Rchr
J-GLOBAL ID：200901031092970257
Update date: Jan. 31, 2024
Tomoo Koji
トモオ コウジ | Tomoo Koji
Affiliation and department：
Research field (1)：
Pharmaceuticals - analytical and physicochemistry
Research keywords (2)：
タンパク質結晶学
, Protein Crystallography
Research theme for competitive and other funds (24)：
- 2023 - 2026 腸炎ビブリオのシデロフォア生合成酵素の機能解明:新規細菌増殖抑制剤の開発に向けて
- 2011 - 2012 Development of the virus vaccine by the elucidation of the virulence of a plant virus
- 2010 - 2012 Discovery of novel anti-cancer drug :The search for regulatory elements of eukaryotic initiation factor 4E.
- 2011 - 2011 タウ重合に必須なCH-π相互作用阻害剤の開発:認知症治療薬開発の基盤研究
- 2009 - 2011 Studies of structure-function relationship and self-aggregation mechanism of tau protein for development of the therapeutic drug of Alzheimer's disease.
- 2008 - 2010 Development of the inhibitor for tangle formation of tau protein : Basic research for prevention of Altzheimer disease
- 2008 - 2010 Interaction between Potyvirus viral protein linked to the genome and host cell protein
- 2006 - 2007 Discovery of novel anti-cancer drug : Elucidation of the regulatory function of endogenous 4E-binding protein for eukaryotic initiation factor 4E
- 2006 - 2007 Studies on roles of potyviral protein on plant viral disease
- 2005 - 2007 Elucidation of Self-aggregation Mechanism of Tau Protein : Basic Research for Drug Development of Inhibiting Alzheimer's disease
- 2004 - 2005 Studies on interaction between potyvirus VPg and plant eIF(iso)4E
- 2001 - 2003 Elucidatiop of Tangle Formation Mechanism Based on 3D-structural Analysis of Tau Protein
- 1998 - 1998 ホスホリパーゼA_2の構造化学的研究と特異的阻害剤の開発
- 1995 - 1997 Interaction between heteromolecules-Structural study and application of PNA-
- 1996 - 1996 ホスホリパーゼA_2の構造化学的研究と特異的阻害剤の分子設計
- 1994 - 1996 Molecular design of cathepsin L-specific inhibitor based on the teritiary structure.
- 1995 - 1995 ホスホリパーゼA_2の構造化学的研究と特異的阻害剤の開発
- 微小管結合蛋白質tauの異常凝集機構の解明
- 蛋白質生合成開始因子4Eの構造化学的研究
- チオールプロテアーゼの構造化学的研究
- Stractural study of eIF-4E
- Structural study of SH-Protease
- Structural study of Phospholipase A2
- 病原性微生物の膜輸送機構の構造化学的研究と新規抗菌薬の開発
Show all
Papers (102)：
-
Tomotaka Tanabe, Hidemichi Mitome, Katsushiro Miyamoto, Kazuki Akira, Hiroshi Tsujibo, Koji Tomoo, Kenjiro Nagaoka, Tatsuya Funahashi. Analysis of the vibrioferrin biosynthetic pathway of Vibrio parahaemolyticus. Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine. 2023
-
Tomohiro Tsuchida, Kouki Susa, Tomohiro Kibiki, Takahiro Tsuchiya, Katsushiro Miyamoto, Yasuko In, Katsuhiko Minoura, Taizo Taniguchi, Toshimasa Ishida, Koji Tomoo. Structural study of the recognition mechanism of tau antibody Tau2r3 with the key sequence (VQIINK) in tau aggregation. Biochemical and biophysical research communications. 2021. 585. 36-41
-
Katsushiro Miyamoto, Hiroaki Kawano, Naoko Okai, Takeshi Hiromoto, Nao Miyano, Koji Tomoo, Takahiro Tsuchiya, Jun Komano, Tomotaka Tanabe, Tatsuya Funahashi, et al. Iron-Utilization System in Vibrio vulnificus M2799. Marine Drugs. 2021. 19. 12. 710-710
-
Naoko Okai, Katsushiro Miyamoto, Koji Tomoo, Takahiro Tsuchiya, Jun Komano, Tomotaka Tanabe, Tatsuya Funahashi, Hiroshi Tsujibo. VuuB and IutB reduce ferric-vulnibactin in Vibrio vulnificus M2799. Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine. 2020. 33. 4-5. 187-200
-
Tomohiro Tsuchida, Kouki Susa, Tomohiro Kibiki, Takahiro Tsuchiya, Katsushiro Miyamoto, Yasuko In, Katsuhiko Minoura, Taizo Taniguchi, Toshimasa Ishida, Koji Tomoo. Crystal structure of the human tau PHF core domain VQIINK complexed with the Fab domain of monoclonal antibody Tau2r3. FEBS letters. 2020
ｍore...
MISC (28)：
-
菊地崇, 堀井祐衣, 前川由季菜, 桝本有季, 尹康子, 友尾幸司, 佐藤寛泰, 山野昭人, 山田剛司, 田中麗子. エリンギ(Pleurotus eryngii)子実体のステロイド-Pleurocin AおよびBの構造と一酸化窒素産生抑制活性-. 日本生薬学会年会講演要旨集. 2017. 64th
-
友尾幸司, 澤田怜, 田宮祥恵, 二神康介, 山田剛司, 箕浦克彦, 尹康子, 中村達也, 吾妻正章, 谷口泰造. 和歌山県産山椒果皮由来成分におけるアルツハイマー型認知症関連タンパク質tauの凝集阻害効果について. 日本薬学会年会要旨集(CD-ROM). 2017. 137th
-
菊地崇, 桝本有季, 尹康子, 友尾幸司, 山田剛司, 田中麗子. エリンギ(Pleurotus eryngii)子実体に含まれる新規ergostane型ステロイド. 日本生薬学会年会講演要旨集. 2015. 62nd
-
SOGAWA Koushirou, OKUDA Ryouhei, MINOURA Katsuhiko, IN Yasuko, ISHIDA Toshimasa, TANIGUCHI Taizo, TOMOO Koji. CH-π Interaction between I308 and Y310 Residues is Required for Self Assembly of Full Length Tau. Peptide science : proceedings of the ... Japanese Peptide Symposium. 2012. 2011. 165-168
-
MINOURA Katsuhiko, NARUTO Keiko, OKUDA Ryouhei, TANIGUCHI Taizo, IN Yasuko, ISHIDA Toshimasa, TOMOO Koji. Importance of CH-π Interaction Between I308 and Y310 Residues in the Third Repeat of Microtubule Binding Domain for Tau Filament Formation. Peptide science : proceedings of the ... Japanese Peptide Symposium. 2011. 2010. 166-166
ｍore...
Books (1)：
-
ベーシック薬学教科書シリーズ 物理化学(第2版)
化学同人 2018
Lectures and oral presentations (94)：
-
アルツハイマー型認知症関連タンパク質Tauの特異的認識抗体による,Tau自己凝集阻害機構の解明
(日本薬学会年会要旨集(CD-ROM) 2018)
-
エリンギ(Pleurotus eryngii)子実体のステロイド-Pleurocin AおよびBの構造と一酸化窒素産生抑制活性-
(日本生薬学会年会講演要旨集 2017)
-
好熱性放線菌Streptomyces thermoviolaceus OPC-520株由来糖結合タンパク質BxlEの糖結合機構の解明
(日本薬学会年会要旨集(CD-ROM) 2017)
-
和歌山県産山椒果皮由来成分におけるアルツハイマー型認知症関連タンパク質tauの凝集阻害効果について
(日本薬学会年会要旨集(CD-ROM) 2017)
-
臨床分離株Vibrio vulnificus M2799由来シデロフォア結合タンパク質VatDとシデロフォアとの相互作用解析
(日本薬学会年会要旨集(CD-ROM) 2016)
ｍore...
Education (4)：
- - 1992 Osaka University of Pharmaceutical Sciences Graduate School of Pharmaceutical Sciences
- - 1992 Osaka University of Pharmaceutical Sciences Graduate School, Division of Pharmaceutical Sciences
- - 1987 Osaka University of Pharmaceutical Sciences Faculty of Pharmaceutical Sciences Department of Pharmacy
- - 1987 Osaka University of Pharmaceutical Sciences Faculty of Pharmaceutical Science
Professional career (2)：
- (BLANK) (Osaka University of Pharmaceutical Sciences)
- (BLANK) (Osaka University of Pharmaceutical Sciences)
Work history (1)：
- 1997/10 - 1998/12 ベルリン自由大学結晶学研究所博士研究員
Awards (1)：
Association Membership(s) (3)：
Return to Previous Page
