Okada Yoshinori

オカダヨシノリ | Okada Yoshinori

Affiliation and department：
Job title： Professor
Other affiliations (1)：

東北大学病院呼吸器外科

Homepage URL (2)： http://www2.idac.tohoku.ac.jp/dep/surg/index.html , http://db.tohoku.ac.jp/whois/e_detail/f84714f5246fbca220df05e1d2ee314f.html

Research field (1)： Respiratory surgery

Research keywords (3)： lung transplantation , lung cancer , thoracic surgery

Research theme for competitive and other funds (34)：

2022 - 2025 免疫逃避機構を応用した新たな肺移植の戦略
2022 - 2025 IL-36βの免疫チェックポイント阻害作用による新規肺がん治療法の開発
2022 - 2025 Development of pro-inflammatory treatment by cross-sectional control of aging lung metabolism and epigenetics
2021 - 2025 Novel Rat Model and Intervention for Elucidating the Molecular Mechanism in Chronic Postsurgical Pain
2021 - 2024 新規肺移植後免疫抑制療法の開発を目指した間葉系幹細胞由来の細胞外小胞の解析と応用

2021 - 2024 自然免疫とサブタイプに着目した慢性移植肺機能不全のメカニズム解明

2021 - 2024 肺葉移植戦略の確立 - 局所二酸化炭素濃度測定による肺葉機能評価 -

2019 - 2024 持続肺換気保存法を用いたドナー肺機能改善と長時間肺保存法の開発

2020 - 2023 体外肺灌流装置を用いたマージナルドナー肺の肺葉機能診断法の開発

2019 - 2023 心臓死ドナー肺をターゲットとした体外肺灌流装置を用いた肺機能回復法の開発

2019 - 2023 Why is prognosis of lung transplant recipient from elderly donors poor? –Elucidation of mechanisms and establishment of therapeutic intervention strategy-

2018 - 2022 Ex vivo wet lab training system by veterinarian and surgeon

2018 - 2021 A novel immunosuppresive therapy by Type 1 regulatory T cells after lung transplantation

2018 - 2021 Elucidation of the pathophysiology of pulmonary fibrosis and development of new treatments by applying metabolome analysis

2017 - 2020 Nrf2 plays a role in ischemia-reperfusion lung injury after lung transplantation

2016 - 2019 New preservation system for donor lung

2016 - 2019 Elucidation of pathophysiology of chronic rejection after lung transplantation and development of a novel therapeutic method through IL-17 pathway.

2016 - 2019 The effect of a novel cell therapy for chronic lung allograft dysfunction in animal models

2015 - 2017 Treatment of Lung Ischemia-reperfusion injury by Muse cells

2014 - 2017 Role of antioxidative transcription factor Nrf2 in strategies to protect against ischemia-reperfusion injury after lung transplantation

2012 - 2015 Prevention of acute and chronic lung allograft rejection by mesenchymal stem cells

2012 - 2014 Development of lung monitoring system for brain death donor

2011 - 2013 Therapeutic potency of Nrf2, a key antioxidative transcription factor, for pulmonary hypertension

2007 - 2009 Treatment for primary lung graft dysfunction by transfusion of endothelial progenitor cells transferred with intreleukin-10 gene.

2006 - 2008 Effect of trans-bronchial interleukin-10 gene transfer on prevention of lung allograft rejection

2005 - 2006 細胞内サイトカイン染色法を用いた肺移植レシピエント免疫監視システム開発の可能性

2005 - 2006 オステオポンチンは肺高血圧症の発症機序・病態生理に関与するか?

2003 - 2004 異種肺移植片に対するアコモデーション誘導遺伝子導入による生着延長効果の検討

2002 - 2004 Interleukin-10 Gene Transfer to The Airway of Rat Lungs for Prevention of Lung Allograft Rejection

2002 - 2004 An artificial lung of a new concept, development of hemoglobin with the high oxygen affinity

2002 - 2003 Study of Lung Preservation with Marginal Donor Lung

2000 - 2002 Liquid ventilation as a bridging to lung transplantation

2000 - 2002 ANALYSIS OF CLINICAL COURSE AND GENETIC NALTERATIONS OF THE PATIENTS WITH ROENTGENOGRAPHICALLY OCCULT SQUAMOUS CELL CARCINOMA OF THE LUNG

2000 - 2001 Allograft Rejection in FcR γ knockout mice

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Papers (547)：

Fumiko Tomiyama, Takaya Suzuki, Tatsuaki Watanabe, Jun Miyanaga, Anna Suzuki, Takayasu Ito, Sho Murai, Yuyo Suzuki, Hiromichi Niikawa, Hisashi Oishi, et al. Orthotopic transplantation of the bioengineered lung using a mouse-scale perfusion-based bioreactor and human primary endothelial cells. Scientific reports. 2024. 14. 1. 7040-7040
Takashi Hirama, Miki Akiba, Masahiro Ui, Saori Shibata, Fumiko Tomiyama, Tatsuaki Watanabe, Yui Watanabe, Hirotsugu Notsuda, Takaya Suzuki, Hisashi Oishi, et al. Long-term survival and clinical outcomes of delayed chest closure following lung transplantation. Surgery today. 2024
Takashi Hirama, Miki Akiba, Toshikazu Watanabe, Yui Watanabe, Hisashi Oishi, Yoshinori Okada. A Single-Center Analysis of How HLA Mismatch and Donor-Specific Antibodies Affect Short-Term Outcome After Lung Transplantation: A Pilot Study Before a Country-Wide Histocompatibility Study in Japan. Transplantation proceedings. 2024. 56. 2. 363-368
Hirotsugu Notsuda, Hiroki Oshio, Ken Onodera, Takashi Hirama, Yui Watanabe, Tatsuaki Watanabe, Takaya Suzuki, Hisashi Oishi, Hiromichi Niikawa, Ryoko Saito-Koyama, et al. Morphological Predictors of Primary Lung Cancer among Part-Solid Ground-Grass Nodules on High-Resolution CT. The Tohoku journal of experimental medicine. 2024
Takaya Suzuki, Hirotsugu Notsuda, Hisashi Oishi, Hiromichi Niikawa, Tatsuaki Watanabe, Yui Watanabe, Ken Onodera, Tetsuto Takeda, Ringo Sugawara, Masafumi Noda, et al. Evolution of Pleural Solitary Fibrous Tumors Causing Severe Hypoglycemia after Exceptionally Long Asymptomatic Periods: Report of Two Surgical Cases. The Tohoku journal of experimental medicine. 2024

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MISC (714)：

小山涼子, 村上圭吾, 村上一宏, 三木康宏, 井上千裕, 田畑俊治, 岡田克典, 鈴木貴, 鈴木博義, 笹野公伸. 間質性肺炎における浸潤性粘液性腺癌発生機序の検討. 日本病理学会会誌. 2023. 112. 1. 330-330
鈴木隆哉, 大石久, 新井川弘道, 野津田泰嗣, 渡辺有為, 渡邊龍秋, 小野寺賢, 野田雅史, 岡田克典. 胸腔鏡手術時代における降下性壊死性縦隔炎-疫学的特徴と手術予後. 日本胸部外科学会定期学術集会(Web). 2023. 76th
鈴木隆哉, 冨山史子, 岡田克典. Lung bioengineering using collective reprogramming of adult human lung cells. 月刊細胞. 2023. 55. 11
村井翔, 渡辺有為, 上田和典, 野田雅史, 小野寺賢, 渡邉龍秋, 平間崇, 野津田泰嗣, 鈴木隆哉, 大石久, et al. マルチ呼吸機能測定装置を用いた術中肺瘻評価方法の確立. 日本外科学会定期学術集会(Web). 2023. 123rd
大石久, 渡邉龍秋, 平間崇, 渡辺有為, 新井川弘道, 宇井雅博, 野田雅史, 鈴木隆哉, 野津田泰嗣, 小野寺賢, et al. 高難度脳死両肺移植と移植肺グラフトの長時間虚血に挑む. 日本移植学会総会プログラム抄録集. 2023. 59th (Web)

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Education (1)：

- 1988 Tohoku University Faculty of Medicine

Professional career (1)：

医学博士

Work history (9)：

2015/04 - 現在 Tohoku University Institute of Development, Aging and Cancer
2008/07 - 2015/03 Tohoku University Institute of Development, Aging and Cancer
2006/07 - 2008/06 東北大学病院呼吸器外科講師
2000/02 - 2006/06 Tohoku University Institute of Development, Aging and Cancer
1997/07 - 2000/01 Tohoku University Institute of Development, Aging and Cancer

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