Rchr
J-GLOBAL ID：200901027566872440   Update date: Mar. 15, 2024

Nishimura Masaki

ニシムラ マサキ | Nishimura Masaki
Affiliation and department：
Shiga University of Medical Science Molecular Neuroscience Research Center, Shiga University of Medical Science Molecular Neuroscience Research Center

About Shiga University of Medical Science Molecular Neuroscience Research Center, Shiga University of Medical Science Molecular Neuroscience Research Center


Job title： Professor
Research field  (1)： Neuropathology
Research keywords  (1)： アルツハイマー病
Research theme for competitive and other funds  (12)：
  • 2022 - 2027 認知症予測の網羅的モデル開発のための一般集団における脳画像長期追跡疫学研究
  • 2019 - 2023 Development of preventive therapy for Alzheimer's disease by modification in expressional levels of the risk genes
  • 2019 - 2022 Identification of circulating factors triggering molecular pathological processes of Alzheimer's disease
  • 2014 - 2017 Neuron-specific mechanism for production and secretion of amyloid-beta and therapeutic regulation of its deposition
  • 2011 - 2015 Model animals by nonhuman primate for Alzheimer disease, hyper expression of mutant amyloid precursor protein and formation of senile plaques in the brain
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Papers (81)：
  • Yachiyo Mitsuishi, Masaki Nakano, Hirotatsu Kojima, Takayoshi Okabe, Masaki Nishimura. Reduction of Amyloid-β Production without Inhibiting Secretase Activity by MS-275. ACS chemical neuroscience. 2024
  • Masaki Nakano, Tomohiro Tsuchida, Yachiyo Mitsuishi, Masaki Nishimura. Nicotinic acetylcholine receptor activation induces BACE1 transcription via the phosphorylation and stabilization of nuclear SP1. Neuroscience research. 2023
  • 柳沢 大治郎, 守村 敏史, 西村 正樹, 遠山 育夫, 依馬 正次, 石垣 診祐. APPトランスジェニックカニクイザルの開発 脳脊髄液バイオマーカー. Dementia Japan. 2023. 37. 4. 711-711
  • Saori Hata, Haruka Saito, Takeharu Kakiuchi, Dai Fukumoto, Shigeyuki Yamamoto, Kensaku Kasuga, Ayano Kimura, Koichi Moteki, Ruriko Abe, Shungo Adachi, et al. Brain p3-Alcβ peptide restores neuronal viability impaired by Alzheimer's amyloid β-peptide. EMBO molecular medicine. 2023. 15. 5. e17052
  • Nakano M, Imamura R, Sugi T, Nishimura M. Human FAM3C restores memory-based thermotaxis of Caenorhabditis elegans famp-1/m70.4 loss-of-function mutants. PNAS Nexus. 2022. 1. 5. 1-11
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MISC (7)：
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Patents (2)：
  • Pharmacological composition for the treatment and/or prevention of disease involving abnormal accumulation of amyloid-beta protein
  • Pharmacological composition for the treatment and/or prevention of disease involving abnormal accumulation of amyloid  protein
Education (2)：
  • - 1996 Kyoto University Faculty of Medicine
  • - 1984 Kyoto University Faculty of Medicine Department of Medical Science
Professional career (1)：
  • 医学博士 (京都大学)
Work history (5)：
  • 2014 - 現在 Shiga University of Medical Science
  • 2007 - 2014 Shiga University of Medical Science Molecular Neuroscience Research Center
  • 1999 - 2007 Shiga University of Medical Science Molecular Neuroscience Research Center
  • 1997 - 1999 University of Toronto
  • professor
Awards (1)：
  • 1999 - Frist/Jus記念賞(Frist/Jus Memorial Prize)
Association Membership(s) (8)：
American Society for Biochemistry and Molecular Biology ,  Japan Society for Dementia Research ,  Society for Neuroscience ,  日本神経科学会 ,  日本生化学会 ,  日本分子生物学会 ,  日本神経学会 ,  日本神経病理学会
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