Rchr
J-GLOBAL ID：200901032348036677   Update date: Feb. 01, 2024

Okazaki Taku

オカザキ タク | Okazaki Taku
Affiliation and department：
The University of Tokyo

About The University of Tokyo


Job title： Professor
Homepage URL  (1)： https://www.iqb.u-tokyo.ac.jp/okazakilab/
Research field  (5)： Experimental pathology ,  Medical biochemistry ,  Pathobiochemistry ,  Immunology ,  Genetics
Research keywords  (6)： co-receptor ,  Cancer Immunology ,  Molecular Biology ,  Genetic analysis ,  Autoimmunity ,  Immunology
Research theme for competitive and other funds  (23)：
  • 2022 - 2025 Regulation of immunological synapse by co-receptors
  • 2018 - 2023 Singularity cells in immunity and cancer development
  • 2019 - 2022 Elucidating the regulatory mechanisms of PD-1 function
  • 2012 - 2014 マウスにおける母仔遺伝的コンフリクト回避機構の解明
  • 2012 - 2014 Identification of genes that regulate allergic diseases.
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Papers (72)：
  • Jianshi Jin, Taisaku Ogawa, Nozomi Hojo, Kirill Kryukov, Kenji Shimizu, Tomokatsu Ikawa, Tadashi Imanishi, Taku Okazaki, Katsuyuki Shiroguchi. Robotic data acquisition with deep learning enables cell image-based prediction of transcriptomic phenotypes. Proceedings of the National Academy of Sciences of the United States of America. 2023. 120. 1. e2210283120
  • Takumi Maruhashi, Daisuke Sugiura, Il-Mi Okazaki, Kenji Shimizu, Takeo K Maeda, Jun Ikubo, Harunori Yoshikawa, Katsumi Maenaka, Naozumi Ishimaru, Hidetaka Kosako, et al. Binding of LAG-3 to stable peptide-MHC class II limits T cell function and suppresses autoimmunity and anti-cancer immunity. Immunity. 2022. 55. 5. 912-924
  • Daisuke Sugiura, Il-Mi Okazaki, Takeo K Maeda, Takumi Maruhashi, Kenji Shimizu, Rieko Arakaki, Tatsuya Takemoto, Naozumi Ishimaru, Taku Okazaki. PD-1 agonism by anti-CD80 inhibits T cell activation and alleviates autoimmunity. Nature immunology. 2022. 23. 3. 399-410
  • Daisuke Sugiura, Kenji Shimizu, Takumi Maruhashi, Il-Mi Okazaki, Taku Okazaki. T cell-intrinsic and -extrinsic regulation of PD-1 function. International immunology. 2021. 33. 12. 693-698
  • Yasuhiro Kanda, Taku Okazaki, Tomoya Katakai. Motility Dynamics of T Cells in Tumor-Draining Lymph Nodes: A Rational Indicator of Antitumor Response and Immune Checkpoint Blockade. Cancers. 2021. 13. 18. 4616-4616
ｍore...
MISC (39)：
  • 丸橋拓海, 岡崎 拓. LAG-3による自己免疫とがん免疫の抑制機構. 感染・炎症・免疫. 2023. 53. 1. 19-29
  • 丸橋拓海, 杉浦大祐, 岡崎 拓. 免疫チェックポイント阻害剤の作用メカニズ. 実験医学. 2022. 40. 20. 3340-3345
  • 岡崎一美, 岡崎 拓. 免疫チェックポイント分子と自己免疫. 実験医学. 2022. 40. 15. 2420-2426
  • 杉浦大祐, 岡崎 拓. PD-1の機能制限解除による自己免疫疾患の治療. 実験医学. 2022. 40. 13. 2172-2175
  • 清水謙次, 岡崎 拓. PD-1は抗原親和性の低いT細胞の活性化を選択的に抑制する. 臨床免疫・アレルギー科. 2022. 77. 5. 630-636
ｍore...
Patents (3)：
Education (2)：
  • 1999 - 2003 Kyoto University Graduate School of Medicine
  • 1993 - 1999 Kyoto University Faculty of Medicine Department of Medical Science
Professional career (1)：
  • M.D., Ph.D. (Kyoto University)
Work history (7)：
  • 2019/11 - 現在 The University of Tokyo Institute for Quantitative Biosciences Professor
  • 2016/04 - 2019/10 The University of Tokushima Institute of Advanced Medical Sciences Professor
  • 2008/04 - 2016/03 The University of Tokushima Institute for Genome Research Professor
  • 2004/01 - 2008/03 Kyoto University Graduate School of Medicine Associate Professor
  • 2003/08 - 2003/12 Kyoto University Graduate School of Medicine Assistant Professor
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Association Membership(s) (4)：
日本生化学会 ,  日本免疫学会 ,  日本分子生物学会 ,  日本癌学会
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