Hirota Tsuyoshi

ヒロタツヨシ | Hirota Tsuyoshi

Affiliation and department：
Job title： Designated Associate Professor
Homepage URL (2)： http://www.itbm.nagoya-u.ac.jp/ja/kay-hirota_group/ , http://www.itbm.nagoya-u.ac.jp/en/kay-hirota_group/

Research field (1)： Functional biochemistry

Research theme for competitive and other funds (9)：

2021 - 2024 革新的な機能調節化合物の創製による概日時計システムの統合的な理解と制御
2020 - 2023 ケージド時計調節化合物を用いた概日リズムの光制御と細胞間相互作用の解析
2020 - 2023 Mechanistic study on circadian clock system regulated by heme/CO crosstalk
2018 - 2021 Isoform selectivity of circadian clock proteins CRY1 and CRY2 analyzed by new chemical tools
2018 - 2020 Development and characterization of small molecules for analysis of circadian rhythm amplitude

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Papers (59)：

Aya Ogata, Takashi Yamada, Saori Hattori, Hiroshi Ikenuma, Junichiro Abe, Mari Tada, Masanori Ichise, Masaaki Suzuki, Kengo Ito, Takashi Kato, et al. Development of a novel PET ligand, [11C]GO289 targeting CK2 expressed in the brain. Bioorganic & medicinal chemistry letters. 2023. 90. 129327-129327
Christian Borgo, Luca Cesaro, Tsuyoshi Hirota, Keiko Kuwata, Claudio D'Amore, Thomas Ruppert, Renata Blatnik, Mauro Salvi, Lorenzo A Pinna. Analysis of the phosphoproteome of CK2α(-/-)/Δα' C2C12 myoblasts compared to the wild-type cells. Open biology. 2023. 13. 2. 220220-220220
Simon Miller, Manish Kesherwani, Priscilla Chan, Yoshiko Nagai, Moeri Yagi, Jamie Cope, Florence Tama, Steve A Kay, Tsuyoshi Hirota. CRY2 isoform selectivity of a circadian clock modulator with antiglioblastoma efficacy. Proceedings of the National Academy of Sciences of the United States of America. 2022. 119. 40. e2203936119
Moeri Yagi, Simon Miller, Yoshiko Nagai, Shinsuke Inuki, Ayato Sato, Tsuyoshi Hirota. A methylbenzimidazole derivative regulates mammalian circadian rhythms by targeting Cryptochrome proteins. F1000Research. 2022. 11. 1016-1016
Takahiro N Uehara, Takashi Nonoyama, Kyomi Taki, Keiko Kuwata, Ayato Sato, Kazuhiro J Fujimoto, Tsuyoshi Hirota, Hiromi Matsuo, Akari E Maeda, Azusa Ono, et al. Phosphorylation of RNA Polymerase II by CDKC;2 Maintains the Arabidopsis Circadian Clock Period. Plant & cell physiology. 2022. 63. 4. 450-462

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MISC (12)：

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Education (2)：

1998 - 2003 The University of Tokyo Grasuate School of Science Department of Biophysics and Biochemistry
1996 - 1998 The University of Tokyo School of Science Department of Biophysics and Biochemistry

Professional career (2)：

Work history (9)：

2014/05 - 現在 Nagoya University Institute of Transformative Bio-Molecules Designated Associate Professor
2014/10 - 2018/03 Japan Science and Technology Agency PRESTO Researcher (concurrent)
2013/07 - 2014/04 University of Southern California Research Associate
2012/07 - 2013/07 UC San Diego Associate Research Specialist
2008/10 - 2012/06 UC San Diego Assistant Research Specialist

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