Ohara Osamu

2018 - 2021 Multi-OMICS approaches to investigate molecular pathogenesis of primary immune deficiency

2017 - 2019 Roles of TET family in dynamic epigenomic alteration induced by EB virus infection

2016 - 2019 Investigation of molecular mechanism and therapeutic target of Chronic Mucocutaneous Candidiasis

2016 - 2019 Elucidating the mechanism of NLRP3 inflammasome activation using fluorescence and light emission protein-interaction sensors

2015 - 2018 Exploration of the causative genes and elucidation of the pathophysiology on immune dysregulatory diseases with intractable inflammation

2015 - 2018 Development of personalized lung cancer vaccine targeting neoantigens

2015 - 2018 Function of APOBEC3 in EBV-positive T or NK-cell lymphoproliferative diseases

2014 - 2017 Establishing a platform for molecular analysis and drug innovation of auto-inflammatory disorders

2014 - 2017 Elucidation of molecular mechanism of cytopenia associated with immunodeficiency/immune disorder

2014 - 2017 Establishment of novel diagnosis and analysis of pathogenesis of herediatry lymphoproliferative disorders

2014 - 2017 Establishing an innovative platform for the analysis of hemophagocytic lymphohistiocytosis

2014 - 2016 Investigation of pathology and development of specific medial care system and treatment associated with FLNA deficiency

2013 - 2016 Elucidation of cold-induced gene induction mechanism by analyzing Mendelian-inherited diseases with cold-induced inflammation

2013 - 2015 The study to clarify the molecular mechanism of fate decision of activated CD4 T cells

2013 - 2015 Establishment of mouse model of chronic mucocutaneous candidiasis disease and use them to find therapeutic target

2012 - 2015 Exploration of the responsible gene and the pathophysiology for unidentified fever syndromes by whole genome analysis and cell-based engineering

2011 - 2014 Analysis and development of medical treatment for autoinflammatory diseases

2011 - 2014 Research on molecular mechanisms of break in immunological tolerance in disorders caused by single-gene defect

2011 - 2014 Molecular mechanism on granuloma formation based on the analysis with cellular and molecular biology

2011 - 2012 A study to establish system to evaluate diversities of cell populations of melanoma

2010 - 2012 Research for developing of a screening method for the congenital immunodeficiency by KREC/TREC to apply the method to the pathologic analysis

2009 - 2011 Development of CINCA syndrome therapy based upon the pathophysiology of CINCA syndrome elucidated by cytoengineering.

2009 - 2011 Comprehensive analysis of splicing variants characteristic of acute myelogenous leukemia stem cells

2009 - 2010 遺伝子制御ネットワークの動的挙動の解明:制御論的理論解析と実験による検証

2009 - 2010 Development of easy and cost-effective mass-screening of severe combined immunodeficiency using neonatal guthrie cards.

2004 - 2006 Memory B cell commitment, maintenance and terminal differentiation

2001 - 2002 ヒト脳内長鎖cDNA解析データベースを基盤としたマウス扁桃体の情動神経機構の解明

1992 - 1994 Studies on neurofilament-deficient quails-an animal model for neuropathology

1994 - 免疫ゲノミクス

Immunogenomics