Seki Yoshiyuki

セキヨシユキ | Seki Yoshiyuki

Affiliation and department：
Job title： Professor
Homepage URL (1)： http://seki-lab.wixsite.com/seki-lab

Research field (2)： Developmental biology , Genomics

Research keywords (3)：幹細胞生物学 , 生殖細胞生物学 , エピジェネティクス

Research theme for competitive and other funds (23)：

2022 - 2024 DUX非依存的な新規2細胞様細胞の可視化による胚性ゲノム活性化機構の解明
2020 - 2022 DUXに依存しない胚性ゲノム活性化による全能性獲得機構の解明
2018 - 2022 Evolutional origin and transformation of transcriptional networks for the conversion from pluripotent cells into primordial germ cells
2020 - 2022 DUXに依存しない胚性ゲノム活性化による全能性獲得機構の解明
2018 - 2021 A study on qualitative spatial representation and reasoning system focused on the change of shapes

2015 - 2019 PRDM14による塩基除去修復を介した能動的脱メチル化機構の解明

2016 - 2018 Molecular mechanism and artificial regulation of epigenetic reprogramming in primordial germ cells

2016 - 2018 Common and species-specific molecular principles for the establishment of germ cell fate

2016 - 2018 生殖細胞形成機構の動物種を超えた共通原理と種特異性

2016 - 2018 始原生殖細胞によるエピゲノムリプログラミングとその人為的制御

2015 - 2018 Molecular mechanisms of base excision repaired-mediated DNA demethylation driven by PRDM14 (Fostering Joint International Research)

2014 - 2016 始原生殖細胞によるエピゲノムリプログラミング

2012 - 2016 Elucidation of molecular mechanism for base excision repair pathway-mediated active demethylation by PRDM14

2014 - 2016 始原生殖細胞によるエピゲノムリプログラミング (研究課題番号:26112514)

2011 - 2013 始原生殖細胞におけるエピゲノムリプログラミングが保証する生命機能の同定

2010 - 2012 始原生殖細胞による細胞増殖を介したエピゲノム情報の希釈と減数分裂能の獲得

2011 - 2012 始原生殖細胞におけるエピゲノムリプログラミングが保証する生命機能の同定

2009 - 2011 始原生殖細胞によるエピゲノム再編成機構の解明

2010 - 2011 始原生殖細胞による細胞増殖を介したエピゲノム情報の希釈と減数分裂能の獲得

2009 - 2010 始原生殖細胞によるエピゲノム再編成機構の解明

2008 - 2009 Epigenetic reprogramming associated with specification and early development of primordial germ cells.

2006 - 2007 全能性の再確立に関わる始原生殖細胞の核内基盤の解明

2005 - 2005 個体発生能に関わる始原生殖細胞の核内基盤の解明

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Papers (24)：

Maiko Yamamoto, Yoshiaki Suwa, Kohta Sugiyama, Naoki Okashita, Masanori Kawaguchi, Naoki Tani, Kazumi Matsubara, Akira Nakamura, Yoshiyuki Seki. The PRDM14-CtBP1/2-PRC2 complex regulates transcriptional repression during the transition from primed to naïve pluripotency. Journal of cell science. 2020. 133. 15
Masanori Kawaguchi, Kota Sugiyama, Kazumi Matsubara, Che-Yi Lin, Shigehiro Kuraku, Shota Hashimoto, Yoshiaki Suwa, Luok Wen Yong, Koji Takino, Shota Higashida, et al. Co-option of the PRDM14-CBFA2T complex from motor neurons to pluripotent cells during vertebrate evolution. Development (Cambridge, England). 2019. 146. 2
Yukimasa Shibata, Yoshiyuki Seki, Kiyoji Nishiwaki. Maintenance of cell fates and regulation of the histone variant H3.3 by TLK kinase in Caenorhabditis elegans. Biology Open. 2019
Yoshiyuki Seki. PRDM14 is a unique epigenetic regulator stabilizing transcriptional networks for pluripotency. Frontiers in Cell and Developmental Biology. 2018. 6
Naoki Okashita, Yoshiaki Suwa, Osamu Nishimura, Nao Sakashita, Mitsutaka Kadota, Go Nagamatsu, Masanori Kawaguchi, Hiroki Kashida, Ayaka Nakajima, Makoto Tachibana, et al. PRDM14 Drives OCT3/4 Recruitment via Active Demethylation in the Transition from Primed to Naive Pluripotency. Stem Cell Reports. 2016. 7. 6. 1072-1086

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MISC (2)：

関由行, 岡下修己. 始原生殖細胞によるエピゲノムリプログラミング. Journal of mammalian ova research = 日本哺乳動物卵子学会誌. 2013. 30. 3. 95-100
OMary Ann Suico, Hiroki Yoshida, Yoshiyuki Seki, Tomoko Uchikawa, Zhou Lu, Tsuyoshi Shuto, Kazuhito Matsuzaki, Mitsuyoshi Nako, Hirofumi Kai. MEF, an ETS transcription factor, up-regulates lysozyme transcription in epithelial cells through interaction with PML protein. CELL STRUCTURE AND FUNCTION. 2004. 29. 71-71

Patents (1)：

Books (3)：

Epigenetic Reprogramming Associated with Primordial Germ Cell Development, Epigenetics and Human Reproduction (Epigenetics and Human Health)
Springer; 1st Edition 2010
哺乳類の生殖細胞形成を制御する分子機構, 実験医学, 2月号
羊土社 2009
Epigenetic reprogramming in primordial germ cell development. Genetical and epigenetical control of mammalian germ cell development and their function. Genetic and epigenetic control of mammalian germ cell development and function.
Research Signpost, 13-36 2008

Lectures and oral presentations (2)：

始原生殖細胞によるエピゲノム変異の修復とその破綻
(第40回環境変異原学会 2011)
生命の連続性を保証する生殖細胞特異的なエピゲノム調節とその破綻
(文部科学省・大学教育改革支援プログラム「社会の要求に応える動物生命工学の実践教育」 2009)

Professional career (1)：

Work history (2)：

2021/04/01 - 現在 Kwansei Gakuin University School of Biological and Environmental Sciences Professor
2009/04/01 - 2021/03/31 Kwansei Gakuin University School of Science and Technology Department of Bioscience Associate Professor

Awards (1)：

Association Membership(s) (4)：

日本進化学会 , 日本遺伝学会 , 日本分子生物学会 , 日本エピジェネティクス研究会

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