Rchr
J-GLOBAL ID：200901026250069160   Update date: Feb. 01, 2024

Tanaka Masakazu

タナカ マサカズ | Tanaka Masakazu
Affiliation and department：
Kagoshima University Joint Research Center for Human Retrovirus Infection Division of Neuroimmunology

About Kagoshima University Joint Research Center for Human Retrovirus Infection Division of Neuroimmunology


Job title： Associate Professor
Research field  (4)： Virology ,  Immunology ,  Pathobiochemistry ,  Laboratory animal science
Research theme for competitive and other funds  (6)：
  • 2019 - 2022 Development of a new treatment for HAM/TSP targeting HTLV-1-infected cells
  • 2014 - 2017 Elucidation of the gene variation accumulation mechanism in the tumor developmental process using HTLV -1 humanized mouse
  • 2012 - 2015 Establishment of HTLV-1 infection model via dendritic cells and the use to screening of medicines.
  • 2009 - 2011 Study of mechanism for the development of ATL and HAM by using HTLV-1 infected humanized mouse model
  • 2004 - 2006 HTLV-1感染による多段階発癌機構の検討
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Papers (40)：
  • EIJI MATSUURA, Nozuma S, Dozono M, Daisuke Kodama, Masakazu Tanaka, Kubota R, Takashima H. Iliopsoas Muscle Weakness as a Key Diagnostic Marker in HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP). Pathogens (Basel, Switzerland). 2023
  • Nozuma S, Matsuura E, Masakazu Tanaka, Daisuke Kodama, Matsuzaki T, Yoshimura A, Sakiyama Y, Nakahata S, Morishita K, Yoshimi Enose-Akahata, et al. Identification and tracking of HTLV-1-infected T cell clones in virus-associated neurologic disease. JCI insight. 2023
  • Masakazu Tanaka, Masatoshi Mushiake, Jun Takahashi, Yuka Sasaki, Sachiko Yamashita, Chieri Ida, Mitsuko Masutani, Masanao Miwa. PARP Inhibitor Decreases Akt Phosphorylation and Induces Centrosome Amplification and Chromosomal Aneuploidy in CHO-K1 Cells. International journal of molecular sciences. 2022. 23. 7
  • Daisuke Kodama, Masakazu Tanaka, Toshio Matsuzaki, Satoshi Nozuma, Eiji Matsuura, Hiroshi Takashima, Shuji Izumo, Ryuji Kubota. Anti-Human T-Cell Leukemia Virus Type 1 (HTLV-1) Antibody Assays in Cerebrospinal Fluid for the Diagnosis of HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis. Journal of clinical microbiology. 2021. 59. 5
  • Daisuke Kodama, Masakazu Tanaka, Toshio Matsuzaki, Kimiko Izumo, Nobuaki Nakano, Eiji Matsuura, Mineki Saito, Masahiro Nagai, Masahisa Horiuchi, Atae Utsunomiya, et al. Inhibition of ABL1 tyrosine kinase reduces HTLV-1 proviral loads in peripheral blood mononuclear cells from patients with HTLV-1-associated myelopathy/tropical spastic paraparesis. PLoS neglected tropical diseases. 2020. 14. 7. e0008361-21
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MISC (103)：
  • 兒玉大介, 田中正和, 松崎敏男, 松崎敏男, 野妻智嗣, 松浦英治, 高嶋博, 出雲周二, 久保田龍二. HAM診断に適した髄液中抗HTLV-1抗体検査法. 日本神経学会学術大会プログラム・抄録集. 2022. 63rd
  • 兒玉大介, 田中正和, 松崎敏男, 松崎敏男, 野妻智嗣, 松浦英治, 高嶋博, 出雲周二, 久保田龍二. 抗HTLV-1抗体髄液検査はCLIA法が適している. Neuroinfection (Web). 2022. 27. 2
  • 田中正和, 有島志保, 三輪正直, 野妻智嗣, 松浦英治, 高嶋博, 出雲周二, 久保田龍二. HAMにおけるPARP活性化を介した神経細胞死の検討. Neuroinfection (Web). 2022. 27. 2
  • 児玉大介, 田中正和, 松崎敏男, 松崎敏男, 野妻智嗣, 松浦英治, 高嶋博, 出雲周二, 久保田龍二. 髄液中抗HTLV-1抗体検査とHAM診断. 日本HTLV-1学会学術集会. 2021. 7th
  • Masanao Miwa, Shuji Hanai, Sachiko Yamashita, Masakazu Tanaka, Kazuhiko Uchida. Drosophila melanogaster as a model for understanding polyADP-ribosylation. Frontiers in bioscience (Landmark edition). 2020. 25. 1. 118-133
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Patents (1)：
Lectures and oral presentations  (28)：
  • HTLV-1感染ヒト化マウスモデルにおける感染T細胞の動態
    (第1回HTLV-1研究会・合同班会議 2008)
  • マウスin vivo感染系におけるHTLV-1の感染細胞特異性
    (第1回HTLV-1研究会・合同班会議 2008)
  • HTLV-1感染SCID-huマウスにおけるCD4+CD25+ヒトTリンパ球増大
    (第67回日本癌学会学術総会 2008)
  • DNA損傷がない条件下において、ポリADP-リボシル化阻害は中心体増幅を引き起こす
    (第67回日本癌学会学術総会 2008)
  • HTLV-1感染におけるラクトフェリンの免疫活性効果
    (第56回日本ウイルス学会学術集会 2008)
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Association Membership(s) (3)：
日本ラクトフェリン学会 ,  日本ウイルス学会 ,  日本HTLV-1学会
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