HWANG Gi-Wook

フアンギウク | HWANG Gi-Wook

Affiliation and department：
Job title： Professor
Homepage URL (1)： https://nrid.nii.ac.jp/ja/nrid/1000000344680/

Research field (3)： Environmental effects of chemicals , Environmental effects of radiation , Pharmaceuticals - health and biochemistry

Research keywords (4)： Brain Inflammation , 環境汚染物質 , 重金属 , 毒性発現機構

Research theme for competitive and other funds (18)：

2022 - 2025 Mechanisms underlying methylmercury-induced brain damage mediated by lymphotoxin β-receptor
2022 - 2025 メチル水銀の低濃度曝露によるミクログリアの活性化機構とその毒性学的意義の解明
2022 - 2024 Involvement of cadmium as an aggravating factor in ulcerative colitis
2019 - 2022 転写因子TCF3によるメチル水銀毒性軽減機構の解明
2019 - 2022 メチル水銀によるTNF受容体3を介した脳神経細胞死誘導機構

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Papers (108)：

Naoya Yamashita, Marino Uchiyama, Ryota Yamagata, Gi-Wook Hwang. Methylmercury Induces Apoptosis in Mouse C17.2 Neural Stem Cells through the Induction of OSGIN1 Expression by NRF2. International Journal of Molecular Sciences. 2024. 25. 7. 3886-3886
Shuhei Hamano, Takuya Noguchi, Yukino Asai, Ryo Ito, Ryuto Komatsu, Tetsu Sato, Aya Inoue, Tomoe Maruyama, Tada-aki Kudo, Yusuke Hirata, et al. Aggregability of the SQSTM1/p62-based aggresome-like induced structures determines the sensitivity to parthanatos. Cell Death Discovery. 2024. 10. 1
Takashi Toyama, Sidi Xu, Yoshitomi Kanemitsu, Takashi Hasegawa, Takuya Noguchi, Jin-Yong Lee, Atsushi Matsuzawa, Akira Naganuma, Gi-Wook Hwang. Methylmercury directly modifies the 105th cysteine residue in oncostatin M to promote binding to tumor necrosis factor receptor 3 and inhibit cell growth. Archives of Toxicology. 2023. 97. 7. 1887-1897
Jin-Yong Lee, Maki Tokumoto, Gi-Wook Hwang, Masahiko Satoh. Effect of cadmium on expression of BIRC family genes in HeLa cells. Fundamental Toxicological Sciences. 2023. 10. 3. 133-136
Hiroshi Hasegawa, Toshiya Tanaka, Mari Kondo, Koji Teramoto, Kei Nakayama, Gi-Wook Hwang. Blood vessel remodeling in the cerebral cortex induced by binge alcohol intake in mice. Toxicological Research. 2023. 39. 1. 169-177

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MISC (19)：

Gi-Wook Hwang. Recent research on the underlying mechanisms of methylmercury toxicity. Journal of Tohoku Medical and Pharmaceutical University. 2020. 67. 15-23
Jin-Yong Lee, Gi-Wook Hwang, Akira Naganuma, Masahiko Satoh. Methylmercury toxic mechanism related to protein degradation and chemokine transcription. Environmental Health and Preventive Medicine. 2020. 25. 1. 30
Gi-Wook Hwang. Toxicity of metals. Lu's basic toxicology: fundamentals, target organs, and risk assessment. CRC press. 2017. 499-523
黄基旭, Ha-Ryong Kim, 永沼章, Kyu-Hyuck Chung. 韓国で発生した加湿器殺菌剤による健康被害. 毒性学ニュース. 2016. 41. 96-102
Ha Ryong Kim, Gi Wook Hwang, Akira Naganuma, Kyu Hyuck Chung. Adverse health effects of humidifier disinfectants in korea: Lung toxicity of polyhexamethylene guanidine phosphate. Journal of Toxicological Sciences. 2016. 41. 6. 711-717

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Patents (1)：

Books (5)：

Lectures and oral presentations (40)：

メチル水銀毒性とミクログリア
(第50回日本毒性学会学術年会、シンポジウム 2023年 2023)
メチル水銀毒性軽減に関わる低分子代謝物の同定とその作用機構
(メタルバイオサイエンス研究会2021、シンポジウム 2021)
A novel strategy to elucidate the mechanism of methylmercury toxicity
(2021 International Symposium of RIPS-CFPS, Invited lecture 2021)
Novel signaling pathway related to methylmercury toxicity
(2020)
Elucidation of novel molecular mechanisms involved in the reduction of methylmercury toxicity by using metabolomic analysis
(2020)

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Professional career (1)：

Work history (8)：

2020/04 - 現在 Tohoku Medical and Pharmaceutical University Faculty of Pharmaceutical Sciences, Laboratory of Environmental and Health Sciences Professor
2018/04 - 2021/03 筑波大学国際連携食料健康科学専攻非常勤講師(兼任)
2015/04 - 2020/03 Tohoku University Graduate School of Pharmaceutical Sciences Associate Professor
2010/04 - 2015/03 Tohoku University Graduate School of Pharmaceutical Sciences Senior Assistant Professor
2014/06 - 2014/09 オタワ大学客員教授

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Committee career (22)：

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Awards (13)：

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Association Membership(s) (5)：

Korean Society of Toxicology , Society of Toxicology , 日本毒性学会 , 日本生化学会 , 日本薬学会

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