Research theme for competitive and other funds (6):
2022 - 2026 Molecular mechanisms of the alteration of the bone marrow hematopoietic niche in leukemia and other diseases.
2022 - 2025 Establishment of interstitial literacy based on complex systems crosstalk
2022 - 2025 Investigation of the roles of stromal cell interactions in lung-bone marrow crosstalk
2019 - 2022 Gene regulatory network in cellular niches for hematopoietic stem cells
2016 - 2019 Dynamism and functions of niches for hematopoietic stem/progenitor cells in bone marrow
2011 - 2012 Molecular basis of hematopoietic stem and progenitor niche formation
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Papers (17):
Yoshiki Omatsu. Cellular niches for hematopoietic stem cells in bone marrow under normal and malignant conditions. Inflammation and Regeneration. 2023. 43. 1
Yoshiki Omatsu, Shota Aiba, Tomonori Maeta, Kei Higaki, Kazunari Aoki, Hitomi Watanabe, Gen Kondoh, Riko Nishimura, Shu Takeda, Ung-il Chung, et al. Runx1 and Runx2 inhibit fibrotic conversion of cellular niches for hematopoietic stem cells. Nature Communications. 2022. 13. 1
Toshinori Nakagawa, David J. Jörg, Hitomi Watanabe, Seiya Mizuno, Seungmin Han, Tatsuro Ikeda, Yoshiki Omatsu, Keiko Nishimura, Miyako Fujita, Satoru Takahashi, et al. A multistate stem cell dynamics maintains homeostasis in mouse spermatogenesis. Cell Reports. 2021. 37. 3. 109875-109875
Masanari Seike, Yoshiki Omatsu, Hitomi Watanabe, Gen Kondoh, Takashi Nagasawa. Stem cell niche-specific Ebf3 maintains the bone marrow cavity. Genes and Development. 2018. 32. 5-6. 359-372
Yoshiki Omatsu, Yoshiki Omatsu, Takashi Nagasawa. Identification of microenvironmental niches for hematopoietic stem cells and lymphoid progenitors-bone marrow fibroblastic reticular cells with salient features. International Immunology. 2021. 33. 12. 821-826
Yoshiki Omatsu, Yoshiki Omatsu, Kei Higaki, Takashi Nagasawa. Cellular Niches for Hematopoietic Stem Cells and Lympho-Hematopoiesis in Bone Marrow During Homeostasis and Blood Cancers. Current Topics in Microbiology and Immunology. 2021. 33-54