Rchr

J-GLOBAL ID：200901031695970561 Update date: Apr. 17, 2024

Nakazawa Takashi

ナカザワタカシ | Nakazawa Takashi

Affiliation and department：
Other affiliations (2)：

Nara Women's University
Nara Women's University Professor

Research field (9)： Biophysics , Museology , Cultural properties , Analytical chemistry , Archaeology , Bioorganic chemistry , Structural/physical organic chemistry , Structural biochemistry , Molecular biochemistry

Research keywords (12)：文化財科学 , 核磁気共鳴法 , 質量分析学 , 有機化学 , プロテオミクス , タンパク質科学 , Archaeological Science. , Nuclear Magnetic Resonance , Mass Spectrometry , Organic Chemistry , Proteomics , Protein Science

Research theme for competitive and other funds (40)：

2022 - 2025 Protein archaeological study on exploring the possibility of natural hybridization between sheep and goat in the history of herding.
2023 - 2025 Experimental study on the progress and development of herding activity from ancient west Asia to China by protein archaeology.
2019 - 2021 Protein archaeological study of Paleolithic animal bones
2017 - 2021 旧石器時代から新石器時代の動物骨に含まれるコラーゲンのアミノ酸配列解析による動物種の判定と劣化状態の評価法の確立
2017 - 2021 Identification of species of animal bones excavated from the Neolithic and Paleolithic sites by the amino acid sequencing of collagen.

2017 - 2020 Archaeology of early domestic animals in the southern Caucasus: examinations of their phylogeny and pasture range

2016 - 2020 Oversea's Research on Archaeological Proteins as Molecular Markers of Ancient Culture and Civilization

2017 - 2019 Study on Palaeolithic Aminal Bones by Protein Archaeology

2014 - 2018 Research on the animal glue production in ancient East Asia

2012 - 2015 Development of N- and C-terminal sequencing method for proteins with posttranslational modification

2010 - 2012 Stable oxygen isotope of opal phytoliths: Basic information toward the paleoenvironmental reconstruction

2009 - 2011 Enhancing the practicability of the method for proteome analysis based on a new isolation scheme of C-terminal peptides.

1999 - 2009 タンパク質のC末端活性化法の開発

1999 - 2009 Development of the method for the C-terminal activation of proteins

2007 - 2008 NMR and MM Analysis of Tautomerization of His64 Coupled to Ionization of Zinc-bound Solvent during Proton Transfer in Carbonic Anhydrase

2006 - 2008 Development of the method for proteome analysis based on a novel chemical derivatization specific to C-termini of proteins

2008 - 文化財に含まれる膠のコラーゲンのアミノ酸配列解析による動物種の特定法に関する研究

2008 - Development of the method for the specific identification of animals based on amino acid sequencing of collagen in archaeological samples using mass spectrometry.

2007 - ヒスチジンをミクロ環境プローブとするタンパク質の動的構造解析

2007 - Analysis of dynamic structure of proteins using histidine residues to be probing micro-environment.

2003 - 2006 Development of Highly Sensitive, Accurate, and Quantitative Analytical System for Proteome

1999 - 2001 Development of a method allowing high resolution X-ray crystallographic analysis of proteins by site-specific heavy-atom labeling

2000 - コラーゲンモデルペプチドの構造研究

2000 - Structural research of collagen model peptides

1999 - プロテオミクスのための化学的方法の開発

1999 - Development of Chemical Methods for Proteomics Studies

1996 - 1996 新最適化アルゴリズムによるタンパク質の折れたたみの研究

1995 - 1995 新最適化アルゴリズムによるタンパク質の折れたたみ機構の研究

1992 - 1993 Tertiary structure prediction of peptides by Monte Carlo simulated annealing and its experimental verification

1988 - セリンプロテアーゼの化学修飾による基質特異性の改変

1988 - Alteration of substrate specificity of serine proteases by chemical modification

古代のタンパク質のプロテオミクス(タンパク質考古学)

タンパク質の化学修飾による機能改変および解析

エネルギー最小化によるペプチド,タンパク質の非経験的立体構造予測

デヒドロアミノ酸含有ペプチドの合成

Protein Archaeology

Functional Alteration and Analysis of Proteins by Chemical Modification

Heavy-atom Labeling of Proteins for High-Resolution X-Ray Analyses

ab initio prediction of tertiary structure of peptides and proteins by energy minimization

Synthesis of dehydroamino-acid-containing peptides

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Papers (92)：

Masaru Miyagi, Evan Kiesel, Kelao Neumbo, Takashi Nakazawa. Deuterium Labeling of Isoaspartic and Isoglutamic Acids for Mass Spectrometry Analysis. Analytical Chemistry. 2024. 96. 7. 3077-3086
Masaru Miyagi, Takashi Nakazawa. Significance of Histidine Hydrogen-Deuterium Exchange Mass Spectrometry in Protein Structural Biology. Biology. 2024. 13. 1. 37-37
中澤隆. 化学的視点から見る考古学資料: 経年劣化したタンパク質から何がわかるのか?. 化学. 2023. 78. 4. 23-26
Yoko Taniguchi, Kazuki Kawahara, Miho Takashima, Marine Cotte, Joy Mazurek, Yuki Kumazawa, Yuki Taga, Takashi Nakazawa. Organic Materials Used for Giant Buddhas and Wall Paintings in Bamiyan, Afghanistan. Applied Sciences. 2022. 12. 19. 9476-9476
Yuichi I. Naito, Masato Hirose, Miriam Belmaker, Donald O. Henry, Momoko Osawa, Takashi Nakazawa, Sophie G. Habinger, Peter Tung, Hervé Bocherens, Sate Massadeh, et al. Paleoenvironment and human hunting activity during MIS 2 in southern Jordan: Isotope records of prey remains and paleosols. Quaternary Science Reviews. 2022. 282. 107432-107432

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MISC (31)：

NAKAZAWA Takashi. Protein archaeology: study of animal bones from the Paleolithic sites. 2018. 708. 35-38
NAKAZAWA Takashi, Takashi Nakazawa. History of Japannese sericulture in view of the species of silk moth - Literary records of domesticated and wild Japanese silk moths in ancient Japan -. 2017. 9. 1-10
KOYIMATU Muhamad, 島原秀登, 杉森公一, 岩山将士, 杉森哲也, 川口一朋, 齊藤大明, 吉田卓也, 中沢隆, 大久保忠恭, et al. 炭酸脱水酵素の水素結合ネットワークとHis64. 分子科学討論会講演プログラム&要旨(Web). 2012. 6th
MOTOOKA Daisuke, KAWAHARA Kazuki, NAKAMURA Shota, DOI Masamitsu, NISHIUCHI Yuji, NAKAZAWA Takashi, OHKUBO Tadayasu, KOBAYSHI Yuji. The Crystal Structure of the Collagen Model Peptide containing 4(S)-hydroxyproline-proline-glycine Repeats. 2011. 2010. 153-153
The Mutation in the Hydrogen Bond Relay between the Glu-His effects on the Tautomerism of His and on the Behavior of H2O, Incresing the Kinetic Rate of Carbonic Anhydrase-QM and NMR Analysis-. 2011. 34th. WEB ONLY 3T18PI-4

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Patents (22)：

Method for selectively collecting N-terminal peptide fragment of protein
Method for modifying protein or peptide C-terminal
タンパク質のN末端フラグメントを選択的に回収する方法
イソチオシアネート基を有する金属錯体、及びそれを用いるタンパク質のアミノ酸配列決定方法
ペプチドのアミノ酸配列決定法

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Books (4)：

纒向遺跡の絹が語る古代日本の養蚕
化学 2013
Sericulture of ancient Japan as revealed by silk excavated from the ruin of Makimuku
Chemistry 2013
生命元素事典
オーム社 2006
生体成分のFD-Massによる分析
講談社 1982

Lectures and oral presentations (19)：

Mass Spectrometry of Collagen and Casein in the Remains of the 5th to 7th Century Bamiyan Buddhas
(64th ASMS Conference on Mass Spectrometry and Allied Topics 2016)
How Collagen Molecules Get Older? - A Strange Life of Collagen -
(Workshop 03: Art and Cultural Heritage Mass Spectrometry In 64th ASMS Conference on Mass Spectrometry and Allied Topics 2016)
Mass Spectrometry of Collagen and Casein in the Remains of the 5th to 7th Century Bamiyan Buddhas
(64th ASMS Conference on Mass Spectrometry and Allied Topics 2016)
How Collagen Molecules Get Older? - A Strange Life of Collagen -
(Workshop 03: Art and Cultural Heritage Mass Spectrometry In 64th ASMS Conference on Mass Spectrometry and Allied Topics 2016)
エジプトの膠
(シンポジウム:西アジア発掘と関連科学 2015)

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Works (2)：

コラーゲンの三本鎖へリックス構造形成機構の研究
Physicochemical studies on the mechanism of the collagen triple helix

Education (3)：

1979 - 1982 Osaka University Graduate School, Division of Natural Science
1977 - 1979 Osaka University
1973 - 1977 Osaka University School of Science

Professional career (1)：

Doctor of Science (Osaka University)

Work history (14)：

2020/04 - 現在 The Open University of Japan
2020/04 - 現在 Nara Women's University
2008/04 - 2020/03 奈良女子大学・理学部・教授
2007 - 2008 :奈良女子大学・理学部・准教授
1993 - 2007 :奈良女子大学・理学部・助教授

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Committee career (5)：

2013/08 - 日本分析化学会近畿支部幹事
2011/10 - 2012/10 日本化学会代議員
2012/04 - 日本生化学会評議員
2012/04 - Biochemical Society of Japan Fellow
2004/01 - 2011/12 有機合成協会幹事(関西支部)

Association Membership(s) (16)：

日本化学会 , American Chemical Society , American Society for Mass Spectrometry , 有機合成協会 , 日本生化学会 , 日本文化財科学会 , 日本質量分析学会 , 日本蛋白質科学会 , 日本分析化学会 , Chemical Society of Japan , American Chemical Society , American Society for Mass Spectrometry , Biochemical Society of Japan , The Mass Spectrometry Society of Japan , Protein Society of Japan , The Japan Society for Analytical Chemistry

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