TAKASHI IWAI

Iwai Takashi | TAKASHI IWAI

Affiliation and department：
Job title： Lecturer/Junior Associate Professor

Research field (3)： Pharmaceuticals - health and biochemistry , Neuroscience - general , Psychiatry

Research keywords (6)： δ opioid , chronic stress , Cognitive function , GABA , Antidepressant , Glucagon-like peptide

Research theme for competitive and other funds (4)：

2020 - 2023 うつ病の認知機能障害に対する治療法の解明:δオピオイド受容体を介した改善機序
2010 - 2012 Prg1, regulated by MATH2, is an important factor for survival of neurons derived from neural stem cells
2010 - 2012 Gene expression analysis in ventral and dorsal hippocampal dentate gyrus after 4 weeks treatment with sertraline
2011 - 2011 うつ病治癒メカニズム解明に向けた神経新生におけるrhotekinの機能解析

Papers (47)：

Takashi Iwai, Rei Mishima, Shigeto Hirayama, Honoka Nakajima, Misa Oyama, Shun Watanabe, Hideaki Fujii, Mitsuo Tanabe. SYK-623, a δ Opioid Receptor Inverse Agonist, Mitigates Chronic Stress-Induced Behavioral Abnormalities and Disrupted Neurogenesis. Journal of Clinical Medicine. 2024. 13. 2. 608-608
Motoki Morita, Shun Watanabe, Natsumi Nomura, Kanako Takano-Matsuzaki, Misa Oyama, Takashi Iwai, Mitsuo Tanabe. Sulfatide-selectin signaling in the spinal cord induces mechanical allodynia. Journal of neurochemistry. 2022
Junpei Takahashi, Yudai Ueta, Daisuke Yamada, Sachie Sasaki-Hamada, Takashi Iwai, Tomomi Akita, Chikamasa Yamashita, Akiyoshi Saitoh, Jun-Ichiro Oka. Intracerebroventricular administration of oxytocin and intranasal administration of the oxytocin derivative improve β-amyloid peptide (25-35)-induced memory impairment in mice. Neuropsychopharmacology reports. 2022
Misa Oyama, Shun Watanabe, Takashi Iwai, Mitsuo Tanabe. Distinct synaptic mechanisms underlying the analgesic effects of GABA transporter subtypes 1 and 3 inhibitors in the spinal dorsal horn. Pain. 2022. 163. 334-349
Sachie Sasaki-Hamada, Ayumu Fujiwara, Show Satoh, Takashi Iwai, Jun-Ichiro Oka. GLP-2 restores impairments in spatial working memory and hippocampal LTD via the MEK/ERK pathway in juvenile-onset diabetes rats. Behavioural brain research. 2021. 406. 113235-113235

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MISC (35)：

丹野真由香, 中村亮介, 高根沢康一, 大城有香, 浦口晋平, 白畑辰弥, 小西成樹, 岩井孝志, 小林義典, 田辺光男, et al. Dynamic weight bearing testを用いたMeHg毒性の評価. 日本薬学会年会要旨集. 2020. 140年会. 28Q-am145S
丹野真由香, 中村亮介, 高根沢康一, 大城有香, 浦口晋平, 白畑辰弥, 小西成樹, 岩井孝志, 小林義典, 田辺光男, et al. Evaluation of MeHg toxicity using dynamic weight bearing test. 日本薬学会年会要旨集(CD-ROM). 2020. 140th
中村亮介, 岩井孝志, 白畑辰弥, 小西成樹, 高根沢康一, 大城有香, 浦口晋平, 田辺光男, 小林義典, 清野正子. Oleanolic acid-3-glucoside, a synthetic oleananetype saponin, ameliorates methylmercury-induced neurotoxicity in vivo. Journal of Toxicological Sciences. 2020. 45. Supplement
中村亮介, 高根沢康一, 曽根有香, 浦口晋平, 白畑辰弥, 岩井孝志, 小林義典, 田辺光男, 清野正子. メチル水銀による神経伝達障害に対するオレアノール酸3-グルコシドの効果. 日本薬学会年会要旨集(CD-ROM). 2019. 139th
宿利美香, 大内彩子, 内藤康仁, 岩井孝志, 渡辺俊, 尾山実砂, 植松智, 審良静男, Jakobsson Per-Johan, 田辺光男, et al. mPGES-1阻害薬のマウス脳梗塞障害改善機序. 日本薬学会年会要旨集. 2018. 138年会. 3. 95-95

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Lectures and oral presentations (83)：

Effects of KNT-127, a delta opioid receptor agonist, on non-REM sleep in mice.
(2022)
δオピオイド受容体作動薬KNT-127の睡眠に対する影響
(BPCNPNPPP4学会合同年会(第44回日本生物学的精神医学会年会/第32回日本臨床精神神経薬理学会年会/第52回日本神経精神薬理学会年会/第6回日本精神薬学会総会・学術集会) 2022)
Effects of KNT-127, a delta opioid receptor agonist, on sleep in mice
(2022)
炎症性疼痛における表皮内へ伸長した神経線維に対するシアル酸分解酵素の効果
(第95回日本薬理学会年会 2022)
スルファチドによる機械的アロディニアにおけるセレクチンシグナルの関与
(第95回日本薬理学会年会 2022)

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Education (2)：

1999 - 2001 Meijo University Graduate School, Division of Pharmaceutical Sciences Clinical Pharmacy
1995 - 1999 Meijo University Faculty of Pharmaceutical Science Department of Pharmaceutical Sciences

Professional career (1)：

Work history (4)：

2013/04 - Kitasato University Laboratory of Pharmacology
2011/11 - 2013/03 Kitasato University Laboratory of Medicinal Chemistry, School of Pharmacy
2008/10 - 2011/10 National Center of Neurology and Psychiatry Department of Neuropsychopharmacology
2001/04 - 2008/09 Tokyo University of Science Department of Pharmacology

Committee career (2)：

Association Membership(s) (4)：

日本薬理学会 , 日本神経精神薬理学会 , 日本薬学会 , 日本神経科学会

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