Tagawa Kazuhiko

タガワカズヒコ | Tagawa Kazuhiko

Affiliation and department：
Job title： Associate Professor
Homepage URL (2)： http://www.tmd.ac.jp/mri/npat/index.html , http://www.tmd.ac.jp/english/npat/index.html

Research field (1)： Molecular biology

Research keywords (3)： molecular neuropathology , molecular and cellular biology , Biochemistry

Research theme for competitive and other funds (7)：

2016 - 2021 神経変性誘発因子HMGB1を標的とするヒト化抗体治療法およびコンパニオン診断法の開発
2016 - 2018 アルツハイマー病において早期に変化する分子の病態分子機構の解明
2012 - 2014 脊髄小脳失調症I型における複合体タンパク質プロテオーム解析による分子病態の解明
2005 - 2006 小脳神経細胞特異的に発現誘導されるHsp70を制御する因子の同定と治療への応用
2000 - 2001 The roles of laminin and its membrane receptors on muscular dystrophies

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Papers (74)：

Yuki Yoshioka, Juliana Bosso Taniguchi, Hidenori Homma, Takuya Tamura, Kyota Fujita, Maiko Inotsume, Kazuhiko Tagawa, Kazuharu Misawa, Naomichi Matsumoto, Masanori Nakagawa, et al. AAV-mediated editing of PMP22 rescues Charcot-Marie-Tooth disease type 1A features in patient-derived iPS Schwann cells. Communications medicine. 2023. 3. 1. 170-170
本間秀典, Jin Meihua, Jin Xiaocen, 藤田慶大, 田中ひかり, 田川一彦, 岡澤均. 動的分子ネットワーク解析法に基づくAD-FTLD間の共通病態ネットワーク予測. Dementia Japan. 2022. 36. 4. 761-761
Hikari Tanaka, Kanoh Kondo, Kyota Fujita, Hidenori Homma, Kazuhiko Tagawa, Xiaocen Jin, Meihua Jin, Yuki Yoshioka, Sumire Takayama, Hitomi Masuda, et al. HMGB1 signaling phosphorylates Ku70 and impairs DNA damage repair in Alzheimer's disease pathology. Communications biology. 2021. 4. 1. 1175-1175
藤田慶大, 本間秀典, 田中ひかり, Jin Meihua, Jin Xiaocen, Huang Yong, 吉岡優希, 近藤和, 塩飽裕紀, 田川一彦, et al. 胎児期神経幹細胞のDNA損傷が早期神経細胞ネクローシスを介してFTLD発症を運命付ける. Dementia Japan. 2021. 35. 4. 609-609
Meihua Jin, Xiaocen Jin, Hidenori Homma, Kyota Fujita, Hikari Tanaka, Shigeo Murayama, Hiroyasu Akatsu, Kazuhiko Tagawa, Hitoshi Okazawa. Prediction and verification of the AD-FTLD common pathomechanism based on dynamic molecular network analysis. Communications biology. 2021. 4. 1. 961-961

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MISC (16)：

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Lectures and oral presentations (20)：

RPA1 AMELIORATES SYMPTOMS OF MUTANT ATAXIN-1 KNOCK-IN MICE AND ENHANCE DNA DAMAGE REPAIR
(XXIII World Congress of Neurology (WCN 2017) 合同開催:第58回日本神経学会学術大会・第23回世界神経学会議 2017)
HMGB1 TRIGGERS NEURITE DEGENERATION VIA TLR4-MARCKS, AND IS A POTENTIAL THERAPEUTIC TARGET FOR ALZHEIMER’S DISEASE
(XXIII World Congress of Neurology (WCN 2017) 合同開催:第58回日本神経学会学術大会・第23回世界神経学会議 2017)
Targeting TEAD/YAP-transcription-dependent necrosis, TRIAD, ameliorates Huntington's disease pathology
(第40回日本神経科学大会 2017)
RpA1 ameliorates symptoms of mutant ataxin-1 knock-in mice and enhances DNA damage repair
(第40回日本神経科学大会 2017)
HMGB1, a pathogenic molecule that induces neurite degeneration via TLR4-MARCKS, is a potential therapeutic target for Alzheimer's disease
(第40回日本神経科学大会 2017)

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Work history (3)：

2011/10/01 - 現在 Tokyo Medical and Dental University Graduate School of Medical and Dental Sciences Medical and Dental Sciences Cognitive and Behavioral Medicine Neuropathology Associate Professor
2011/10/01 - 現在 Tokyo Medical and Dental University Medical Research Institute Pathophysiology Neuropathology Associate Professor
2010/09/01 - 2011/09/30 Tokyo Medical and Dental University Medical Research Institute Pathophysiology Neuropathology Project Junior Associate Professor

Association Membership(s) (2)：

日本生化学会 , 日本分子生物学会

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