Rchr
J-GLOBAL ID：200901030135556828   Update date: Apr. 04, 2024

Shigematsu Hideki

シゲマツ ヒデキ | Shigematsu Hideki
Affiliation and department：
Japan Synchrotron Radiation Research Institute Structural Biology Division

About Japan Synchrotron Radiation Research Institute Structural Biology Division


Job title： Research Scientist
Other affiliations (2)：
  • RIKEN  RIKEN SPring-8 Center 
  • Kobe University  Graduate School of Medicine   visiting professor
Homepage URL  (2)： http://stbio.spring8.or.jp/ ,  http://stbio.spring8.or.jp/index_en.php
Research field  (2)： Biophysics ,  Bio-, chemical, and soft-matter physics
Research keywords  (3)： membrane proteins ,  ion channel ,  electron cryo-microscopy
Research theme for competitive and other funds  (3)：
  • 2018 - 2021 電位依存性チャネルの作動原理の直接観察
  • 2017 - 2019 膜蛋白質の速くて複雑な動的機能構造を活写するハイブリッド構造解析基盤
  • 2015 - 2017 AMPA型グルタミン酸受容体の速くて複雑な動的構造の活写
Papers (61)：
  • Zengwei Liao, Chai C. Gopalasingam, Masafumi Kameya, Christoph Gerle, Hideki Shigematsu, Masaharu Ishii, Takatoshi Arakawa, Shinya Fushinobu. Structural insights into thermophilic chaperonin complexes. Structure. 2024
  • Mayuki Tanaka, Takeshi Yokoyama, Hironori Saito, Madoka Nishimoto, Kengo Tsuda, Naoyuki Sotta, Hideki Shigematsu, Mikako Shirouzu, Shintaro Iwasaki, Takuhiro Ito, et al. Boric acid intercepts 80S ribosome migration from AUG-stop by stabilizing eRF1. Nature Chemical Biology. 2024
  • Kazuhiro Abe, Mami Ozako, Miki Inukai, Yoe Matsuyuki, Shinnosuke Kitayama, Chisato Kanai, Chiaki Nagai, Chai C. Gopalasingam, Christoph Gerle, Hideki Shigematsu, et al. Deep learning driven de novo drug design based on gastric proton pump structures. Communications Biology. 2023. 6. 1
  • Hanako Ishimaru, Mitsuhiro Nishimura, Lidya Handayani Tjan, Silvia Sutandhio, Maria Istiqomah Marini, Gema Barlian Effendi, Hideki Shigematsu, Koji Kato, Natsumi Hasegawa, Kaito Aoki, et al. Identification and Analysis of Monoclonal Antibodies with Neutralizing Activity against Diverse SARS-CoV-2 Variants. Journal of virology. 2023. e0028623
  • Kentaro Sakaniwa, Akiko Fujimura, Takuma Shibata, Hideki Shigematsu, Toru Ekimoto, Masaki Yamamoto, Mitsunori Ikeguchi, Kensuke Miyake, Umeharu Ohto, Toshiyuki Shimizu. TLR3 forms a laterally aligned multimeric complex along double-stranded RNA for efficient signal transduction. Nature Communications. 2023. 14. 1
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MISC (11)：
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Lectures and oral presentations  (30)：
  • C型肝炎IRESは翻訳中80Sリボソームに結合し,宿主の翻訳系をハイジャックする。
    (日本RNA学会年会 2018)
  • MAP4のクライオ電子線顕微鏡解析による微小管の安定性,キネシン輸送制御機構の解明
    (日本分子生物学会年会プログラム・要旨集(Web) 2018)
  • クライオ電顕による電位依存性チャネルの作動原理の可視化
    (日本分子生物学会年会 2018)
  • クライオ電子顕微鏡が明らかにする膜蛋白質機能構造
    (日本薬学会関東支部大会講演要旨集 2017)
  • 高濃度ホウ素存在下によって最小open reading frameで停止したリボソームの生化学的解析
    (日本RNA学会年会要旨集 2017)
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Education (2)：
  • - 1999 Tokyo Institute of Technology Bioscience and Biotechnology
  • - 1994 Tokyo Institute of Technology School of Bioscience and Biotechnology
Professional career (1)：
  • Doctor of Engineering
Work history (9)：
  • 2022/04 - 現在 Japan Synchrotron Radiation Research Institute Structural Biology Division Research Scientist
  • 2018/02 - 2022/03 RIKEN SPring-8 Center Research Scientist
  • 2014/09 - 2018/01 RIKEN Center for Life Science Technologies Senior Scientist
  • 2010/01 - 2014/08 Yale University School of Medicine Department of Cellular and Molecular Phisiology associate research scientist
  • 2003/05 - 2004/12 Tokyo Institute of Technology Graduate School of Biological Science and Technology Assistant Professor
Show all
Association Membership(s) (5)：
THE JAPANESE SOCIETY OF MICROSCOPY ,  日本化学会 ,  The Japanese Biochemical Society ,  The Protein Society of Japan ,  The Chemical Society of Japan
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