Research theme for competitive and other funds (39):
2023 - 2026 Development toward ultra-early diagnosis and prevention of AD using specific antibody against the toxic conformation of amyloid β
2022 - 2025 細胞膜で多彩に機能する有機化合物の合成化学的開発
2019 - 2024 Very early diagnosis of Alzheimer's disease by the toxic oligomer specific antibody of amyloid beta
2017 - 2022 Frontiers in Chemical Communications
2017 - 2022 Unified comprehension of chemical communication by natural PKC ligands and development of new medicinal seeds
2016 - 2019 Abeta toxic conformer as a candidate of noble surrogate marker of Alzheimer disease
2014 - 2019 Novel Preventive Strategy for Alzheimer's Disease Based on the Toxic Conformation Theory of Amyloid beta
2015 - 2017 Investigation on antioxidants with low pro-oxidant activity to stabilize proteins responsible for neurodegenerative disease.
2011 - 2016 Chemical biology using natural products
2011 - 2016 Development and mechanistic analysis of new PKC ligands as anti-cancer agents
2012 - 2015 A new strategy for designing mannose receptors based on enantiomers of protein domains.
2012 - 2015 Search for Inhibitors of Amyloid beta Aggregation from Edible Plants and Their Mechanism
2009 - 2014 Development of medicinal seeds for Alzheimer's disease based on the structural analysis of toxic oligomers of amyloid beta
2011 - 2012 Search for novel PKC ligands as therapeutic seeds for intractable diseases
2008 - 2009 Analysis of the mechanism of the enzyme that catalyzes the introduction of the nitrogen atom into position 4 of the indole ring
2006 - 2008 Development of antibodies and aggregation inhibitors for amyloid β peptides based on the new aggregation model
2006 - 2007 CH/π相互作用を利用したPKCアイソザイム選択的な薬剤開発
2003 - 2006 Development of new agents that regulate cellular signal transduction
2005 - 2005 CH/π相互作用を利用したPKCδ選択的薬剤の創製
2005 - 2005 アミロイドβ42凝集体のターン構造をエピトープとしたワクチン療法の開発
2004 - 2005 Structural analysis of β-amyloid fibrils using solid-state NMR
2003 - 2004 質量分析法によるリガンド-レセプター相互作用の精密解析
2001 - 2003 Elucidation of aggregation mechanism of Alzheimer's β-peptides and development of their aggregation inhibitors
2001 - 2002 発がんプロモーションのメカニズム解明のための鍵化合物の開発と応用
2000 - 2000 発がんプロモーションのメカニズム解明のための鍵化合物の開発
1999 - 2000 Synthesis and characterization of the regulatory domains of protein kinase C
1996 - 1997 Synthesis and PKC binding of conformationally restricted indolactams by aza-Claisen rearrangement
1996 - 1996 発癌プロモーターとプロテインキナーゼCとの結合様式の有機化学的解析
1995 - 1995 新規水溶性フラーレン誘導体の合成とフォトダイナミックアクション
1995 - 1995 発癌プロモーターとプロテインキナーゼCとの結合様式の有機化学的解析
1994 - 1994 立体配座を固定した発癌プロモーター・テレオシジン誘導体の合成と生物活性
1994 - 1994 発癌プロモーターとプロテインキナーゼCとの結合様式の有機化学的解析
1993 - 1993 プロテインキナーゼCの光アフィニティーラベリング
1991 - 1992 Character and Application of the Cyclization Enzyme at position 4 of an indole ring.
1991 - 1991 新規クロロフィル誘導体のフォトダイナミックアクション
1990 - 1990 発癌プロモーター・インドラクタムVの生合成機構の解明と類縁体合成への応用
1988 - 1988 光親和性標識法による発癌プロモーターのレセプターの解析
1987 - 1987 蛍光標識発癌プロモーターの開発
1986 - 1986 生理活性インドールアルカロイド・テレオシジンの生合成に関する研究
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Papers (259):
Chihiro Tsukano, Ayumi Uchino, Kazuhiro Irie. Synthesis and applications of symmetric amino acid derivatives. Organic and Biomolecular Chemistry. 2024. 22. 3. 411-428
Ikuo Tooyama, Tomoko Kato, Hiroyasu Taguchi, Yusuke Kageyama, Kazuhiro Irie, Yukie Hirahara, Daijiro Yanagisawa. Visualization of Amyloid Oligomers in the Brain of Patients with Alzheimer’s Disease. Acta Histochemical et Cytochemica. 2023. 56. 6. 87-94
Yasuhiko Izumi, Harue Kataoka, Yuki Takada-Takatori, Yutaka Koyama, Kazuhiro Irie, Akinori Akaike, Toshiaki Kume. Isolation and Purification of Harpagogenin as an Nrf2-ARE Activator from the Tubers of Chinese Artichoke (Stachys sieboldii). Biological and Pharmaceutical Bulletin. 2023. 46. 11. 1576-1582
Kota Taniwa, Kazuma Murakami, Yoshiki Sakaguchi, Naotaka Izuo, Mizuho Hanaki, Nobuaki Sampa, Toshiaki Kume, Takahiko Shimizu, Kazuhiro Irie. Detection of Dietary Chalcone and Flavonoid Metabolites in Mice Using UPLC-MS/MS and Their Modulatory Effects on Amyloid β Aggregation. Journal of Agricultural and Food Chemistry. 2023. 71. 39. 14289-14299
Jumpei Maki, Yusuke Hanaki, Ryo C Yanagita, Masayuki Kikumori, Anastasiia Kovba, Ayaka Washizaki, Chihiro Tsukano, Hirofumi Akari, Kazuhiro Irie. Biological evaluation of a phosphate ester prodrug of 10-methyl-aplog-1, a simplified analog of aplysiatoxin, as a possible latency-reversing agent for HIV reactivation. Bioscience, Biotechnology, and Biochemistry. 2023. 87. 12. 1453-1461
Synthesis and characterization of dimer and trimer models of amyloid beta tethered at the C-terminal region
(6th International Symposium of Kyoto Biomolecular Mass Spectrometry Society (Doshisha University) 2023)
1982 - 1984 Kyoto University Graduate School of Agriculture Division of Food Science and Technology
1978 - 1982 Kyoto University Faculty of Agriculture Department of Food Science and Technology
Professional career (1):
Doctor of Agriculture (Kyoto University)
Work history (7):
2024/04 - 現在 Doshisha University Office for Research Initiatives and Development Researcher
2007/07 - 2024/03 京都大学 教授(農学研究科食品生物科学専攻)
2001/04 - 2007/06 京都大学 助教授(農学研究科食品生物科学専攻)
1999/04 - 2001/03 京都大学 助教授(農学研究科応用生命科学専攻)
1998/04 - 1999/03 京都大学 助手(農学研究科応用生命科学専攻)
1984/04 - 1997/03 京都大学 助手(農学部食品工学科)
1992/04 - 1993/03 米国スタンフォード大学化学科客員研究員(Paul A. Wender教授)
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Committee career (7):
2021/09 - 現在 日本認知症予防学会 基礎研究推進委員会 委員長
2009/09 - 現在 日本認知症学会 代議員
2021/05 - 2025/05 日本認知症予防学会 代議員
2021/05 - 2023/05 日本農芸化学会関西支部 支部長
2011/07 - 2014/03 日本学術振興会学術システム研究センター 研究員
2010/04 - 2012/03 日本農芸化学会 評議員
2008/04 - 2010/03 京都市医・工・ライフサイエンス連携プロジェクト検討委員会 委員
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Awards (6):
2023/03 - The Japan Society for Bioscience, Biotechnology, and Agrochemistry 2022年度 BBB Most-Cited Review Award New diagnostic method for Alzheimer’s disease based on the toxic conformation theory of amyloid β
2019/03 - Japan Society for Bioscience, Biotechnology, and Agrochemistry Japan Society for Bioscience, Biotechnology, and Agrochemistry Award in 2019 New prevention strategy for Alzheimer's disease based on the toxic conformation of amyloid β
2016/09 - 日本学術振興会 平成28年度科研費 審査委員表彰
2009/03 - The Excellent Paper Award Published in Bioscience, Biotechnology, & Biochemistry (2008) Verification of the Intermolecular Parallel β-Sheet in E22K-Aβ42 Aggregates by Solid-State NMR Using Rotational Resonance: Implications for the Supramolecular Arrangement of the Toxic Conformer of Aβ42
日本認知症予防学会
, 日本認知症学会
, The Japanese Peptide Society
, American Chemical Society
, Japan Society for Bioscience, Biotechnology, and Agrochemistry
, The Chemical Society of Japan
, Japanese Cancer Association