Shimizu Toru

Affiliation and department：
Job title： Visiting Professor
Other affiliations (2)：

Shantou University Medical College Visiting Professor
国立研究開発法人産業技術総合研究所東北センター外来研究員

Homepage URL (1)： http://db.tohoku.ac.jp/whois/detail/ea1ef4b248c8b94cd805054c0eae90c4.html

Research field (3)： Inorganic and coordination chemistry , Biophysics , Functional biochemistry

Research keywords (6)：無機生物化学 , タンパク質構造 , ヘムタンパク質 , Inorganic biochemistry , Protein structure , Heme proteins

Research theme for competitive and other funds (2)：

1976 - 1976 金属酵素の構造ー機能相関関係
1976 - 1976 Structure and function relationships of metallo enzymes

Papers (66)：

Toru Shimizu. Disruption of the dimerization interface of the sensing domain in the dimeric heme-based oxygen sensor AfGcHK abolishes bacterial signal transduction. Journal of Biological Chemistry. 2020
Toru Shimizu, Alzbeta Lengalova, Václav Martínek, Markéta Martínková. Heme: emergent roles of heme in signal transduction, functional regulation and as catalytic centres. Chemical Society Reviews. 2019
Martin Stranava, Petr Man, Tereza Skalova, Petr Kolenko, Jan Blaha, Veronika Fojtikova, Vaclav Martinek, Jan Dohnalek, Alzbeta Lengalova, Michal Rosulek, et al. Coordination and redox state-dependent structural changes of the heme-based oxygen sensor AfGcHK associated with intraprotein signal transduction. JOURNAL OF BIOLOGICAL CHEMISTRY. 2017. 292. 51. 20921-20935
Martin Stranava, Vaclav Martinek, Petr Man, Veronika Fojtikova, Daniel Kavan, Ondrej Vanek, Toru Shimizu, Marketa Martinkova. Structural characterization of the heme-based oxygen sensor, AfGcHK, its interactions with the cognate response regulator, and their combined mechanism of action in a bacterial two-component signaling system. PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS. 2016. 84. 10. 1375-1389
Veronika Fojtikova, Martina Bartosova, Petr Man, Martin Stranava, Toru Shimizu, Marketa Martinkova. Effects of hydrogen sulfide on the heme coordination structure and catalytic activity of the globin-coupled oxygen sensor AfGcHK. BIOMETALS. 2016. 29. 4. 715-729

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MISC (261)：

V. Fojtikova, M. Stranava, A. Lengalova, T. Shimizu, M. Martinkova. The role of heme as an important mediator of biochemical processes. FEBS JOURNAL. 2017. 284. 379-379
Toru Shimizu, Dongyang Huang, Fang Yan, Martin Stranava, Martina Bartosova, Veronika Fojtikova, Marketa Martinkova. Gaseous O-2, NO, and CO in Signal Transduction: Structure and Function Relationships of Heme-Based Gas Sensors and Heme-Redox Sensors. CHEMICAL REVIEWS. 2015. 115. 13. 6491-6533
Kentaro Mukai, Toru Shimizu, Jotaro Igarashi. Phosphorylation of a Heme-Regulated Eukaryotic Initiation Factor 2 alpha kinase Enhances the Interaction with Heat-Shock Protein 90 and Substantially Upregulates kinase Activity. PROTEIN AND PEPTIDE LETTERS. 2011. 18. 12. 1251-1257
Kenichi Kitanishi, Kazuo Kobayashi, Takeshi Uchida, Koichiro Ishimori, Jotaro Igarashi, Toru Shimizu. Identification and Functional and Spectral Characterization of a Globin-coupled Histidine Kinase from Anaeromyxobacter sp Fw109-5. JOURNAL OF BIOLOGICAL CHEMISTRY. 2011. 286. 41. 35522-35534
Samir F. El-Mashtoly, Minoru Kubo, Satoru Nakashima, Toru Shimizu, Teizo Kitagawa. Structural Dynamics of EcDOS Heme Domain Revealed by Time-Resolved Ultraviolet Resonance Raman Spectroscopy. JOURNAL OF PHYSICAL CHEMISTRY LETTERS. 2011. 2. 17. 2212-2217

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Books (8)：

酵素利用技術体系ー基礎・解析から改変・高機能化・産業利用までー
エヌ・ティー・エス 2010
Handbook of Porphyrin Science
World Science 2010
酵素利用技術体系ー基礎・解析から改変・高機能化・産業利用までー
エヌ・ティー・エス 2010
Handbook of Porphyrin Science
World Science 2010
P450の分子生物学第2版
講談社 2009

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Lectures and oral presentations (8)：

NO activation of a heme-regulated kinase: A paradigm for PAS protein intereactions with NO?
(Gordon Research Conference, Nitric Oxide 2005)
NO activation of a heme-regulated kinase: A paradigm for PAS protein intereactions with NO?
(Gordon Research Conference, Nitric Oxide 2005)
Structure and Function Relationships of a Heme-regulated Phosphodiesterase from Escherichia coli (Ec DOS)
(The 1st Pacific-Rim International Conference on Protein Science, Japan 2004)
Molecular mechanisms for the regulation of NO formation in neuronal nitric-oxide synthase
(The 3rd International Conference on the Biology, Chemistry and Therapeutic Applications of Nitric Oxide 2004)
Structure and Function Relationships of Heme-regulated Enzymes
(3rd Symposium on Advances in Bioinorganic Chemistry and 2nd Asian Biological Inorganic Chemistry Conference 2004)

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Works (6)：

イギリス生化学会誌 Biochemical Journal 編集委員
2005 -
Editorial Advisory Panel for Biochemical Journal
2005 -
NO合成酵素の活性発現におけるプテリンの役割
2001 - 2004
NO合成酵素の活性発現におけるプテリンの役割
2001 - 2004
アメリカ生化学・分子生物学会誌編集委員
2001 -

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Education (3)：

- 1976 Tohoku University Graduate School, Division of Natural Science
- 1970 Tohoku University Faculty of Science Department of Chemistry
- 1970 Tohoku University Faculty of Science

Professional career (1)：

Ph.D. (Tohoku University)

Work history (8)：

2012/04 - 現在 Tohoku University Professor Emeritus
1994/04 - 2012/03 Tohoku University Institute of Multidisciplinary Research for Advanced Materials, Division of Organic- and Bio-materials Research, Bioreaction Design Professor
1988 - 1994 東北大学反応化学研究所助教授
1994 - - 東北大学多元物質科学研究所教授
1981 - 1988 東北大学非水溶液化学研究所助手

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Awards (1)：

1992 - 日本化学会学術賞

Association Membership(s) (14)：

THE NEW YORK ACADEMY OF SCIENCES , 日本生物物理学会 , 日本化学会 , American Association for the Advancement of Science , 日本生化学会 , American Chemical Society , American Society for Biochemisty and Molecular Biology , THE NEW YORK ACADEMY OF SCIENCES , 日本生物物理学会 , 日本化学会 , American Association for the Advancement of Science , 日本生化学会 , American Chemical Society , American Society for Biochemisty and Molecular Biology

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