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J-GLOBAL ID：200901028740860330   Update date: Apr. 22, 2024

Yamamoto Chika

ヤマモト チカ | Yamamoto Chika
Affiliation and department：
Toho University Faculty of Pharmaceutical Sciences

About Toho University Faculty of Pharmaceutical Sciences


Job title： Associate Professor
Homepage URL  (1)： https://www.c-yamamoto.phar.toho-u.ac.jp/
Research field  (2)： Pharmaceuticals - health and biochemistry ,  Environmental effects of chemicals
Research keywords  (5)： Proteoglycans ,  血管内皮細胞の機能調節 ,  重金属毒性 ,  Regulation of Vascular Endothelial Cell Functions ,  Heavy Metal Toxicity
Research theme for competitive and other funds  (14)：
  • 2018 - 2021 Intracellular signal pathways that are involved in the regulation of fibrinolysis by vascular endothelial cells
  • 2015 - 2018 Analysis of molecular mechanisms for vascular endothelial perlecan synthesis by the strategy of bio-organometallices
  • 2012 - 2016 Regulation of vascular endothelial cell functions and exhibition of heavy metal toxicity through zinc transporter expression
  • 2011 - 2014 Modification of organometallic compound cytotoxicity by incorporated metal atoms and molecular mechanisms underlying the toxicity
  • 2006 - 2010 Abnormal proteoglycan metabolism as a target of neurotoxicity of mechylmercury
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Papers (206)：
  • Tomoya Fujie, Miyabi Kobayashi, Lihito Ikeuchi, Tsuyoshi Nakano, Kazuki Kitabatake, Yo Shinoda, Yasuyuki Fujiwara, Chika Yamamoto, Mitsutoshi Tsukimoto, Toshiyuki Kaji. Transcriptome analysis of cultured human vascular endothelial cells after γ-ray irradiation and correlation analysis with ATP, ADP, and adenosine as secondary soluble factors. The Journal of Toxicological Sciences. 2024. 49. 4. 193-208
  • Takato Hara, Reina Kumagai, Tohru Tanaka, Tsuyoshi Nakano, Tomoya Fujie, Yasuyuki Fujiwara, Chika Yamamoto, Toshiyuki Kaji. Lead suppresses perlecan expression via EGFR-ERK1/2-COX-2-PGI2 pathway in cultured bovine vascular endothelial cells. The Journal of Toxicological Sciences. 2023. 48. 12. 655-663
  • Ke Du, Takashi Hirooka, Yu Sasaki, Akira Yasutake, Takato Hara, Chika Yamamoto, Yasuyuki Fujiwara, Yo Shinoda, Tomoya Fujie, Shogo Katsuda, et al. Pathogenesis of selective damage of granule cell layer in cerebellum of rats exposed to methylmercury. The Journal of Toxicological Sciences. 2023. 48. 7. 429-439
  • Takato Hara, Tomoko Konishi, Shuji Yasuike, Yasuyuki Fujiwara, Chika Yamamoto, Toshiyuki Kaji. Sb-Phenyl-N-methyl-5,6,7,12-tetrahydrodibenz[c,f][1,5]azastibocine Induces Perlecan Core Protein Synthesis in Cultured Vascular Endothelial Cells. International Journal of Molecular Sciences. 2023. 24. 4. 3656-3656
  • Takato Hara, Shogo Matsuura, Keita Aikawa, Misaki Shirai, Mai Yoshida, Toshiyuki Kaji, Chika Yamamoto. Cadmium induces chondroitin sulfate synthase 1 via protein kinase Cα and elongates chondroitin/dermatan sulfate chains in cultured vascular endothelial cells. The Journal of toxicological sciences. 2023. 48. 8. 457-467
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MISC (16)：
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Books (5)：
  • スタンダード薬学シリーズII 薬学演習I(スタンダード薬学シリーズII-9)
    東京化学同人 2020 ISBN:9784807917235
  • コンパス衛生薬学(改訂第3版): 健康と環境(鍜冶利幸・佐藤雅彦編集)
    南江堂 2020 ISBN:9784524403714
  • スタンダード薬学シリーズ II 5 衛生薬学 : 健康と環境(日本薬学会編)
    東京化学同人 2019 ISBN:9784807917112
  • コンパス衛生薬学(改訂第2版): 健康と環境(鍜冶利幸・佐藤雅彦編集)
    南江堂 2016 ISBN:9784524403226
  • 保健環境論
    京都廣川書店 2014 ISBN:9784906992355
Works (4)：
  • Joint Research on the Biological Activities of Sodium Spirulan
    2000 -
  • 血管細胞プロテオグリカンに関する共同研究
    1994 -
  • Joint Research on Proteoglycans in Vascular cells
    1994 -
  • ナトリウムスピルランの生物活性に関する共同研究
Education (2)：
  • 1997 - 博士(薬学)学位取得 富山医科薬科大学
  • - 1990 Hokuriku University Faculty of Pharmaceutical Sciences Department of Hygienic Pharmacy
Professional career (1)：
  • (BLANK) (*Toyama Medical and Pharmaceutical University*)
Work history (9)：
  • 2017/04 - 現在 東京理科大学客員教授
  • 2013/04 - 現在 Toho University Faculty of Pharmaceutical Sciences
  • 2013/04 - 2017/03 東京理科大学 総合研究機構 客員教授(兼任)
  • 2012/04 - 2013/03 東京理科大学 総合研究機構 客員准教授(兼任)
  • 2007/05 - 2013/03 Hokuriku University Faculty of Pharmaceutical Sciences
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Committee career (13)：
  • 2022/07 - 現在 日本毒性学会 学術広報委員会 学術小委員会委員
  • 2022/07 - 現在 日本毒性学会 財務委員
  • 2022/07 - 現在 日本毒性学会 理事
  • 2020/03 - 現在 日本薬学会 代議員
  • 2014/01 - 現在 日本毒性学会 編集委員会委員 The Journal of Toxicological Sciences
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Awards (4)：
  • 2022/07 - Pfizer Highly Cited Paper Award Possible mechanisms underlying transcriptional induction of metallothionein isoforms by tris(pentafluorophenyl)stibane, tris(pentafluorophenyl)arsane, and tris(pentafluorophenyl)phosphane in cultured bovine aortic endothelial cells. The Journal of Toxicological Sciences, Vol.44, No.5, 327-333, 2019.
  • 2022/07 - Pfizer Highly Cited Paper Award Intracellular accumulation-independent cytotoxicity of pentavalent organoantimony compounds in cultured vascular endothelial cells. The Journal of Toxicological Sciences, Vol.44, No.12, 845-848, 2019.
  • 2018/07 - Pfizer Highly Cited Paper Award The cytotoxicity of organobismuth compounds with certain molecular structures can be diminished by replacing the bismuth atom with an antimony atom in the molecules. J. Toxicol. Sci. Vol.40, No.3, 321-327, 2015
  • 2005/10 - 日本薬学会 環境・衛生部会 環境・衛生部会賞 動脈硬化の進展メカニズムと防御に関する衛生薬学的研究
Association Membership(s) (5)：
日本糖質学会 ,  日本生化学会 ,  日本結合組織学会 ,  日本薬学会 ,  THE JAPANESE SOCIETY OF TOXICOLOGY
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