Rchr
J-GLOBAL ID：200901028713040053
Update date: Feb. 01, 2024
Kawahara Sachiyo
カワハラ サチヨ | Kawahara Sachiyo
Affiliation and department：
Research field (3)：
Immunology
, Virology
, Experimental pathology
Research keywords (4)：
液性免疫
, 感染免疫
, ワクチン
, レトロウイルス
Research theme for competitive and other funds (13)：
- 2023 - 2026 B細胞におけるAPOBEC3の発現誘導機構及びその分子機能の解明
- 2022 - 2025 Mechanisms of B-lymphomagenesis in the absence of APOBEC3 cytidine deaminase
- 2016 - 2019 The requirement of B cell-intrinsic TLR7 for the protection of retrovirus-induced leuchemia
- 2013 - 2016 Retroviral immune evasion
- 2012 - 2015 Mechanisms of regulation of host immune responses by retrovirus-restricting enzyme APOBEC3
- 2010 - 2012 The role of mouse APOBEC3 in the regulation of endogenous retrovirus
- 2009 - 2011 Regulation of APOBEC3 gene expression and its transcript splicing
- 2009 - 2011 Analysis of the neuropathogenic mechanisms induced by the antiganglioside antibodies : the effect on signal transduction in neurons
- 2005 - 2006 Mechanisms of the control of chromosome 22 gene expression associated with HIV-1-exposed but uninfected status
- 2003 - 2004 Analyses of host genes that confer immune resistance against human immunodeficiency virus type-1 infection in HIV-1-exposed but uninfected individuals in the overseas cohorts
- 2003 - 2004 細胞傷害性Tリンパ球はウイルス感染防御に必要か
- 2001 - 2002 Structural analysis of protective and non-protective T-cell epitopes encoded with in the retroviral gag gene product
- 1998 - 1999 リンパ球の「生か死か」を決定する抗原受容体シグナル伝達機構の解明
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Papers (39)：
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Kenta Teruya, Ayumi Oguma, Satoko Takahashi, Miki Watanabe-Matsui, Sachiyo Tsuji-Kawahara, Masaaki Miyazawa, Katsumi Doh-ura. Anti-prion activity of cellulose ether is impaired in mice lacking pre T-cell antigen receptor α, T-cell receptor δ, or lytic granule function. International Immunopharmacology. 2022. 107. 108672-108672
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Shota Tsukimoto, Yoshiyuki Hakata, Sachiyo Tsuji-Kawahara, Takuji Enya, Tetsuo Tsukamoto, Seiya Mizuno, Satoru Takahashi, Shinichi Nakao, Masaaki Miyazawa. Distinctive High Expression of Antiretroviral APOBEC3 Protein in Mouse Germinal Center B Cells. Viruses. 2022. 14. 4
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Tsukamoto T, Tsuji-Kawahara S, Miyazawa M. The mechanisms for leukemogenesis in Friend virus-infected mice. Bio Clinica. 2019. 34. 6. 629-635
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C. Motozono, S. Tsuji-Kawahara, S. Takamura, M. Miyazawa. Vaccine-elicited preferential induction of polyfunctional Th cells is associated with protection against acute retroviral infection. EUROPEAN JOURNAL OF IMMUNOLOGY. 2016. 46. 817-817
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Masaaki Miyazawa, Yoshiyuki Hakata, Eri Takeda, Jun Li, Sachiyo Tsuji-Kawahara. Functional polymorphisms and molecular evolution of mouse APOBEC3. Seikagaku. 2016. 88. 5. 582-592
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MISC (3)：
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小川達也, 鷹羽浄顕, 佐賀俊彦, 北山仁士, 金田敏夫, 中本進, 井村正人, 札琢磨, 藤井公輔, 西野貴子, et al. Least Invasive Circulation Systemを用いたCABG低侵襲化戦略-分子生物学的観点から. 日本冠動脈外科学会学術大会講演抄録集. 2012. 17th
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宮澤 正顯, 岩波 礼将, 丹羽 淳子, 河原 佐智代, 菅原 大輔. レトロウイルスgag抗原上の感染防御エピトープとペプチドワクチン投与マウスで誘導されるエフェクター機構の解析. 厚生科学研究費補助金エイズ対策研究事業 HIV感染予防に関する研究 平成12年度 総括・分担研究報告書. 2002. 72-78
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Chicken T cell receptors. Bull. Soc. Fr.-Jpn. Sci. Vet. 1995. 6. 2. 45-49
Lectures and oral presentations (18)：
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B細胞固有TLR7シグナル伝達はレトロウイルス感染後の組換えウイルス産生防止にとって必要である
(日本免疫学会総会・学術会記録 2015)
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Production of virus-neutralizing antibodies and protection against lethal retroviral infection in AID-deficient mice.
(2011)
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Polymorphisms in mouse APOBEC3 influence the production of virus-neutralizing antibodies by altering the levels of retrovirus-induced B-cell dysfunction
(2010)
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Polymorphisms of both APOBEC3 and BAFF-R affect the production of retrovirus-neutralizing antibodies
(2009)
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生理的に発現するマウスAPOBEC3アイソフォームのフレンド白血病ウイルス複製抑制活性
(第55回日本ウイルス学会学術集会 2007)
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Education (4)：
- 1991 - 1996 Osaka Prefecture University
- 1993 - 1995 アラバマ大学医学部(Max D. Cooper博士)
- 1987 - 1989 Osaka Prefecture University
- - 1987 Osaka Prefecture University Faculty of Agriculture
Professional career (1)：
- Veterinary medicine (Osaka Prefecture University)
Work history (7)：
Association Membership(s) (3)：
アメリカ微生物学会
, 日本分子生物学会
, 日本免疫学会
