Uchida Takayuki

ウチダタカユキ | Uchida Takayuki

Affiliation and department：

Research field (2)： Cell biology , Cell biology

Research keywords (13)： DNA replication , Endoreduplication , Cell Cycle , transcription factor , E2F , Hepatocellular Carcinoma , liver regeneration , cell proliferation , cerebellum , cell differentiation , neural stem cell , neuron , glia

Research theme for competitive and other funds (4)：

2007 - 2009 Control of astrocyte differentiation in EGF-responsive neural stem cells from developing mouse cerebellum
2006 - 2007 Survival of cerebellar GABAergic interneurons
2005 - 2007 Translational Research for axona regeneration by using Stroke model of minature pig
2003 - 2006 Is it possible to turn neuronal precursor cells into neural stem cells?

Papers (14)：

Maria C Cuitiño, Thierry Pécot, Daokun Sun, Raleigh Kladney, Takayuki Okano-Uchida, Neelam Shinde, Resham Saeed, Antonio J Perez-Castro, Amy Webb, Tom Liu, et al. Two Distinct E2F Transcriptional Modules Drive Cell Cycles and Differentiation. Cell reports. 2019. 27. 12. 3547-3560
Takayuki Okano-Uchida, Lindsey N Kent, Madhu M Ouseph, Britney McCarty, Jeffrey J Frank, Raleigh Kladney, Maria C Cuitino, John C Thompson, Vincenzo Coppola, Maki Asano, et al. Endoreduplication of the mouse genome in the absence of ORC1. Genes & development. 2018. 32. 13-14. 978-990
Takayuki Okano-Uchida, Masae Naruse, Takayuki Ikezawa, Koji Shibasaki, Yasuki Ishizaki. Cerebellar neural stem cells differentiate into two distinct types of astrocytes in response to CNTF and BMP2. Neuroscience letters. 2013. 552. 15-20
Na Cai, Masashi Kurachi, Koji Shibasaki, Takayuki Okano-Uchida, Yasuki Ishizaki. CD44-positive cells are candidates for astrocyte precursor cells in developing mouse cerebellum. Cerebellum (London, England). 2012. 11. 1. 181-93
Kingsley Ibhazehiebo, Toshiharu Iwasaki, Takayuki Okano-Uchida, Noriaki Shimokawa, Yasuki Ishizaki, Noriyuki Koibuchi. Suppression of thyroid hormone receptor-mediated transcription and disruption of thyroid hormone-induced cerebellar morphogenesis by the polybrominated biphenyl mixture, BP-6. Neurotoxicology. 2011. 32. 4. 400-9

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MISC (15)：

Y. Ishizaki, N. Cai, T. Okano-Uchida, M. Kurachi, K. Shibasaki. CONTROL OF NEURAL CELL PROLIFERATION AND DIFFERENTIATION IN THE DEVELOPING CEREBELLUM. JOURNAL OF NEUROCHEMISTRY. 2010. 115. 62-62
Masashi Kurachi, Na Cai, Koji Shibasaki, Takayuki Okano-Uchida, Yasuki Ishizaki. Characterization of CD44-positive cells in the developing mouse cerebellum. NEUROSCIENCE RESEARCH. 2010. 68. E131-E131
今井英明, FARIED Ahmad, SANDRA Puentes, 倉知正, 内田孝幸, 石崎泰樹, 三國雅彦, 好本裕平. 脳血管内皮細胞においてシロスタゾールが及ぼすタンパク発現・調節に関する網羅的解析. 脳循環代謝. 2009. 21. 1. 105
Y. Ishizaki, T. Okano-Uchida, K. Sekimoto, S. Saito, T. Iso, M. Kurabayashi. Notch signaling inhibits astrocytic differentiation of neural stem cells in the developing mouse cerebellum. FEBS JOURNAL. 2008. 275. 90-90
プエンテスサンドラ, 今井英明, 内田孝幸, 風間健, 石崎泰樹, 好本裕平. 灰白質と白質におけるグルタミン酸(AMPA)による細胞傷害程度(脆弱性)の違い. 脳循環代謝. 2007. 19. 2. 99

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Lectures and oral presentations (27)：

Mouse endoreduplicating cells replicate DNA in the absence of ORC1
(2018 ASCB/EMBO Annual Meeting 2018)
ORC1-independent DNA replication in mouse endoreduplication cells
(Gordon Research Conference 2017)
Mouse endoreduplication in the absence of ORC1
(Hollings Cancer Center 2017 Spring Research Symposium 2017)
Role of Mouse ORC1 in Mitotic Replication and Endoreplication
(Molecular Biology and Cancer Genetics Program 2014 Retreat 2014)
Notch signaling regulates astrocyte differentiation of the EGF-responsive cells in the postnatal mouse cerebellum
(2008)

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Education (3)：

1992 - 1997 Tokyo Institute of Technology Graduate School of Bioscience and Biotechnology
1990 - 1992 Tokyo Institute of Technology Graduate School of Science and Engineering Bioscience
1986 - 1990 Tokyo Institute of Technology Faculty of Science Department of Chemistry

Professional career (1)：

Doctor(Science) (Tokyo Institute of Technology)

Work history (7)：

2022/04 - 現在 Chubu University Frontier Research Institute
2020/07 - 2022/03 Medical College of Wisconsin Department of Biochemistry Research Scientist II
2017/03 - 2020/07 Medical University of South Carolina, Hollings Cancer Center Department of Biochemistry Staff Scientist II
2014/07 - 2017/02 The Ohio State University Comprehensive Cancer Center Research Associate 2 B/H
2010/03 - 2014/07 The Ohio State University Comprehensive Cancer Center Postdoctoral Researcher

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Association Membership(s) (6)：

The American Society for Cell Biology , 日本神経化学会 , The Society for Neuroscience , 日本神経科学学会 , 日本分子生物学会 , 日本細胞生物学会

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