Rchr
J-GLOBAL ID:200901028440136087
Update date: Apr. 15, 2024
Kazuko Kaneda-Nakashima
カネダーナカシマ カズコ | Kazuko Kaneda-Nakashima
Affiliation and department:
Job title:
Professor
Other affiliations (1):
-
Institute for Radiation Sciences
Radiation Science
Professor
Homepage URL (1):
https://www.frc.sci.osaka-u.ac.jp
Research field (4):
Tumor biology
, Radiology
, Immunology
, Medical biochemistry
Research keywords (9):
Zinc transporter
, Aminoacid transporter
, Alpha emitting nuclides
, Astatine-211
, Radiation
, 転写因子
, 白血病
, transcriptional factor
, Leukemia
Research theme for competitive and other funds (12):
- 2020 - 2023 Targeted alpha therapy for patients with tumor
- 2019 - 2022 Development of Nuclear Medicine Therapy targeting Cancer Stroma
- 2019 - 2021 Development of stable and rapid reactive chlating agent for MRI and Targeted Alpha Therapy
- 2018 - 2021 アミノ酸トランスポーターLAT1を標的とするα線がんミサイル療法の開発
- 2015 - 2017 Investigation of cancer specific survival system via LAT1/4F2hc-integrin complex
- 2013 - 2016 Analysis of ATL leukemogenesis through breakage of defense mechanism of HTLV-1 infection
- 2013 - 2015 Investigation of survival strategy of refractory leukemia via integrin
- 2012 - 2015 Investigation of MEL1/PRDM16 function in bone differentiation
- 2013 - 2013 新規白血病幹細胞マーカーを標的とした白血病治療法の検討
- 2011 - 2011 がん細胞接着阻害を利用した難治性白血病抗体療法の開発
- 2010 - 転写因子MEL1の新規機能解析
- 2010 - 転写因子EVI1を介した急性骨髄性白血病の発症メカニズムの解析
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Papers (63):
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Kazuko Kaneda-Nakashima, Yoshifumi Shirakami, Yuichiro Kadonaga, Tadashi Watabe, Kazuhiro Ooe, Xiaojie Yin, Hiromitsu Haba, Kenji Shirasaki, Hidetoshi Kikunaga, Kazuaki Tsukada, et al. Comparison of Nuclear Medicine Therapeutics Targeting PSMA among Alpha-Emitting Nuclides. International Journal of Molecular Sciences. 2024. 25. 2. 933-933
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Tadashi Watabe, Kazuya Kabayama, Sadahiro Naka, Ryuku Yamamoto, Kazuko Kaneda, Satoshi Serada, Kazuhiro Ooe, Atsushi Toyoshima, Yang Wang, Hiromitsu Haba, et al. Immuno-PET and Targeted α-Therapy Using Anti-Glypican-1 Antibody Labeled with89Zr or211At: A Theranostic Approach for Pancreatic Ductal Adenocarcinoma. Journal of Nuclear Medicine. 2023. jnumed.123.266313-jnumed.123.266313
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Zitong Shi, Kazuko Kaneda-Nakashima, Ryuichi Ohgaki, Minhui Xu, Hiroki Okanishi, Hitoshi Endou, Shushi Nagamori, Yoshikatsu Kanai. Inhibition of Cancer-type Amino Acid Transporter LAT1 Suppresses B16-f10 Melanoma Metastasis in Mouse Models. Scientific Reports. 2023. 13. 1. 13943-13943
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Ayaka Aso, Hinako Nabetani, Yoshifumi Matsuura, Yuichiro Kadonaga, Yoshifumi Shirakami, Tadashi Watabe, Taku Yoshiya, Masayoshi Mochizuki, Kazuhiro Ooe, Atsuko Kawakami, et al. Evaluation of Astatine-211-Labeled Fibroblast Activation Protein Inhibitor (FAPI): Comparison of Different Linkers with Polyethylene Glycol and Piperazine. International Journal of Molecular Sciences. 2023. 24. 10. 8701-8701
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Kazuko Kaneda-Nakashima, Yoshifumi Shirakami, Yuichiro Kadonaga, Tadashi Watabe. Fibroblast Activation Protein Inhibitor Theranostics: Preclinical Considerations. PET clinics. 2023. 18. 3. 397-408
more...
MISC (28):
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兼田(中島) 加珠子, 樺山 一哉, 白神 宜史, 渡部 直史, 豊嶋 厚史, 深瀬 浩一. 進行がんや手術困難例に対する核医学治療薬の現状と新規治療薬の開発-Development of nuclear medicine for targeting alpha therapy to cancer. 臨床免疫・アレルギー科 = Clinical immunology & allergology / 臨床免疫・アレルギー科編集委員会 編. 2023. 79. 3. 348-352
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渡部 直史, 兼田 加珠子, 豊嶋 厚史, 深瀬 浩一. アスタチン(211At)標識PSMA5を用いた新規標的α線治療の評価 前立腺癌モデルでの検討(Evaluation of new targeted alpha therapy using astatine(211At) labeled PSMA5 for prostate cancer). 日本癌学会総会記事. 2022. 81回. J-1007
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Kazuko Kaneda-Nakashima, Yoshiyuki Manabe, Atsushi Shimoyama, Kazuya Kabayama, Yoshikatsu Kanai, Atsushi Toyoshima, Atsushi Shinohara, Koichi Fukase. Development of short-lived alpha-emitting nuclear medicine aiming at minimally invasive cancer treatment. 日本癌学会総会記事. 2022. 81回. J-1008
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渡部 直史, 兼田 加珠子, 白神 宜史, 角永 悠一郎, 大江 一弘, 王 洋, 羽場 宏光, 豊嶋 厚史, 深瀬 浩一. 211At標識PSMA-5を用いた標的アルファ線治療 非臨床での評価. 核医学. 2022. 59. Suppl. S464-S464
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Kabayama Kazuya, Shirakami Yoshifumi, Kaneda Kazuko, Watabe Tadashi, Toyoshima Atsushi. Activities of Targeted Alpha Therapy at Osaka University. MEDCHEM NEWS. 2022. 32. 2. 93-98
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Patents (15):
Lectures and oral presentations (53):
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還元剤による[211At]NaAtの調製とイオン対逆相HPLC分析
(第60回日本核医学会総会学術集会)
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Development of targeted alpha therapy with 225-actinium
(GIMRT Joint International Symposium on Radiation Effects in Materials and Actinide Science: GIMRT-REMAS2020)
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核医学利用に向けたアスタチン化ナトリウム,[211At]NaAtの高純度調製
(日本放射化学会第64回討論会 2020)
-
がん細胞型アミノ酸トランスポータを標的としたAt-211標識核医学治療薬の検討
(日本放射化学会第64回討論会 2020)
-
がん間質を標的とするα線治療薬255Ac-FAPI-04の研究
(第3回放射性薬品科学研究会/第19回放射性医薬品・画像診断薬研究会 2019)
more...
Works (5):
-
インテグリンを介した白血病残存戦略の解明
2013 - 2015
-
MEL1/PRDM16による骨分化制御機構の解明
2012 - 2015
-
新規白血病幹細胞マーカーを標的とした白血病治療法の検討
2013 - 2014
-
がん細胞接着阻害を利用した難治性白血病治療抗体の開発
2013 - 2013
-
がん細胞接着阻害を利用した難治性白血病抗体療法の開発
2011 - 2012
Education (7):
- 2003 - 2006 Kyoto University Graduate School of Medicine
- - 2006 Kyoto University Graduate School, Division of Medicine
- 2001 - 2002 Osaka University Graduate School of Medicine
- 1999 - 2001 Osaka University Graduate School of Medicine
- - 2001 Osaka University Graduate School, Division of Medical Sciences
- 1995 - 1999 Osaka University Faculty of Human Sciences Bihavioral Sciences
- - 1999 Osaka University Faculty of Human Science Human Science, Behavioral Sciences
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Professional career (2):
- Doctor of Public Health (Kyoto University)
- Medical Science (Osaka University)
Work history (10):
- 2022/04 - 現在 Graduate School of Science, Osaka University Forfront Research Center Professor
- 2018/12 - 2022/03 Osaka University Institute for Radiation Sciences Associate Professor
- 2017/03 - 2018/12 Osaka University Graduate School of Science Assistant professor
- 2014/09 - 2017/03 Osaka University Graduate School of Medicine, Assistant professor
- 2010/04 - 2015/03 University of Miyazaki Faculty of Medicine Assistant professor
- 2010/04 - 2015/03 Assistant Professor,Function control study course tumor biochemistry field,School of Madicine,Faculty of Madicine,University of Miyazaki
- 2008/04 - 2010/03 Osaka University Graduate School of Frontier Biosciences Postdoctoral fellow
- 2008/04 - 2010/03 Researcher,Osaka University
- 2006/04 - 2008/03 National Institute of Biomedical Innovation Laboratory of Gene Transfer and Regulation Postdoctoral fellow
- 2006/04 - 2008/03 Researcher
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Committee career (1):
- 2015/02 - 現在 トランスポーター研究会 幹事
Awards (5):
- 2022/09 - Dispersion of alpha-nuclides during Animal Experiments Japanese society of radiation safety management Technology award
- 2018/12 - 日本放射線安全管理学会 日本放射線安全管理学会 第17回 学術大会 優秀ポスター賞 動物実験における短寿命アルファ線核種の体内外の分布
- 2014/12 - 日本血液学会 第76回日本血液学会学術総会優秀ポスター賞
- 2012/10 - 日本血液学会 第74回日本血液学会学術総会優秀ポスター賞
- 2010/09 - 日本血液学会 第72回日本血液学会学術総会優秀ポスター賞
Association Membership(s) (7):
日本生化学会
, 日本血液学会
, 日本癌学会
, 日本分子生物学会
, 日本免疫学会
, 日本アレルギー学会
, JAPANESE SOCIETY OF RADIATION SAFETY MANAGEMENT
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