2020 - 2023 Effect of rehabilitation on the white matter and evaluation of motor function using 3D motor analysis in the rat model of cerebral infarction.
2019 - 2022 Development of a prediction system of systemic disease using AI technology based on oral flora.
2017 - 2021 The role of exercise on the oligodendrogenesis and recovery of motor functions in focal stroke model in rats
2016 - 2019 Investigation of mechanisms of rapture in cerebral aneurysm and research of its biomakers
2015 - 2017 The role of the exercise related lactate on the corticospinal reorganization in the focal stroke rat.
2014 - 2017 The roles of exercises on motor recovery and neuronal reorganization reltated with GABA systems in the focal motor stroke rats
2013 - 2016 Development of PET probes of neuroprotective molecular components in oriental medicines
2013 - 2016 Role of exercises on reorganization of the neuronal tissues in the experimental brain infarction
2012 - 2015 Relevance of oral bacteria and ruptured cerebral aneurysm
2012 - 2015 Investigation of mechanisms of cerebral hemorrhage by S. mutans and search of biomarkers
2011 - 2014 Investigation of mechanism of systemic diseases caused by oral bacteria and development of preventive procedures
2011 - 2013 Development of genomics-based prophylaxis strategy for gastric mucosal injury induced by anti-platelet agents
2011 - 2012 The role of ADP receptor (P2Y12) in the development of transplant arteriosclerosis
2010 - 2012 Effects of exercises on neurogenesis and angiogenesis in the experimental brain infarction
2009 - 2011 Elucidation of mechanism for development of cerebrovascular diseases associated with oral bacteria and pursuit of preventive approach
2008 - 2010 Mechanisms of stroke progression by periodontal bacteria
2003 - 2005 Pharmacological investigation for mechanisms of cerebral hemorrhage induced by anti-thrombotic agents
2001 - 2002 Significance of vascular hormones in vasculoangiogenesis and vascular endocrinological approach to organ protection and regeneration
2000 - 2002 Pharmacological investigation of roles of cyclic flow reductions in the development of cerebral infarction
1998 - 1999 Elucidation of role of vascular local hormones on endothelial differentiation by developmental cell bilology and its application to vascular regeneration therapy.
1995 - 1996 Special Stenting System with blood flow control and prevention of intimal hyperplasia using Angiotensin converting enzyme inhibitor
医薬品開発(臨床第1相試験)
脳保護剤の開発
非臨床試験からヒトへの予測
脳虚血障害のメカニズム解明
Estimation to human of non-clinical studies
Evaluation of effect of drug on cerebrol thrombosis
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Papers (188)：
Hirokazu Nakatogawa, Kazuya Hokamura, Ryota Nomura, Kazuhiko Nakano, Kazuo Umemura, Akio Morita, Yoichiro Homma, Tokutaro Tanaka. Is oral Streptococcus mutans with collagen-binding protein a risk factor for intracranial aneurysm rupture or formation?. Cerebrovascular diseases (Basel, Switzerland). 2024
Masamitsu Takaba, Takayuki Iwaki, Tomohiro Arakawa, Takaaki Ono, Yuichiro Maekawa, Kazuo Umemura. Dasatinib suppresses atherosclerotic lesions by suppressing cholesterol uptake in a mouse model of hypercholesterolemia. Journal of pharmacological sciences. 2022. 149. 3. 158-165
Takayuki Iwaki, Yuki Tomonari, Kazuo Umemura. Successful lactation in Plgrkt-deficient female mice caused by a 1-bp deletion of exon4. The Journal of dairy research. 2022. 1-4
