Atsushi Kasai

カサイアツシ | Atsushi Kasai

Affiliation and department：
Job title： Professor
Homepage URL (2)： http://molpharm.umin.jp/ , http://envyscience.umin.jp/

Research field (3)： Neuroscience - general , Pharmacology , Pharmaceuticals - health and biochemistry

Research keywords (8)：発達障害 , anxiety , stress , claustrum , 脳情報動態 , マルチスケール脳 , imaging , psychiatric disorder

Research theme for competitive and other funds (28)：

2022 - 2025 The science of envy: Bio-Robotics integration for understanding social emotions and achieving an inclusive society
2022 - 2025 嫉妬の科学推進のための戦略的研究推進支援
2022 - 2025 げっ歯類の嫉妬:全脳活動計測による嫉妬の生成モジュールの探索
2021 - 2025 Mechanism of drug addiction based on multi-scale analysis
2022 - 2024 レジリエンスを獲得させる新たなストレス関連障害治療戦略

2021 - 2024 Mechanisms of neurodevelopmental disorders

2021 - 2024 Identity and circuit functions of glia engrams

2021 - 2023 マルチスケール解析によるストレス性精神疾患の構成的理解

2020 - 2023 脳疾患の解明と創薬へ向けた疾患モデル脳のマルチスケールデータ解析

2020 - 2023 全脳細胞解析による不安制御に関わる神経基盤の解明と創薬研究への応用

2020 - 2022 多階層オミックス解析による発達障害の発症機序の解明

2020 - 2022 負の情動行動を制御する脳領域間情報動態の解明

2020 - 2022 中枢疾患創薬を加速する全脳細胞解析による不安障害の標的分子の探索

2019 - 2021 トランスオミックス解析によるストレス性精神疾患の構成的理解

2019 - 2021 母体免疫活性と胎仔脳の相互作用に起因する社会性行動の異常に関わる全脳活動変化と分子基盤の解明

2018 - 2020 Development of a single-cell RNA sequencing method linked to spatio-temporal cellular characteristics

2018 - 2020 高精細全脳イメージングを用いた負の情動行動制御における多領野連関解析

2017 - 2020 A novel mechanism for the development of stress-related psychiatric disorders

2018 - 脳機能解明に資する細胞種特異的な多色蛍光標識マウスの開発

2015 - 2017 Whole brain activity mapping and analysis of neuronal innervation in a stress model

2013 - 2016 Functional analyses of mitochondrial fusion inhibition in the regulation of neuronal cells

2013 - 2015 Neural stem cells have directivity characteristics in the cell fate decision.

2010 - 2012 Involvement of Apelin/APJ system in intraocular neovascularizatio

2009 - 2011 Research on the onset and progression of amyotrophic lateral sclerosis using genetically modified animals

2009 - 2010 Possibility of apelin in ischemic retinal disease as a new target for drug development

2008 - 2010 筋萎縮性側索硬化症モデルマウスを用いた新規創薬標的分子の探索

2009 - 2009 オーファンGPCRリガンドapelinの神経保護作用に関する神経薬理学的研究

2007 - 2008 Involvement of apelin, an endogenous ligand for GPCR APJ, in the development of ischemic retinopathy

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Papers (74)：

Rei Yokoyama, Yukio Ago, Hisato Igarashi, Momoko Higuchi, Masato Tanuma, Yuto Shimazaki, Takafumi Kawai, Kaoru Seiriki, Misuzu Hayashida, Shun Yamaguchi, et al. (R)-ketamine restores anterior insular cortex activity and cognitive deficits in social isolation-reared mice. Molecular psychiatry. 2024
Rei Yokoyama, Momoko Higuchi, Wataru Tanabe, Shinji Tsukada, Hisato Igarashi, Kaoru Seiriki, Takanobu Nakazawa, Atsushi Kasai, Yukio Ago, Hitoshi Hashimoto. Long-lasting anti-despair and anti-anhedonia effects of (S)-norketamine in social isolation-reared mice. Journal of pharmacological sciences. 2024. 154. 2. 72-76
Yumi Hirato, Kaoru Seiriki, Leo Kojima, Shohei Yamada, Hiroki Rokujo, Tomoya Takemoto, Takanobu Nakazawa, Atsushi Kasai, Hitoshi Hashimoto. Clozapine Induces Neuronal Activation in the Medial Prefrontal Cortex in a Projection Target-Biased Manner. Biological & pharmaceutical bulletin. 2024. 47. 2. 478-485
Masakazu Agetsuma, Issei Sato, Yasuhiro R Tanaka, Luis Carrillo-Reid, Atsushi Kasai, Atsushi Noritake, Yoshiyuki Arai, Miki Yoshitomo, Takashi Inagaki, Hiroshi Yukawa, et al. Activity-dependent organization of prefrontal hub-networks for associative learning and signal transformation. Nature communications. 2023. 14. 1. 5996-5996
Yuma Nagai, Yuri Kisaka, Kento Nomura, Naoya Nishitani, Chihiro Andoh, Masashi Koda, Hiroyuki Kawai, Kaoru Seiriki, Kazuki Nagayasu, Atsushi Kasai, et al. Dorsal raphe serotonergic neurons preferentially reactivate dorsal dentate gyrus cell ensembles associated with positive experience. Cell Reports. 2023. 42. 3. 112149-112149

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MISC (55)：

Taro Ichimura, Taishi Kakizuka, Kazuki Horikawa, Kaoru Seiriki, Atsushi Kasai, Hitoshi Hashimoto, Katsumasa Fujita, Tomonobu M. Watanabe, Takeharu Nagai. Trans-scale-scope to find rare cellular activity in sub-million cells. 2020
勢力薫, 笠井淳司, 丹生光咲, 田沼将人, 五十嵐久人, 中澤敬信, 山口瞬, 井上謙一, 高田昌彦, 橋本均. 高精細全脳イメージング技術FASTの開発と精神疾患モデルマウスの病態解析 -脳全体を対象とした仮説フリーな病態・薬物治療機序の組織学的解析-. 第68回日本薬学会近畿支部総会・大会. 2018
Hashimoto H, Seiriki K, Kasai A, Nakazawa T, Inoue K, Takada M. High-resolution imaging of primate brains using FAST. International Workshop "Monitoring and manipulating brain function in non-human primates"(2018/7/31, 千葉市). 2018
Kaoru Seiriki, Atsushi Kasai, Hitoshi Hashimoto. Whole-brain imaging analysis of animal models of neuropsychiatric disorders. Japanese Journal of Biological Psychiatry. 2018. 29. 1. 22-26
Kasai A, Seiriki K, Hashimoto T, Niu M, Yamaguchi S, Naka Y, Igarashi H, Tamura M, Nakazawa T, Inoue K, et al. FAST, High-speed serial-sectioning imaging for whole brain analysis with high scalability. Neuroscience 2017(2017/11/13,Washington, DC, USA). 2017

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Lectures and oral presentations (23)：

サポートベクターマシーンを用いたストレス応答制御機構の解明
(第2回脳科学サロン「脳とAI」 2020)
脳機能解明に向けた全脳多色蛍光標識法の開発
(第67回日本実験動物学会総会 2020)
3次元定量的脳形態計測システムの構築:マイクロエンドフェノタイプの探索へ
(マイクロ精神病態班会議 2014)
血管新生性眼疾患とアペリン-APJシステム~創薬標的分子としての可能性~
(日本薬学会第134年会 2014)
精神疾患の発症に関わる遺伝子x環境相互作用ダイナミクスの解析系の構築
(FISRT EXPO 2014 2014)

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Education (3)：

2004 - 2007 Osaka University Graduate School of Pharmaceutical Sciences
2002 - 2004 Osaka University Graduate School of Pharmaceutical Sciences
1997 - 2002 University of Shizuoka School of Pharmaceutical Sciences

Professional career (1)：

Ph.D.(Pharmaceutical Sciences) (Osaka University)

Work history (7)：

2024/04 - 現在 Nagoya University Research Institute of Environmental Medicine Professor
2020/06 - 2024/03 Osaka University Associate Professor
2020/04 - 2020/06 Osaka University Junior Associate Professor
2014/09 - 2020/03 Osaka University Graduate School of Pharmaceutical Sciences
2012/05 - 2014/09 Osaka University Institute for Academic Initiatives

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Committee career (2)：

2012 - 現在 The Japanese Pharmacological Society Fellow
2019/05 - The Japanese Society for Neurochemistry Publicity Commitee

Awards (8)：

2022/08 - 日本薬学会令和3年度日本薬学会薬理系薬学部会奨励賞
2022/07 - Japanese Society for Neurochemistry The Award for Distinguished Investigator of Japanese Society for Neurochemistry
2020/01 - 武田科学振興財団第10回武田科学振興財団薬科学シンポジウム Excellent Poster Award
2014/12 - Comprehensive Brain Science Network Young Investigator's Award
2014/07 - 大阪大学大阪大学総長奨励賞

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Association Membership(s) (5)：

Society for Neuroscience , Japanese Society of Neuropsychopharmacology , THE JAPANESE SOCIETY FOR NEUROCHEMISTRY , THE PHARMACEUTICAL SOCIETY OF JAPAN , THE JAPANESE PHARMACOLOGICAL SOCIETY

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