Rchr

J-GLOBAL ID：200901025937115351 Update date: Jan. 31, 2024

Takata Takashi

タカタタカシ | Takata Takashi

Affiliation and department：
Job title：学長

Research field (1)： Oral medicine

Research keywords (10)： periodontal tissue , Oral cancer , bone resorption , odontogenic tumors , periodontitis , Molecular pathology , cytokine , diagnosis , tissue regeneration|periodontitis , Tumor suppressor genes|salivary gland tumors

Research theme for competitive and other funds (45)：

2016 - 2019 Determination of anti-osteoclastgenesis sites of lactoferrin and development of peptide therapeutics for bone destructive diseases
2014 - 2017 Large-scale collaborative research on actual condition of odontogenic tumor in Asia
2014 - 2016 Galectin-3 inhibition prevents preterm birth induced by dental infection of Porphyromonas gingivalis.
2013 - 2016 Pathologic and molecular analysis of factors related to the biological behavior of salivary gland tumors
2013 - 2016 Study on pathological progression mechanisms of non-alcoholic steatohepatitis caused by odontogenic infection of periodontal pathogen

2013 - 2016 Effect of F-spondin on the inhibition of alveolar bone resorption

2013 - 2016 The effects of liposomal LF on growth, invasion and bone destruction of oral squamous cell carcinoma (OSCC)

2012 - 2014 Development of novel therapeutic approach of rheumatoid arthritis with liposomalized lactoferrin

2010 - 2012 Strategic Survey of Trends Toward Oral Pathology Standardization and Oral Pathology Board Certification in Asia for the New Century

2009 - 2012 Elucidation of invasive andmetastatic mechanism in oral cancer for application to molecular based diagnosisand gene therapy

2010 - 2011 The investigation on the function of c ementblast marker gene, f-spondin

2009 - 2011 Exploratory study on the development of novel therapy targeting.-glutamyl transpeptidase

2008 - 2010 Histological and molecular biological study for standardization of pathological diagnosis of salivary gland tumors

2007 - 2008 口腔扁平上皮癌の浸潤に関わる新規因子の機能および診断への応用の可能性

2005 - 2007 Development of a novel therapeutic agent of bone using synthetic peptide of ameloblastin

2005 - 2006 PC-1を標的としたセメント質形成機構の解明と歯周再生療法開発に関する萌芽研究

2003 - 2005 Study on alteration of expression of genes and proteins related to development, progression and characteristic morphogenesis of salivary gland tumors

2003 - 2005 Periodontal tissue regeneration by transplantation of own bone marrow mesenchymal stem cells

2004 - 2004 口腔粘膜癌とその境界病変の病理組織学的診断基準のグローバル化策定

2003 - 2004 多形性腺腫細胞株の樹立と同細胞株を用いた上皮間葉形質転換に関する検討

2002 - 2004 Identification creation of bioactive sites of enamel proteins for developing a new therapy of periodontal tissue regeneration.

2002 - 2003 Study of roles of epithelial cell rests of Malassez in periodontal regeneration

2001 - 2002 口腔扁平上皮癌におけるSKP2の発現およびp27タンパク分解との関連

2001 - 2002 The Effects of Alteration of Expression of Cell Adhesion Molecules on Various Morphogenesis amd Biological Behaviors in Salivary Gland Tumors

2000 - 2001 Experimental pathological study on roles of chemokines in LPS-induced periodontal tissue destruction - Basic analysis on remedical effects of specific antibody against chemokine -

1999 - 2001 Establishment of cementblast cell lines and periodontal ligament cell lines

1998 - 2000 Development of dental implant with support of periodontal ligament

1999 - 1999 アジアの口腔病変の比較検討と今後の展開(日本口腔病理学会主催国際シンポジウム)

1999 - 1999 口腔腫瘍発生状況の地域・人種差に関する国際共同研究のための予備調査

1998 - 1999 Experimental pathological study on roles of LPS-binding receptor CD14 in LPS-induced periodontal tissue destruction

1998 - 1999 Analysis of Cell Cycle Regulators and Extracellular Matrices Associated with Cell Proliferation in Salivary Gland Tumors

1998 - 1999 Comprehensive study of root surface treatment and regeneration in periodontal disease

1997 - 1999 Study of Periodontal Tissue Reconstruction using Various Growth Factors

1996 - 1997 Experimental study on periodontal tissue regeneration by transplantation of cultured periodontal ligament cells

1996 - 1997 Synthetic Studies of Age Changes on Priodontium

1995 - 1997 Molecular pathological study on development, progression and prognosis of oral squamous cell carcinoma

1996 - 1996 歯周組織破壊におけるサイトカインの役割りに関する実験病理学的研究

1993 - 1994 Basic studies for the development of a new dental implant system with the support of periodontal ligament

1993 - 1994 Morphological and quantifical analysis of proliferative activity of tumor cells in salivary gland tumors

1993 - 1993 各種インプラント材料の歯周靭帯形成能

1991 - 1992 Analvsis of the cell components of various salivary gland tumors for establishing their diagnostic criteria and subclassification

1989 - 1990 歯周疾患における細胞性免疫応答関連細胞に関する研究

1988 - 1988 唾液腺粘表皮腫の組織発生に関する研究

1986 - 1987 辺縁性歯周炎の発生におけるプロスタグランデインの作用機序解明に関する病理学的研究

1985 - 1986 Studies on Myoepithelial Cell Differentiation in Salivary Gland Tumors

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Papers (446)：

Shinnichi Sakamoto, Atsuhiro Nagasaki, Madhu Shrestha, Tomoaki Shintani, Atsushi Watanabe, Hisako Furusho, Kazuaki Chayama, Takashi Takata, Mutsumi Miyauchi. Porphyromonas gingivalis-odontogenic infection is the potential risk for progression of nonalcoholic steatohepatitis-related neoplastic nodule formation. Scientific reports. 2023. 13. 1. 9350-9350
Nurina Febriyanti Ayuningtyas, Chanbora Chea, Toshinori Ando, Karina Erda Saninggar, Keiji Tanimoto, Toshihiro Inubushi, Nako Maishi, Kyoko Hida, Masanobu Shindoh, Mutsumi Miyauchi, et al. Bovine Lactoferrin Suppresses Tumor Angiogenesis through NF-κB Pathway Inhibition by Binding to TRAF6. Pharmaceutics. 2023. 15. 1. 165-165
Shunryou Yanagisawa, Karin Nagasaki, Chanbora Chea, Toshinori Ando, Nurina Febriyanti Ayuningtyas, Toshihiro Inubushi, Atsushi Ishikado, Hiromichi Imanaka, Eiji Sugiyama, Ichiro Takahashi, et al. Oral administration of bovine lactoferrin suppresses the progression of rheumatoid arthritis in an SKG mouse model. PLOS ONE. 2022. 17. 2. e0263254-e0263254
Ryo Kunimatsu, Aya Kimura, Shuzo Sakata, Yuji Tsuka, Yuki Yoshimi, Takaharu Abe, Isamu Kado, Yuka Yashima, Jin Izumino, Ayaka Nakatani, et al. Effects of baicalin on the proliferation and expression of OPG and RANKL in human cementoblast-lineage cells. Journal of dental sciences. 2022. 17. 1. 162-169
Atsuhiro Nagasaki, Shinnichi Sakamoto, Toshiki Arai, Minami Kato, Eri Ishida, Hisako Furusho, Makiko Fujii, Takashi Takata, Mutsumi Miyauchi. Elimination of Porphyromonas gingivalis inhibits liver fibrosis and inflammation in NASH. Journal of Clinical Periodontology. 2021. 48. 10. 1367-1378

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MISC (90)：

Yuko Teraoka, Hiroshi Miyoshi, Haruhisa Konishi, Satoshi Urabe, Mutsumi Miyauchi, Takashi Takata, Yoshiki Kudo. Inflammation on the Amniotic Membrane Induces Preterm Delivery in Mice with Chronic Dental Porphyromonas gingivalis Infection. REPRODUCTIVE SCIENCES. 2017. 24. 238A-238A
Haruhisa Konishi, Hiroshi Miyoshi, Yuko Teraoka, Satoshi Urabe, Hisako Furusho, Mutsumi Miyauchi, Takashi Takata, Yoshiki Kudo. Progesterone Prevents Preterm Birth by Suppressing the Enhancement of Uterine Contractility in Mice with Chronic Dental Porphyromonas gingivalis Infection. REPRODUCTIVE SCIENCES. 2017. 24. 175A-175A
高田隆, 仙波伊知郎, 前田初彦, 武田泰典, 熊本裕行, 久山佳代, 豊澤悟, 長塚仁, 宮内睦美, 小川郁子. アジアにおける歯原性腫瘍の実態に関する大規模共同調査研究. 日本病理学会会誌. 2017. 106. 1. 423-423
高田隆, 宮内睦美, 古庄寿子. 講演慢性歯性感染症と全身の健康 : P.gingivalisの歯性感染は非アルコール性脂肪性肝炎のリスクファクターである (特集病気の芽を摘む! 検診でできる疾患予防の最前線 : 歯周病 NASH 胃がん). アニムス = Animus : 最新医療情報誌. 2017. 22. 4. 11-18
川瀬真紀, 三村純代, 木原琢也, 首藤崇裕, 田地豪, 二川浩樹, 高田隆. チーム医療教育へのヒント:課題発見・解決型,チーム型,デザイン・シンキングによるバイオデンタル教育. 日本歯科医学教育学会総会・学術大会プログラム・抄録集. 2016. 35th. 85-85

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Books (65)：

口腔科学 = Stomatology
朝倉書店 2019 ISBN:9784254350029
ザ・ペリオドントロジー = The periodontology
永末書店 2019 ISBN:9784816013584
唾液腺/口腔・歯原性腫瘍
中山書店 2019 ISBN:9784521742724
病理組織の見方と鑑別診断第6版消化器系
医歯薬出版 2018 ISBN:9784263731857
口腔病理アトラス
文光堂 2018 ISBN:9784830670046

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Lectures and oral presentations (20)：

歯周組織構成細胞の増殖分化に対するエナメルタンパクの影響
(第48回日本顕微鏡学会 2003)
「歯周組織再生」の考え方
(第21回日本歯周外科学会 2003)
口腔癌の診断および予後判定への細胞周期調節因子異常解析の応用
(第48回日本口腔外科学会総会 2003)
唾液腺腫瘍の病理ー現行WHO国際分類に新しく加えられた腫瘍型の特徴を中心にー
(第50回日本口腔科学会中国四国地方部会 2002)
Biological functions of enamel matrix proteins in periodontal tissue regeneration.
(56th Korean Academy for Oral Maxillofacial Pathology 2001)

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Education (2)：

1978 - 1982 Hiroshima University Graduate School, Division of Dental Research
1972 - 1978 Hiroshima University Faculty of Dentistry

Professional career (1)：

Ph.D. (Hiroshima University)

Work history (8)：

2022/04 - 現在 Shunan University Chairman, President
2019/04 - Tokuyama University President
2015/04/01 - Hiroshima University Executive and Vice President(Industry-Academia-Government Collaboration, Community Relations, Public Relations and Academic Information)
2008/04/01 - 2010/03/31 Hiroshima University Faculty of Dentistry Dean
2001/04/01 - Hiroshima University Professor.

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Committee career (18)：

2011/10 - 2017/09 日本学術会議日本学術会議連携会員
2014/09 - 2017/03 日本歯科医学会総会準備委員会委員
2014/05 - 2016/05 厚生労働省歯科医師試験委員
2015/04 - 2016/03 朝日大学非常勤講師
2015/04 - 2016/03 東京歯科大学非常勤講師

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Awards (6)：

2018/10 - Kingdom of Cambodia) Royal Order of Sahametrei (An order for friendship from Kingdom of Cambodia)
2018/07 - International Association for Dental Research (IADR) Distinguished Scientist Award
2017/02/20 - 日本歯科医学会会長平成28年度日本歯科医学会会長賞
2010/11/01 - 日本歯周病学会第96回米国歯周病学会・日本歯周病学会最優秀ポスター賞
2003/09 - 歯科基礎医学会歯科基礎医学会ライオン学術賞 p27を標的とした口腔癌の遺伝子診断および遺伝子治療法の開発を目指した研究

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Association Membership(s) (13)：

硬組織生物学会 , 歯科基礎医学会 , 日本病理学会 , 日本法歯科医学会 , 日本歯科教育学会 , 日本歯科医学会 , 日本歯周病学会 , 日本唾液腺学会 , 日本口腔病理学会 , 日本口腔外科学会 , 広島大学歯学会 , International Association for Dental Research , International Association of Oral Pathologist

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