
Takashi Nishinaka, Omer Faruk Hatipoglu, Hidenori Wake, Masahiro Watanabe, Takao Toyomura, Shuji Mori, Masahiro Nishibori, Hideo Takahashi. Different modulation of STING/TBK1/IRF3 signaling by advanced glycation end products. Archives of biochemistry and biophysics. 2023. 750. 109808-109808
Handong Qiao, Yuta Morioka, Dengli Wang, Keyue Liu, Shangze Gao, Hidenori Wake, Daiki Ousaka, Kiyoshi Teshigawara, Shuji Mori, Masahiro Nishibori. Protective effects of an anti-4-HNE monoclonal antibody against liver injury and lethality of endotoxemia in mice. European Journal of Pharmacology. 2023. 950. 175702-175702
