Nishijima Ken'ichi

Research field (2)： Applied molecular and cellular biology , Applied biofunctional and bioprocess engineering

Research keywords (7)：インフルエンザ , CHO , 始原生殖細胞 , シアル酸 , 炎症 , 糖鎖制御 , トランスジェニックニワトリ

Research theme for competitive and other funds (35)：

2022 - 2026 Elucidation of the genetic basis for the temperament of chickens and identification of the causal genes
2021 - 2024 デザイン型育種プロセスの創成とインフルエンザ抵抗性ニワトリ作製への展開
2020 - 2024 ゲノム編集ニワトリによる高機能インフルエンザワクチンの生産
2020 - 2024 Development of integrated animal cell engineering system for biopharmaceutical production
2017 - 2022 Integrated platform for mammalian cell-based cell and bioprocess engineering

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Papers (75)：

Yusuke Kojima, Yuya Okuzaki, Ken-Ichi Nishijima, Shuichiro Moriwaki, Seiya Asai, Hidenori Kaneoka, Shinji Iijima. Regulatory mechanism of chicken lysozyme gene expression in oviducts examined using transgenic technology. Journal of bioscience and bioengineering. 2021. 131. 4. 453-459
Yota Hagihara, Yuya Okuzaki, Kazuma Matsubayashi, Hidenori Kaneoka, Takayuki Suzuki, Shinji Iijima, Ken-Ichi Nishijima. Primordial germ cell-specific expression of eGFP in transgenic chickens. Genesis (New York, N.Y. : 2000). 2020. 58. 8. e23388
Tateyama, Hiroyuki, Murase, Yusuke, Higuchi, Hiroshi, Inasaka, Yui, Kaneoka, Hidenori, Iijima, Shinji, Nishijima, Ken-ichi. Siglec-F is induced by GM-CSF and enhances IL-4-induced expression of arginase-1 in mouse macrophages. Immunology. 2019. 158. 340-352
Tsujino K, Okuzaki Y, Hibino N, Kawamura K, Saito S, Ozaki Y, Ishishita S, Kuroiwa A, Iijima S, Matsuda Y, et al. Identification of transgene integration site and anatomical properties of fluorescence intensity in a EGFP transgenic chicken line. Dev Growth Differ. 2019. doi: 10.1111/dgd.12631
Okuzaki, Y, Kaneoka, H, Suzuki, T, Hagihara, Y, Nakayama, Y, Murakami, S, Murase, Y, Kuroiwa, A, Iijima, S, Nishijima, K. PRDM14 and BLIMP1 control the development of chicken primordial germ cells. Developmental Biology. 2019. 455. 1. 32-41

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MISC (43)：

Iijima S., Kaneoka H., NISHIJIMA K. Genetically Manipulated Chickens as Animal Bioreactor. In Vitro Cellular & Developmental Biology - Animal. 2016. 52. 1. s11-s12
Moriwaki Shuichiro, Kojima Yusuke, Okuzaki Yuya, Asai Seiya, Kaneoka Hidenori, Nishijima Ken-ichi, Iijima Shinji. 3P-239 Oviduct-specific expression of therapeutic protein utilizing chicken lysozyme promoter. 2015. 67. 330-330
Kidani Shunsuke, Okuzaki Yuya, Kaneoka Hidenori, Nishijima Ken-ichi, Iijima Shinji. 3P-240 Functional analysis of chicken IFITM. 2015. 67. 330-330
Kojima Yusuke, Kidani Shunsuke, Kaneoka Hidenori, Nishijima Ken-ichi, Iijima Shinji. 3P-241 Analyses of chicken sialyltransferases. 2015. 67. 331-331
Nishijima Ken-ichi, Mori Komei, Kamihira Masamichi, Iijima Shinji. 2P-252 Genetic locus supporting high expression of transgene in CHO cells. 2015. 67. 237-237

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Patents (5)：

Books (12)：

糖鎖から見たインフルエンザの適応変異
学会出版センター 2019
動物細胞が培養可能になった頃
日本生物工学会 2016
生殖工学とトランスジェニック動物
丸善出版 2014
タンパク質の次は糖鎖の時代になるの?
化学同人 2012
遺伝子組換え鳥類の作製と抗体生産技術
CMC出版 2012

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Lectures and oral presentations (4)：

Generically Manipulated Chickens as Animal Bioreactor
(World Congress on In Vitro Biology 2016)
Toward the understanding of transgenesis property of chicken PGCs
(International Forum on Avian Germplasm 2013)
Siglec-9 inhibits innate immunity
(Sialoglycoscience 2006 2006)
Production of Antibody by Transgenic Chicken
(World Congress on In Vitro Biology 2004)

Professional career (1)：

博士(農学) (東京大学)

Work history (1)：

2020/04 - Nagoya University Graduate School of Bioagricultural Sciences, Avian Bioscience Research Center

Committee career (8)：

2017/07 - 現在日本糖質学会評議員
2015/04 - 現在 Cytotechnology Consulting Editor
2011/06 - 現在日本動物細胞工学会庶務幹事
2011/06 - 現在日本生物工学会中部支部幹事
2007/04 - 現在日本動物細胞工学会幹事

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Awards (5)：

2018 - 日本農芸化学会 2018年度大会トピックス賞培養始原生殖細胞の樹立とCRISPR/Cas9によるeGFPノックインニワトリの作製
2014 - Wiley Blackwell Wiley Blackwell Prize 2014 Transgenic chicken
2009 - 日本生物工学会第17回生物工学論文賞 Production of Recombinant Tumor Necrosis Factor Receptor/Fc Fusion Protein by Genetically Manipulated Chickens
2007 - 日本生物工学会第15回生物工学論文賞 Production of scFv-Fc fusion protein using genetically manipulated quails
2005 - 日本動物細胞工学会奨励賞動物細胞機能の有効利用に関する細胞工学的研究

Association Membership(s) (4)：

THE JAPANESE SOCIETY OF CARBOHYDRATE RESEARCH , JAPAN SOCIETY FOR BIOSCIENCE, BIOTECHNOLOGY, AND AGROCHEMISTRY , The Society for Biotechnology, Japan , JAPANESE ASSOCIATION FOR ANIMAL CELL TECHNOLOGY

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