Rchr
J-GLOBAL ID：200901033602923766
Update date: Feb. 01, 2024
Kimura Minoru
キムラ ミノル | Kimura Minoru
Affiliation and department：
Job title：
Professor
Research field (3)：
Developmental biology
, Molecular biology
, Laboratory animal science
Research keywords (6)：
実験動物学
, 分子生物学
, 発生生物学
, Laboratory Animal Science
, Molecular Biology
, Developmental Biology
Research theme for competitive and other funds (65)：
- 2021 - 2024 遺伝子操作マウスを用いた神経障害エステラーゼの新規機能解明
- 2019 - 2024 多検体日本人口腔癌のエクソーム解析に基づく移植マウスモデルを用いた発がん機構解析
- 2019 - 2022 Expression characteristics of Sez12 gene, the murine homolog of DGCR2, in chondrocytes from 22q11.2 deletion syndrome model with knocked-in GFP
- 2017 - 2022 Development of comprehensive identification of spontaneous mutations based on whole genome sequencing applicable for the assessment of low-dose mutagens.
- 2016 - 2019 Establishment of assessment method for onset risk of sick house syndrome based on skin metabolism
- 2016 - 2019 Influences of stresses to motor learning
- 2016 - 2019 Elucidation of the mechanism of renal dysfunction improvement by Kampo treatment
- 2016 - 2019 The Sez12, mouse homolog of DGCR2 gene encoding within 22q11.2, contributes to enchondral ossification in skull base
- 2016 - 2019 Functional analysis of NOTCH1 variants
- 2015 - 2018 Oral cancer model of functional mutations in NOTCH1 and HRAS
- 2015 - 2018 Towards the diagnosis method for the toxicity of organophosphorus
- 2014 - 2017 Developing the Universal iPS cell lines using genetic engineering system
- 2013 - 2016 Molecular analysis of mast cell activation in mouse models for autoinflammatory syndromes and its use for anti-inflammatory drug development
- 2013 - 2016 Sez12 gene contributes to the chondrocytes differentiation by modulating TGF-ß signaling during postnatal maxillofacial development.
- 2012 - 2015 Analysis for the function of the candidate gene of Sick House Syndrome and development of disease model mouse
- 2010 - 2015 HLA genome diversity analyses by resequencing
- 2010 - 2014 Construction of molecular basis and clinical application of Kampo medicine
- 2010 - 2012 Analysis of the inflammatory mechanisms caused by the Ali18 mutation in molecular and cellular levels
- 2010 - 2012 Molecular analysis of craio-facial abnormalities found in the Sez12 knockout mice
- 2007 - 2009 Molecular pathology for functional differentiation of human pituitary adenomas : New development of NOTCH signaling pathway.
- 2007 - 2008 Sez12ノックアウトマウスを用いた顎形態形成に関する研究
- 2004 - 2006 Molecular pathology of the functional differentiation of the pituitary adenoma
- 2004 - 2005 ヒト少量血液からの対象ゲノム領域クローニング新手法の開発
- 2004 - 2005 疾患感受性ハプロタイプを検証する為の新規BACトランスジェニック手法の開発
- 2004 - 2005 Cytoplasmic polyadenylation and deadenylation of maternal RNAs from fully-grown oocyte to 2-cell embryo stages in the mouse
- 2003 - 2005 Research for the Cellular RNA Elongation in Mouse Fertilized Egg
- 2003 - 2004 マウス卵巣への効率的な遺伝子導入法の開発
- 2002 - 2004 Functional analysis of MHC class I molecules in the neuronal cells of central nervous
- 2000 - 2002 Development of Hybrid Bioartificial Tubules using Tubular Epithelial Cells
- 1999 - 2002 Production and analysis of transgenic mice exhibiting concentric hypertrophy in a heart using Cre-loxP system
- 2001 - 2001 受精後の初期発生プログラムに連動するポリA鎖伸長母性RNAの網羅的アプローチ
- 2000 - 2001 Studies on molecular genetic mechanism of intractable immune-mediated inflammatory diseases of the eye by genomic analyses
- 1999 - 2001 Cre-loxP系を応用した哺乳動物胚における新しい細胞系譜解析法の開発
- 1999 - 2001 Gene expression in early mouse embryo and its regulation
- 1999 - 2001 Identification of the genes for human diseases by the nucleotide analyses in wide range and developing the model mouse for them
- 2000 - 2000 マウス初期胚母性RNAの時期特異的ポリ(A)鎖伸長の意義
- 1999 - 1999 マウス初期胚発生における母性RNAのStage-specificな構造的変化
- 1998 - 1999 Mapping and cloning of the Da mutant gene defective dorsal-ventral patterning
- 1997 - 1999 個体への簡便で効率的な遺伝子導入法の確立
- 1998 - 1998 マウス初期胚における母性RNA情報の伝達と消長
- 1997 - 1997 マウス初期胚におけるmRNA情報の変化とその制御
- 1996 - 1997 ANALYSIS OF GENES EXPRESSED IN PREIMPLANTATION MOUSE EMBRYOS.
- 1995 - 1997 Analysis of Genes Expressed in.2 cell-stage.Mouse.Embryos.
- 1996 - 1996 標的遺伝子組換えによる突然変異体の作成とその生体機能の研究
- 1995 - 1996 Studies on cigarettes smoke carcinogenesis using trensgenic mouse with human c-Ha-ras gene contained somatically activated transgenes.
- 1995 - 1995 IL-12と癌ペプチドを用いた担癌生体内腫瘍特異的免疫の分子制御法の確立
- 1994 - 1994 腫瘍局所免疫(local help)の分子制御法の開発
- 1991 - 1993 相同組換え遺伝子導入による発癌機構の研究
- 1987 - 1992 外来遺伝子DNA導入による新しいモデル動物の開発
- 1991 - 1991 外来遺伝子DNA導入による新しいモデル動物の開発
- 1989 - 1991 導入オンコジ-ンの体細胞突然変異によって起こる個体発癌の研究
- 1990 - 1990 導入オンコジ-ンの体細胞突然変異誘発による個体発癌の研究
- 1988 - 1989 Analysis of gene function using transgenic mice harboring antisense DNA.
- 1988 - 1989 活性化オンコジーンを導入したトランスジェニックマウスによる個体発癌の研究
- 1987 - 1988 外来遺伝子DNA導入による新しいモデル動物の開発
- 1987 - 1988 活性化オンコジーンを導入したトランスジェニックマウスによる個体発癌の研究
- 1987 - 1987 遺伝子導入マウスにおける組織特異的遺伝子発現機構の研究
- 1987 - 1987 活性化オンコジーンを導入したトランスジェニックマウスによる個体発癌の研究
- 遺伝子操作マウスを用いた個体レベルでの遺伝子機能の解析
- 遺伝子改変マウスの開発
- ヒト疾患病態モデルマウスの開発
- マウス受精卵における遺伝子発現の調節
- Development of genetically-engineered mice
- Development of animal models for human diseases
- Regulation of Gene expression in early mouse embryo
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Papers (199)：
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Tomomi Hatanaka, Khampeeraphan Ramphai, Shun Takimoto, Hiromi Kanda, Nami Motosugi, Minoru Kimura, Tomotaka Mabuchi, Midori Oyama, Tomoharu Takeuchi, Yosuke Okamura. Potential UV-Protective Effect of Freestanding Biodegradable Nanosheet-Based Sunscreen Preparations in XPA-Deficient Mice. Pharmaceutics. 2022. 14. 2
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Yuko Osawa, Ken-Ichi Aoyama, Kazuyoshi Hosomichi, Masahiro Uchibori, Atsushi Tajima, Minoru Kimura, Yoshihide Ota. Somatic mutations in oral squamous cell carcinomas in 98 Japanese patients and their clinical implications. Cancer treatment and research communications. 2021. 29. 100456-100456
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Nami Motosugi, Chisa Okada, Akiko Sugiyama, Tomoyuki Kawasaki, Minoru Kimura, Takashi Shiina, Akihiro Umezawa, Hidenori Akutsu, Atsushi Fukuda. Deletion of lncRNA XACT does not change expression dosage of X-linked genes, but affects differentiation potential in hPSCs. Cell reports. 2021. 35. 10. 109222-109222
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Masahiro Uchibori, Yuko Osawa, Yuuki Ishii, Takayuki Aoki, Yoshihide Ota, Minoru Kimura. Analysis of HRAS mutations in Japanese patients with oral squamous cell carcinoma. Advances in Oral and Maxillofacial Surgery. 2021. 1. 100021-100021
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Kaori Masuhara, Hisako Akatsuka, Mizuki Tokusanai, Chenyang Li, Yumi Iida, Yoshinori Okada, Takahiro Suzuki, Masato Ohtsuka, Ituro Inoue, Minoru Kimura, et al. AMBRA1 controls antigen-driven activation and proliferation of naïve T cells. International immunology. 2020. 33. 2. 107-118
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MISC (137)：
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Quantitative Pain Evaluation Test for New Design of Microneedle. 2018. 53. 11. 802-807
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土肥颯一, 都田恒成, 梶原景正, 木村穣, 槌谷和義. 単一細胞用マイクロニードル型pHセンサの開発. 精密工学会大会学術講演会講演論文集. 2018. 2018. ROMBUNNO.H68
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赤塚尚子, 増原香織, 増原香織, 大塚正人, 井ノ上逸朗, 木村穰, 佐藤健人. AMBRA1はオートファジー非依存に細胞増殖制御に関与する. 日本分子生物学会年会プログラム・要旨集(Web). 2018. 41st
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内堀雅博, 内堀雅博, 太田嘉英, 青山謙一, 青山謙一, 梶原景正, 木村穣. 日本人口腔扁平上皮癌に見いだされた変異型NOTCH1分子の発現解析. 日本生化学会大会(Web). 2017. 90th. ROMBUNNO.1P-1000 (WEB ONLY)-1000]
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梶原景正, 渡部聡, 青山謙一, 内堀雅博, 斎藤雅幸, 弥栄聡介, 太田嘉英, 木村穰. 22q11.2欠失症候群の骨格異常に関するDGCR2のTGF-betaシグナル制御メカニズム. 日本生化学会大会(Web). 2017. 90th. ROMBUNNO.4LT10-04(3P-0438) (WEB ONLY)-04(3P
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Professional career (1)：
Association Membership(s) (5)：
日本遺伝学会
, 日本生化学会
, 日本実験動物学会
, 日本発生生物学会
, 日本分子生物学会
