Tashima Kimihito

田嶋公人 | Tashima Kimihito

Affiliation and department：
Job title： Professor

Research field (2)： Pharmacology , Pharmacology

Research keywords (6)： Gastroduodenal mucosal micro-inflammation , Allyl-isothiocyanate , TRPA1 channel , Tight junction , Functional gastrointestinal disorders , TRPV1 channel

Research theme for competitive and other funds (6)：

2017 - 2020 The new rodent models for impaired gastric motility induced by allyl isothiocyanate and/or bile acid -the evaluation of traditional Kampo medicine-
2014 - 2017 Allyl isothiocyanate, a pungent ingredient of wasabi, induces gastric low-grade inflammation in rodents to lead to the impaired gastric motility for the development of functional dyspepsia
2012 - 2015 A rodent model of impaired gastric motility resulting from gastric low-grade inflammation induced by allyl isothiocyanate to evaluate therapeutic agents for functional dyspepsia
2010 - 2011 生姜・乾姜と温度感受性TRPチャネル
2008 - 2009 大建中湯の胃機能に対する薬理作用

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Papers (50)：

Noriyuki Ohashi, Kimihito Tashima, Takao Namiki, Syunji Horie. Allyl isothiocyanate, an activator of TRPA1, increases gastric mucosal blood flow through calcitonin gene-related peptide and adrenomedullin in anesthetized rats. Journal of pharmacological sciences. 2023. 151. 4. 187-194
Masatoshi Yoshikubo, Kimihito Tashima, Masaki Raimura, Yuto Watanabe, Yukiko Noma, Syunji Horie. Daikenchuto, a Traditional Kampo Medicine, Facilitates Mucosal Hyperemic Responses through Activation of TRPA1- and TRPV1-Expressing Sensory Nerves in Rat Stomach. Planta Medica International Open. 2022. 9. 01. e72-e79
Kazuki Hashimoto, Kimihito Tashima, Taku Imai, Kenjiro Matsumoto, Syunji Horie. The rodent model of impaired gastric motility induced by allyl isothiocyanate, a pungent ingredient of wasabi, to evaluate therapeutic agents for functional dyspepsia. Journal of Pharmacological Sciences. 2021. 145. 1. 122-129
Syunji Horie, Kimihito Tashima, Kenjiro Matsumoto. [Gastrointestinal Spice Sensors and Their Functions]. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan. 2018. 138. 8. 1003-1009
Kenjiro Matsumoto, Kanako Takagi, Atsumi Kato, Takuya Ishibashi, Yasuo Mori, Kimihito Tashima, Atsushi Mitsumoto, Shinichi Kato, Syunji Horie. Role of transient receptor potential melastatin 2 (TRPM2) channels in visceral nociception and hypersensitivity. Experimental neurology. 2016. 285. Pt A. 41-50

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MISC (76)：

Tashima Kimihito, Oshige Marina, Fujii Yoko, Horie Syunji. Allyl isothiocyanate-induced acute inflammation in the gastric mucosa leads to the impaired gastric motility in rodents: involvement of substance P and calcitonin gene-related peptide, but not mast cells. Proceedings for Annual Meeting of The Japanese Pharmacological Society. 2022. 96. 1-B-P-053
趙春暁, 田嶋公人, 並木隆雄, 堀江俊治. センノシドA誘発慢性結腸通過遅延マウスモデルにおける結腸運動に対する大建中湯の改善作用. 応用薬理. 2021. 100. 5-6. 138-138
田嶋公人. 胆汁酸を用いた新規機能性ディスペプシア病態モデルマウス開発の試み-ワサビ辛味成分アリルイソチオシアネート誘起病態モデルとの比較-. Ulcer Research. 2020. 47
田嶋公人, 吉久保匡甫, 内木蓮, 後藤友希, 島田博文, 大重茉里奈, 並木隆雄, 堀江俊治. 消化管疾患に対する漢方薬のエビデンスの構築をめざして実験動物を用いた大建中湯による胃腸機能の改善作用温度感受性TRPA1とTRPV1チャネルの関与. 日本消化管学会雑誌. 2020. 4. Suppl. 163-163
田嶋公人, 後藤友希, 島田博文, 並木隆雄, 堀江俊治. 摘出マウス結腸における大建中湯による平滑筋収縮作用 TRPチャネルとカルシトニン遺伝子関連ペプチド. 和漢医薬学会学術大会要旨集. 2019. 36回. 96-96

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Books (2)：

Capsaicin-sensitive neural afferntation and the gastrointestinal tract: from bench to bedside
Intech open science 2014 ISBN:9789535116318
Capsaicin-sensitive neural afferntation and the gastrointestinal tract: from bench to bedside
Intech open science 2014 ISBN:9789535116318

Work history (4)：

2021/04 - 現在 Josai International University Faculty of Pharmaceutical Sciences Department of Clinical Pharmacy Professor
2011/04 - 2021/03 Josai International University Faculty of Pharmaceutical Sciences Department of Clinical Pharmacy Associate Professor
2001/05 - 2005/03 Beth Israel Deaconess Medical Center (BIDMC) Department of Surgery Postdoctoral fellow
2001/04 - 2001/05 Kyoto Pharmaceutical University Graduate School of Pharmaceutical Sciences Postdoctoral fellow

Awards (6)：

2022/02 - 一般社団法人日本潰瘍学会第49回日本潰瘍学会学会賞
2019/07 - 千葉消化管機能研究会第20回千葉消化管研究機能研究会賞受賞
2015/11 - 日本神経消化器病学会第17回日本神経消化器病学会優秀演題賞
2014/03 - 学校法人城西大学平成25年度城西国際大学 Best Young Teacher Award
2010/11 - 一般社団法人日本潰瘍学会第38回日本潰瘍学会奨励賞

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Association Membership(s) (8)：

一般社団法人日本薬学教育学会 , 一般社団法人和漢医薬学会 , 日本神経消化器病学会 , 一般社団法人日本消化管学会 , 公益社団法人日本薬学会 , American Gastroenterology Association , The Japanese Pharmacological Society , Ulcer Research

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