Rchr

J-GLOBAL ID：200901031483290390 Update date: Jan. 31, 2024

Hatano Masahiko

Homepage URL (2)： http://www.m.chiba-u.ac.jp/class/biomedical/ , http://devgen01.m.chiba-u.ac.jp/

Research field (1)： Pathobiochemistry

Research keywords (2)：転写因子 Transcriptionfactor アポトーシス Apoptosis 癌遺伝子 Oncogene , Transcriptionfactor Apoptosis Oncogene

Research theme for competitive and other funds (82)：

2022 - 2025 腸管神経系による好酸球制御機構とその破綻による腸炎等発症機構解析
2021 - 2024 Treatment strategy against sepsis induced thrombocytopenia and the associated complement hyperactivation
2020 - 2023 腸管神経系と免疫系の相互作用による全身性エリテマトーデスの病態制御機構の解明
2018 - 2023 Role of Autophagy in the Cellular Immunity of Biliary Atresia
2019 - 2022 Elucidation of pathological control mechanism of rheumatoid arthritis by interaction between enteric nervous system and immune system and development of novel treatment

2018 - 2022 Crosstalk between enteric neurons, immune cells and intestinal flora in the maintenance of intestinal homeostasis

2018 - 2021 New therapeutic strategy for multiple sclerosis modifying pathogenetic T cell differentiation

2018 - 2021 The kinetics of autophagy following septic insults from metabolomics analyses - Exploration of novel biomarkers on sepsis -

2018 - 2021 Development of therapeutic strategy based on the functional regulation of TFH cells for systemic lupus erythematodes

2017 - 2020 Elucidation of molecular mechanism of specific immune memory and development of therapeutic strategy for autoimmune diseases

2016 - 2020 A regulatory role of the double-stranded RNA editing enzyme ADAR1 for adaptive immune response

2016 - 2018 Development of approaches to control vascular permeability using mouse models with increased vascular permeability

2015 - 2018 Frequency and function of regulatory T cell subpopulation of biliary atresia

2015 - 2018 Development of a novel method for therapy against autoimmune disease

2015 - 2017 腸管神経による免疫系・上皮系バリアおよび腸内フローラ制御機構解析

2015 - 2017 Investigating relationship between apoptosis of intestinal epithelial cells and sepsis using Ncx KO mice.

2015 - 2017 A potential role of autophagy in immune cells during sepsis

2013 - 2016 Role of enteric neurons in regulation of intestinal inflammation

2013 - 2016 Maintenance of intestinal homeostasis by enteric neuron and mucosal immune system

2013 - 2016 Aromatase induces ovulation via a reduction of follicular androgen and its application for infertility treatment

2012 - 2015 Numerical and Functional Analyses of Regulatory T Cells in Biliary Atresia.

2011 - 2012 Molecular mechanism of alveolar formation

2008 - 2010 Role of BCL6 a transcriptional repressor in the pathogenesis of chronic pulmonary inflammatory disease.

2008 - 2010 Mechanism of memory CD8 T cell generation

2008 - 2010 Molecular mechanism of neural crest cell proliferation, differentiation and death

2008 - 2010 Survival mechanism of memory B cells

2007 - 2008 Study on a new assay for the function of mammalian spenn centrosome

2006 - 2007 気管支喘息における新規のTh2細胞維持機構の解明と新規治療の研究開発

2006 - 2007 細胞寿命に関する転写因子レベルでの研究

2006 - 2007 Role of Bcl6 for generation of CD8+ dendritic cells

2006 - 2007 Regulation of neural crest cell proliferation, differentiation and death in normal development and diseases

2006 - 2007 A role of Bcl6 in regulation of somatic hypermutation in the immunoglobulin gene

2006 - 2007 グリア-ニューロン間におけるD型セリンの分子機構解明

2004 - 2006 Regulation for expression of chemokine genes in the gene cluster including CCL2/MCP-1 by BCL-6

2004 - 2005 A role of Bc16 in differentiation of dendritic cells

2004 - 2005 消化器癌の浸潤・転移制御を行うkelch関連遺伝子を用いた新しい遺伝子治療の開発

2004 - 2005 Molecular mechanism of neural crest cell differentiation, proliferation and death

2004 - 2005 A role of Bcl6 in induction of somatic hypermutation in immunoglobulin gene

2004 - 2005 グリア-ニューロン間におけるD型セリンの分子機構解明

2004 - 2004 新規アクチン結合蛋白Nd1による細胞骨格制御と発癌

2003 - 2004 Cystogenesis in the gene targeting mice of autosomal dominant polycystic kidney disease (ADPKD)

2003 - 2003 新規アクチン結合蛋白Nd1による細胞骨格制御と発癌

2003 - 2003 BCL6がん遺伝子のリンパ球腫瘍化機序の解析

2003 - 2003 免疫記憶の成立機構に関する転写因子レベルでの解析

2002 - 2003 Functional analysis of BCL6 on allergic inflammation

2002 - 2003 Induction Mechanisms of Memory T Cells

2002 - 2003 IAPファミリー蛋白TIAP/Survivinによる細胞死、細胞周期の制御と発癌

2002 - 2002 TIAP/Survivinによる細胞死、細胞周期の制御と発癌機構の解析

2001 - 2002 新規アクチン結合蛋白ND-1の機能と心疾患病態解析への応用

2001 - 2002 Control of hematopoietic cell differentiation by c-Fos and Bcl6

2001 - 2002 TIAP/Survivinによる細胞死,細胞周期の制御と発癌機構

2001 - 2002 IAPファミリー蛋白TIAP/survivinによる細胞死,細胞周期の制御と発癌

2001 - 2002 B細胞の抗体産生とアポトーシスを制御する新規遺伝子in vivoにおける機能

2000 - 2001 好酸球性炎症の抑性機序の解析

2000 - 2001 Development of the gene therapy model for allergic diseases

2000 - 2001 Molecular genetics of neurocristopathy

2000 - 2000 新しいIAPファミリー蛋白TIAPによる細胞死、細胞周期の制御機構解析

2000 - 2000 BCL6の強発現によるリンパ球腫瘍化能の解析

2000 - 2000 AP-1遺伝子群による造血制御

1999 - 2000 Control of Hematopoiesis by AP-1 and Bcl6

1999 - 2000 Induction mechanisms of B cell self-toleranace

1999 - 1999 終末分化した心筋細胞の機能維持機構の解析

1999 - 1999 転写抑制因子(BCL6遺伝子群とポリコーム遺伝子群)による造血制御

1999 - 1999 新しいIAPファミリー蛋白TIAPによる細胞死、細胞周期の制御機構解析

1998 - 1999 Analysis of NCX gene mutation in patients with Hirschsprung-related disease

1998 - 1999 DEVELOPMENT OF ANIMAL MODEL OF DILATED CARDIOMYORATHY

1998 - 1998 BCL6ファミリーによる終末分化細胞死の抑制機序の解析

1997 - 1998 FUNCTIONAR ROFE OF C-FOS IN DIFFERENTIATION AND PROLIFERATION OF MATURE B CELLS

1997 - 1997 Ncxノックアウトマウスにおける巨大結腸症と神経細胞死

1997 - 1997 BCL6欠損マウスに見られた終末分化細胞死の誘導機序の解析

1996 - 1996 B細胞初期分化におけるc-FosやBCL6遺伝子の機能解析

1996 - 1996 メモリーB細胞分化の分子機構の解析

1996 - 1996 c-Fosによるアポトーシス誘導機序の解析

1995 - 1995 B細胞初期分化増殖におけるC-Fosがん遺伝子の機能解析

1995 - 1995 HOX11によるリンパ球腫瘍化の分子機構の解析

1995 - 1995 B細胞免疫寛容とメモリーB細胞分化の分子機構の解析

1994 - 1994 AP-1のB細胞初期分化における機能解析

1994 - 1994 T細胞アポプトーシスにおけるHOX11の役割の解析

1994 - 1994 HOX11によるリンパ球腫瘍化の分子機構の解析

1994 - 1994 B細胞免疫寛容とメモリーB細胞分化の分子機構の解析

1993 - 1993 AP-1のB細胞分化における機能解析

1993 - 1993 リンパ球増殖におけるc-fosがん遺伝子産物の機能解析

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Papers (122)：

Miruto Tanaka, Shinsuke Nakamura, Tomohisa Sakaue, Takumi Yamamoto, Masashi Maekawa, Anri Nishinaka, Hiroto Yasuda, Kaori Yunoki, Yuji Sato, Masaaki Sawa, et al. BCL6B Contributes to Ocular Vascular Diseases via Notch Signal Silencing. Arteriosclerosis, thrombosis, and vascular biology. 2023. 43. 6. 927-942
Satoru Oita, Takeshi Saito, Akemi Sakamoto, Lisa Fujimura, Yukiko Ohara, Takashi Fumita, Keita Terui, Mitsuyuki Nakata, Shugo Komatsu, Gen Matsuura, et al. Frequency and function of circulating regulatory T-cells in biliary atresia. Pediatric surgery international. 2022. 39. 1. 23-23
文田貴志, 坂本明美, 藤村理紗, 照井慶太, 中田光政, 小松秀吾, 柴田涼平, 菱木知郎, 幡野雅彦. Ncx KOマウスにおける腸管神経系異常疾患と腸管免疫の関与の検討. 日本小児外科学会雑誌. 2022. 58. 3. 523-523
Eizo Watanabe, Toshinobu Akamatsu, Masaaki Ohmori, Mayu Kato, Noriko Takeuchi, Naruhiko Ishiwada, Rintaro Nishimura, Haruka Hishiki, Lisa Fujimura, Chizuru Ito, et al. Recombinant thrombomodulin attenuates hyper-inflammation and glycocalyx damage in a murine model of Streptococcus pneumoniae-induced sepsis. Cytokine. 2022. 149. 155723-155723
Yoshitoshi Kasuya, Jun-Dal Kim, Masahiko Hatano, Koichiro Tatsumi, Shuichi Matsuda. Pathophysiological Roles of Stress-Activated Protein Kinases in Pulmonary Fibrosis. International journal of molecular sciences. 2021. 22. 11

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MISC (231)：

渡邉栄三, 林洋輔, 林洋輔, 大網毅彦, 藤村理紗, 幡野雅彦. 敗血症病態におけるMitophagyの役割とその制御の可能性. 外科と代謝・栄養. 2021. 55. 4
渡邉栄三, 渡邉栄三, 渡邉栄三, 大網毅彦, 砂原聡, 高橋和香, 幡野雅彦, 織田成人. 敗血症におけるオートファジーの関与とその制御を企図する集中治療. 日本集中治療医学会学術集会(Web). 2018. 45th
渡邉栄三, 渡邉栄三, 大網毅彦, 砂原聡, 橋田知明, 幡野雅彦, 織田成人. 敗血症性ショックにおけるプログラム細胞死の役割とその制御. 日本救急医学会雑誌. 2018. 29. 10
Iliroki Umezawa, Yusuke Naito, Kensuke Tanaka, Kento Yoshioka, Tatsuhiko Sudo, Masahiko Hagihara, Masahiko Hatano, Koichiro Tatsumi, Yoshitoshi Kasuya. Inhibition of p38 alpha improved functional outcome in a mouse model of spinal cord injury: the involvement of p38 alpha in tissue regeneration. JOURNAL OF PHARMACOLOGICAL SCIENCES. 2017. 133. 3. S130-S130
Kento Yoshioka, Kana Namiki, Tatsuhiko Sudo, Yoshitoshi Kasuya, Masahiko Hatano. In vitro expansion of neural stem cells derived from the adult hippocampus. JOURNAL OF PHARMACOLOGICAL SCIENCES. 2017. 133. 3. S113-S113

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Works (4)：

Molecular mechanism of neuronal cell death by Ncx gene
Molecular mechanism of T cell differentiation and proliferation
Ncx遺伝子による神経細胞死誘導の分子機構
T細胞の分化・増殖の分子機構

Professional career (1)：

(BLANK) (Kobe University)

Association Membership(s) (3)：

日本癌学会 , 日本分子生物学会 , 日本免疫学会

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