Shibasaki Hiromi

シバサキヒロミ | Shibasaki Hiromi

Affiliation and department：
Job title： Lecturer

Research field (3)： Metabolism and endocrinology , Pharmacology , Clinical pharmacy

Research keywords (6)：分析化学 , 薬物動態学 , 臨床薬学 , Analytical Chemistry , Biological Chemistry , Clinical Pharmacy

Research theme for competitive and other funds (19)：

2012 - 2015 The relationship between 11beta-hydroxysteroid dehydrogenase 2 enzyme activity and blood pressure in patients with renal disease
2004 - 2006 Evaluation of in vivo enzymatic activity of cortisol metabolism associated with hypertension
2000 - 2002 Evaluation of in vivo enzymatic activity of cortisol metabolism associated with hypertension
2000 - 2002 Enantioselective synthesis of glucocorticoids by the indan synthon method and its application to the preparation of the multi-labeled glucocorticoids with stable isotopes
1997 - 1999 Evaluation of in vivo enzymatic activity of cortisol metabolism associated with hypertension

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Papers (88)：

Ryohei Hirano, Akitomo Yokokawa, Tomomi Furihata, Hiromi Shibasaki. Plasma 6β-hydroxycortisol to cortisol ratio as a less-invasive cytochrome P450 3A phenotyping method. British journal of clinical pharmacology. 2023
Aya Yamagata, Rena Adachi, Akitomo Yokokawa, Tomomi Furihata, Hiromi Shibasaki. Quantification of fluticasone propionate in human plasma by LC-MS/MS and its application in the pharmacokinetic study of nasal spray at clinical doses. Drug metabolism and pharmacokinetics. 2023. 54. 100541-100541
島崎隼人, 高野大輝, 尾川慎悟, 深江桃花, 秋山遥香, 五十嵐俊二, 降幡知巳, 柴崎浩美, 横川彰朋. LC-MS/MSを用いた血中メラトニンとカフェイン,パラキサンチン濃度の定量法の開発. JSBMS Letters. 2023. 48. Suppl. 62-62
佐藤修輔, 長谷川弘, 横川彰朋, 山本安則, 三宅映己, 日浅揚一, 降幡知巳, 柴崎浩美. 安定同位体トレーサー法による体内動態解析を目指したGC-MSによるパルミチン酸定量法の確立. JSBMS Letters. 2023. 48. Suppl. 74-74
Shimazaki Hayato, Ogawa Shingo, Takano Hiroki, Ohki Seiya, Fukae Momoka, Furihata Tomomi, Shibasaki Hiromi, Yokokawa Akitomo. Comparative study of stable isotope-labeled internal standard substances for the LC-MS/MS determination of the urinary excretion of melatonin(タイトル和訳中). Medical Mass Spectrometry. 2023. 7. 1. 53-59

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MISC (86)：

猪貝結実, 高田真希, 九原楓香, 横川彰朋, 降幡知巳, 柴崎浩美. Simultaneous determination of 6β-hydroxycortisol and cortisol in human nail by LC-MS/MS for evaluation of CYP3A activity. 日本薬学会年会要旨集(Web). 2023. 143rd
柴崎浩美, 横川彰朋, 降幡知巳. The effects of anticoagulants and storage conditions on plasma concentrations of 6β-hydroxycortisol and cortisol as determined by LC-MS/MS. JSBMS Letters. 2021. 46. Supplement
大木聖矢, 國松海佑, 尾川慎悟, 高野大輝, 降幡知巳, 柴崎浩美, 横川彰朋. Development of a LC-MS/MS-based quantification method for urinary endogenous 6-hydroxymelatonin to evaluate melatonin secretion. JSBMS Letters. 2021. 46. Supplement
横川彰朋, 北野彩, 田中大地, 東海, 簗田駿, 清水康平, 平野良平, 古田隆, 降幡知巳, 柴崎浩美. The effect of 11β-HSD2 activity on the prediction of plasma unbound cortisol concentration from saliva concentration. 日本薬学会年会要旨集(CD-ROM). 2020. 140th (Web)
江間義大, 大森悠平, 府川哲之, 小栗卓朗, 横川彰朋, 降幡知巳, 柴崎浩美. Measurement of unbound docetaxel concentration in human plasma by HPLC-UV. 日本薬学会年会要旨集(CD-ROM). 2020. 140th (Web)

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Patents (2)：

ヒトにおけるCYP3A酵素活性の評価方法(フェノタイプ検査法)
基材上に保持された乾燥血液を用いたヒトのCYP3A酵素活性の評価方法

Books (2)：

テーラーメイド医療 : 薬物治療の個別化
京都廣川書店 2017 ISBN:9784906992966
テーラーメイド医療-薬物治療の個別化
京都廣川書店 2010 ISBN:4901789619

Lectures and oral presentations (23)：

安定同位体標識体を内標準物質とした血漿、全血液、乾燥ろ紙血中の cortisol と 6β-hydroxycortisol の LC-MS/MS による定量
(第12回日本安定同位体・生体ガス医学応用学会大会 2021)
LC-MS/MS による6β-hydroxycortisol およびcortisol の血中濃度測定に抗凝固剤と保存法が及ぼす影響の解明
(第46回日本医用マススペクトル学会年会)
Melatonin 分泌評価のための尿中6-hydroxymelatonin のLC- MS/MS による測定法の確立
(第46回日本医用マススペクトル学会年会)
唾液を用いた血中コルチゾール非結合型濃度の予測に及ぼす11β-HSD2活性の影響
HPLC-UVによるタキサン系抗がん薬ドセタキセルの血中非結合型濃度の定量法の検討
(第140回日本薬学会)

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Professional career (1)：

Ph. D (Tokyo University of Pharmacy and Life Science)

Work history (1)：

2011/04 - 現在 Tokyo University of Pharmacy and Life Sciences Associate Professor

Committee career (1)：

2023/05 - 現在日本安定同位体・生体ガス医学応用学会評議員

Awards (1)：

2012/06 - 日本TDM学会第29回日本TDM学会・学術大会優秀演題賞

Association Membership(s) (12)：

日本安定同位体・生体ガス医学応用学会 , 日本TDM学会 , 日本臨床化学会 , 日本医用マススペクトル学会 , 日本薬物動態学会 , 日本内分泌学会 , International Isotope Society , 日本薬学会 , Japan Society for Therapeutic Drug Monitoring , Japanese Society for the Study of Xenobiotics , The Japan Endocrine Society , The Pharmaceutical Society of Japan

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