Kokubo Tetsuro

コクボテツロウ | Kokubo Tetsuro

Affiliation and department：
Homepage URL (1)： http://www.tsurumi.yokohama-cu.ac.jp/mcbl/index2.html

Research field (1)： Molecular biology

Research keywords (13)： RNA binding ptotein , 出芽酵母 , 転写制御 , TAF , TFIID , 基本転写因子 , budding yeast , transcriptional regulation , MRI , imaging , TAF , TFIID , general transcription factor

Research theme for competitive and other funds (33)：

2018 - 2021 Functional analysis of liquid droplet formed by coupling of specific RNA binding proteins and a basal transcription machinery
2015 - 2018 Mechanism of how core transcription factors are involved in regulating transcription and post-transcriptional mRNA fate
2013 - 2015 基本転写因子TFIIDを介した転写調節機構の解明
2012 - 2015 Mechanism of how core transcription factors affect the fate of mRNA
2011 - 2014 Mechanisms of core promoter recognition by general transcription factor TFIID

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Papers (71)：

Shinji Miyasaka, Ryota Kitada, Tetsuro Kokubo. Taf1 N-terminal domain 2 (TAND2) of TFIID promotes formation of stable and mobile unstable TBP-TATA complexes. Gene. 2023. 889. 147800-147800
Ryo Iwami, Naoki Takai, Minenosuke Matsutani, Yuh Shiwa, Haruki Kokubo, Koji Kasahara, Tetsuro Kokubo. TFIID dependency of steady-state mRNA transcription altered epigenetically by simultaneous functional loss of Taf1 and Spt3 is Hsp104-dependent. PLoS ONE. 2023. 18. 2. e0281233
Ryo Iwami, Naoki Takai, Tetsuro Kokubo. The function of Spt3, a subunit of the SAGA complex, in <i>PGK1</i> transcription is restored only partially when reintroduced by plasmid into <i>taf1 spt3</i> double mutant yeast strains. Genes & Genetic Systems. 2020. 95. 3. 151-163
Koji Kasahara, Risa Nakayama, Yuh Shiwa, Yu Kanesaki, Taichiro Ishige, Hirofumi Yoshikawa, Tetsuro Kokubo. Fpr1, a primary target of rapamycin, functions as a transcription factor for ribosomal protein genes cooperatively with Hmo1 in Saccharomyces cerevisiae. PLOS Genetics. 2020. 16. 6. e1008865-e1008865
Yong Wei, Diana Resetca, Zhe Li, Isak Johansson-Åkhe, Alexandra Ahlner, Sara Helander, Amelie Wallenhammar, Vivian Morad, Brian Raught, Björn Wallner, et al. Multiple direct interactions of TBP with the MYC oncoprotein. Nature Structural & Molecular Biology. 2019. 26. 11. 1035-1043

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MISC (18)：

中村美春, 島村直希, 竹内建樹, 中林幸佳, 志波優, 松谷峰之介, 古久保哲朗, 知花博治, 笠原浩司. Regulatory mechanism for transcription of ribosomal protein genes in Candida glabrata. 日本分子生物学会年会プログラム・要旨集(Web). 2023. 46th
笠原浩司, 中山理紗, 志波優, 兼崎友, 石毛太一郎, 吉川博文, 古久保哲朗. 出芽酵母のFK506/ラパマイシン結合タンパク質Fpr1は,リボソームタンパク質遺伝子の転写因子として働く. 日本分子生物学会年会プログラム・要旨集(Web). 2018. 41st
Yoko Yoshida, Xinping Fan, Yoshifumi Ohyama, Tetsuro Kokubo, Masanori Matsumoto, Hideo Yagi, Hiroko Shirotani-Ikejima, Toshiyuki Miyata, Yoshihiro Fujimura. Atypical Hemolytic Uremic Syndrome In Japan Characterized By The Inhibitory Antibody-Based Hemolytic Assay and The Gene Analysis. BLOOD. 2013. 122. 21
吉田瑶子, 範新萍, 本田繁則, 芦田明, 服部元史, 松本雅則, 大山良文, 古久保哲朗, 南学正臣, 宮田敏行, et al. 本邦の非典型溶血性尿毒症症候群(aHUS)の患者登録とその表現型-遺伝子型解析. 日本小児腎臓病学会雑誌. 2013. 26. 1Suppl. 143-143
奇世媛, Tapas K Mal、Le Zheng, 伊倉光彦, 古久保哲朗. FRET(蛍光共鳴エネルギー移動)分光法 ~タンパク質間相互作用の解析~. 実験医学別冊:生命科学のための機器分析実験ハンドブック. 2007. 35-40

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Books (3)：

Mechanisms of Transcriptional Activation and Repression
Springer Science + Business Media LLC 2013
Transcription Initiation in Eukaryote
Springer Science + Business Media 2013
Transcription in Eukaryote
Springer Science + Business Media 2013

Lectures and oral presentations (13)：

出芽酵母においてTAF1のN末端領域欠失変異はRAMシグナル経路の各種変異と合成致死性を示す
(第32回日本分子生物学会年会 2009)
Deletion of the N-terminal domain of TAF1 (taf1-ΔTAND) exhibits synthetic lethality with mutations of the RAM signaling network in budding yeast
(2009)
リボソームタンパク質遺伝子のプロモーターにおけるHMO1の分子機能
(内藤コンファレンス/Nuclear Dynamics and RNA [I] 2008)
TFIIDサブユニットのゲノムワイドなプロモーター結合解析
(第31回日本分子生物学会年会・第81回日本生化学会大会合同大会 2008)
出芽酵母BEM4に見出された転写因子としての新たな機能
(第31回日本分子生物学会年会・第81回日本生化学会大会合同大会 2008)

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Education (3)：

1985 - 1990 The University of Tokyo
- 1985 The University of Tokyo
- 1985 The University of Tokyo Faculty of Agriculture

Professional career (1)：

農学博士 (東京大学)

Work history (1)：

Yokohama City University International College of Arts and Sciences Medical Life Science Graduate School of Medical Life Science Department of Medical Life Science Professor

Awards (1)：

2000 - NAIST学術賞

Association Membership(s) (3)：

日本分子生物学会 , 日本農芸化学会 , 日本遺伝学会

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