Yamagata Kazutsune

ヤマガタカズツネ | Yamagata Kazutsune

Affiliation and department：
Job title： Research associate

Research field (1)： Hematology and oncology

Research keywords (4)： Lipid metabolism , epigenetics , transcription , AML

Research theme for competitive and other funds (8)：

2023 - 2026 脂質代謝経路を介した急性骨髄性白血病の発症、及び予後不良化メカニズムの解明
2022 - 2025 Proposal for the construction of library for lipid metabolite of diseaese
2020 - 2023 急性骨髄性白血病における新規分子標的の単離
2022 - 2023 Development of AML treatment targeting lipid metabolism
2016 - 2021 Development of novel therapeutic agent targeting histone acetyltransferase complex

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Papers (26)：

Ayuna Hattori, Emi Takamatsu-Ichihara, Yoshiki Yamamoto, Shuhei Fujita, Kazutsune Yamagata, Takuo Katsumoto, Yukino Machida, Haruka Shinohara, Ryo Murakami, Issay Kitabayashi. Genetic and chemical targeting of the ATPase complex TIP48 and 49 impairs acute myeloid leukemia. Leukemia. 2023
Haruka Shinohara, Rie Sawado, Makoto Nakagawa, Ayuna Hattori, Kazutsune Yamagata, Kimiharu Tauchi, Jumpei Ito, Yasumichi Kuwahara, Tsukasa Okuda, Chitose Ogawa, et al. Dual targeting of EZH1 and EZH2 for the treatment of malignant rhabdoid tumors. Molecular therapy oncolytics. 2022. 27. 14-25
Jumpei Ito, Kazutsune Yamagata, Haruka Shinohara, Yutaka Shima, Takuo Katsumoto, Yukiko Aikawa, Issay Kitabayashi. Dual inhibition of EZH1/2 induces cell cycle arrest of B cell acute lymphoblastic leukemia cells through upregulation of CDKN1C and TP53INP1. International Journal of Hematology. 2022. 117. 1. 78-89
Takuo Katsumoto, Yoko Ogawara, Kazutsune Yamagata, Yukiko Aikawa, Ryo Goitsuka, Takuro Nakamura, Issay Kitabayashi. MOZ is critical for the development of MOZ/MLL-fusion-induced leukemia through regulation of Hoxa9/Meis1 expression. Blood Advances. 2022. 6. 19. 5527-5537
Issay Kitabayashi, Yukiko Aikawa, Kazutsune Yamagata, Takuo Katsumoto, Yutaka Shima, Akihiko Yokoyama, Yukino Machida, Haruka Shinohara, Yoko Ogawara, Shuhei Fujita, et al. Targeting driver mutations and critical factors in hematological and solid cancers. CANCER SCIENCE. 2022. 113. 1256-1256

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MISC (33)：

山形和恒, 北林一生. 脂質代謝による急性骨髄性白血病の制御. がんと代謝研究会プログラム&抄録集. 2022. 8th
北林一生, 相川祐規子, 山形和恒, 勝本拓夫, 島豊, 横山明彦, 町田雪乃, 篠原悠, 小川原陽子, 藤田修平, et al. ドライバー変異と必須因子を標的とした分子標的治療法の開発を目指して. 日本癌学会総会記事. 2021. 80回. [MVA-4]
北林一生, 相川祐規子, 山形和恒, 勝本拓夫, 島豊, 横山明彦, 町田雪乃, 篠原悠, 小川原陽子, 藤田修平, et al. ドライバー変異と必須因子を標的とした分子標的治療法の開発を目指して. 日本癌学会学術総会抄録集(Web). 2021. 80th
OGOH Honami, YAMAGATA Kazutsune, NAKAO Tomomi, SANDELL Lisa L., YAMAMOTO Ayaka, YAMASHITA Aiko, TANGA Naomi, SUZUKI Mai, ABE Takaya, KITABAYASHI Issay, et al. Deregulation of histone methylation is implicated in the etiology of frontonasal dysplasia. 日本先天異常学会学術集会プログラム・抄録集. 2019. 59th
山形和恒, 齋藤眞理子, 鈴木舞, 勝本拓夫, 小河穂波, 渡邊利雄, 北林一生. Supt6hとFACT complexは白血病関連因子AF10と結合し、MLL融合遺伝子白血病発症に寄与する(AF10 links histone chaperones Supt6h and FACT complex to MLL-fusion leukemia). 日本癌学会総会記事. 2018. 77回. 1936-1936

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Lectures and oral presentations (48)：

予後不良AMLの発症における脂質代謝制御因子SREBF1の役割の解析
(第82回日本癌学会学術総会 2023)
急性骨髄性白血病における脂質代謝経路の役割
(第27回造血器腫瘍研究会 2023)
脂質代謝による急性骨髄性白血病の制御
(第8回がんと代謝研究会 2022)
AF10 links histone chaperones Supt6h and FACT complex to MLL-fusion leukemia.
(2020)
ヒストンメチル化の脱制御は前頭鼻異形成の病因に関与する
(第59回日本先天性異常学術集会 2019)

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Education (4)：

Professional career (1)：

Awards (1)：

2018 - 国立がん研究センター研究所研究所所長賞 AF10 links histone chaperones Supt6h and FACT complex to MLL-fusion leukemia

Association Membership(s) (2)：

THE JAPANESE CANCER ASSOCIATION , THE MOLECULAR BIOLOGY SOCIETY OF JAPAN

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