Asai Tomohiro

アサイトモヒロ | Asai Tomohiro

Affiliation and department：
Job title： Assistant Professor

Research field (1)： Pharmaceuticals - health and biochemistry

Research keywords (3)： DDS , Medical molecular biology , Biochemistry

Research theme for competitive and other funds (27)：

2022 - 2025 抗原提示細胞を標的としたmRNA/LNP製剤の開発と個別化がん免疫療法への応用
2020 - 2022 Design and construction of neutrophil-mediated drug delivery system
2019 - 2022 Clarification of the molecular mechanism and establishment of the basis for drug development toward epithelial cancer barrier
2019 - 2022 Development of plastic antibodies that inhibit intestinal absorption of target molecules
2018 - 2021 Innovative DDS medicine for the complete recovery from autoimmune diseases

2016 - 2020 Development of treatment of rabies using drug delivery system to virus-infected cells

2016 - 2019 Development of FA-Snap, a smart DDS drug, for proposing an innovative therapeutic modality of ischemic stroke.

2016 - 2019 Development of functional lipid nanoparticles for RNA interference-based therapy

2016 - 2018 Development of liposomal plastic antibody for novelDDS and applicaion for sepsis treatment

2015 - 2018 Development of antibody-drug conjugate to diagnose and treat vulnerable plaque

2013 - 2017 The development of treatment of rabies by injection of nanoparticle-encapsulated intracellular antibodies

2014 - 2016 Novel strategy of tumor treatiment via the normalization of tumor vasculature by microRNA

2013 - 2016 Delivery of siRNA for synthetic lethality-based cancer therapy

2013 - 2016 Epigenetic regulation of macrophage function in inflammatory bowel disease

2012 - 2014 Innovation of a novel technology for supporting the development of DDS drugs and protein medicines by controling their pharmacokinetics.

2010 - 2012 Systemic delivery system of siRNAfor cancertreatment

2010 - 2011 Development of novel nanoparticles for DDS, and establishment of Therapeutic modality for brain ischemia by use of these nanoparticles.

2008 - 2010 A novel targeting DDS for the treatment of autoimmune diseases and allergy

2008 - 2009 難治がんの克服を目標した発展型腫瘍新生血管標的化DDSに関する研究

2007 - 2009 Development of systemic delivery system for RNAi-based therapies

2006 - 2007 Development of Radical Treatment Modality for Curing Allergies and Immune Diseases by a Novel Consept, RTDDS

2005 - 2006 腫瘍新生血管傷害療法を応用した膵がんに対する新規アプローチ

2005 - 2005 難治がんの克服を目標とした腫瘍新生血管標的化DDSに関する包括的研究

2003 - 2005 Establishment of Antineovascular Therapy by use of Structure-recognizing targeting probes

1999 - 2001 新生血管を標的とする低分子リガンドを用いたがん治療のDDS新戦略

siRNA delivery

angiogenic vessel-targeted liposomes

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Papers (160)：

Hiroyuki Koide, Chiaki Kiyokawa, Anna Okishima, Kaito Saito, Keiichi Yoshimatsu, Tatsuya Fukuta, Yu Hoshino, Tomohiro Asai, Yuri Nishimura, Yoshiko Miura, et al. Design of an Anti-HMGB1 Synthetic Antibody for In Vivo Ischemic/Reperfusion Injury Therapy. Journal of the American Chemical Society. 2023
Masahiro Hashimoto, Sei Yonezawa, Song Furan, Chiori Nitta, Noriyuki Maeda, Koji Tomita, Ayano Yokouchi, Hiroyuki Koide, Tomohiro Asai. Increasing the siRNA knockdown efficiency of lipid nanoparticles by morphological transformation with the use of dihydrosphingomyelin as a helper lipid. Biomaterials science. 2023. 11. 9. 3269-3277
Hiroyuki Koide, Kazuhiro Saito, Keiichi Yoshimatsu, Beverly Chou, Yu Hoshino, Sei Yonezawa, Naoto Oku, Tomohiro Asai, Kenneth J Shea. Cooling-induced, localized release of cytotoxic peptides from engineered polymer nanoparticles in living mice for cancer therapy. Journal of controlled release : official journal of the Controlled Release Society. 2023. 355. 745-759
Tomohiro Asai, Masafumi Yokota, Hideki Isomura, Hiroyuki Koide, Naoyuki Sakurai, Ayaka Okamoto, Hidenori Ando, Takehisa Dewa, Naoto Oku. Treatment of PTEN-Null Breast Cancer by a Synthetic Lethal Approach Involving PARP1 Gene Silencing. Journal of pharmaceutical sciences. 2023
Hiroyuki Koide, Hiroki Ochiai, Hikaru Suzuki, Shinya Hirata, Midori Watanabe, Sei Yonezawa, Takehisa Dewa, Naoto Oku, Tomohiro Asai. Easy preparation of a liposome-mediated protein delivery system by freeze-thawing a liposome-protein complex. Journal of materials chemistry. B. 2022. 10. 35. 6768-6776

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MISC (44)：

渡邊翠, 小出裕之, 平田真也, 米澤正, 出羽毅久, 奥直人, 奥直人, 浅井知浩. Development of protein delivery strategy using multi-functionalized liposomes. 日本薬剤学会年会講演要旨集(CD-ROM). 2023. 38th
又吉克樹, 龍聡平, 高橋沙也加, 米澤正, 尾崎奈穂子, 田中陽平, 浅井知浩. 新規pH応答性ペプチド脂質を基盤とするmRNA/LNP製剤の設計. 生体膜と薬物の相互作用シンポジウム講演要旨集. 2022. 43rd
安野豪, 小出裕之, 米澤正, 浅井知浩. Influence of purification method of synthetic polymer nanoparticle on the function. 日本薬学会年会要旨集(Web). 2021. 141st
米澤正, 林純衣, 小出裕之, 川崎靖, 杉山晶規, 浅井知浩. Development of tubulointerstitial-targeting drug delivery system in Zucker Diabetic Fatty Rat. 日本薬学会年会要旨集(Web). 2021. 141st
宋復燃, 森本誠士郎, 山本裕和, 小出裕之, 米澤正, 浅井知浩. 血栓標的化2剤内封リポソームの開発とがん治療応用. 日本DDS学会学術集会プログラム予稿集. 2021. 37th

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Books (5)：

DDS先端技術の製剤への応用開発
株式会社技術情報協会 2017
リポソーム応用の新展開
株式会社エヌ・ティー・エス 2015
DDSキャリア作成プロトコル集
株式会社シーエムシー出版 2015
DDS技術の実用化手法
株式会社技術情報協会 2013
非経口投与製剤の開発と応用-次世代型医薬品の新規投与形態の開拓を目指して-
株式会社シーエムシー出版 2013

Education (1)：

- 1998 University of Shizuoka Graduate School, Division of Pharmaceutical Sciences

Professional career (1)：

(BLANK)

Work history (7)：

2018/04 - 現在 University of Shizuoka School of Pharmaceutical Sciences
2013/04 - 2018/03 University of Shizuoka School of Pharmaceutical Sciences
2004/02 - 2013/03 University of Shizuoka School of Pharmaceutical Sciences
2011/07 - 2012/06 University of North Carolina・Visiting Scholar
2005/10 - 2005/12 University of North Carolina・Visiting Scholar

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Awards (9)：

2016/03 - 静岡県立大学教員活動評価学長表彰
2014/05 - 日本薬剤学会奨励賞
2011/07 - 日本薬学会東海支部奨励賞
2011/03 - 日本薬学会奨励賞
2009/10 - The APSTJ Global Education Seminar Presentation Award 2009

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Association Membership(s) (5)：

THE JAPANESE BIOCHEMICAL SOCIETY , 日本薬剤学会 , 日本DDS学会 , 日本薬学会 , 日本核酸医薬学会

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