Rchr
J-GLOBAL ID：200901034013234450
Update date: Apr. 20, 2024
Sawa Hirofumi
サワ ヒロフミ | Sawa Hirofumi
Affiliation and department：
Job title：
Professor
Other affiliations (1)：
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University of Zambia
School of Veterinary Medicine
Visiting Professor
Homepage URL (1)：
http://www.czc.hokudai.ac.jp/pathobiol/
Research field (4)：
Molecular biology
, Experimental pathology
, Cell biology
, Virology
Research keywords (10)：
Vaccinology
, 感染症疫学
, モデルマウス
, 細胞内輸送
, ウイルス学
, animal model
, trafficking
, Cellular Biology
, Molecular Pathology
, Virology
Research theme for competitive and other funds (24)：
- 2022 - 2025 The role of MHC class I transactivator NLRC5 in COVID-19
- 2021 - 2024 VIrome analysis of bats in Indonesia
- 2016 - 2023 「ネオウイルス学」の国際活動支援
- 2021 - 2022 ネオウイルス学:生命の源流から超個体、そしてエコ・スフィアーへ
- 2016 - 2021 Comprehensive investigation and functional analysis of endogenous viruses and endogenous viral elements in hematophagous arthropods and their host animals
- 2016 - 2021 Neo-virology: the raison d'etre of viruses
- 2016 - 2020 Investigation of latent pathogenic viruses in Latin America and South-eastern Asia by virome analysis
- 2008 - 2011 Functional analysis of equine herpesvirus-1 receptor and its application for infection prevention
- 2007 - 2008 ウイルスを鋳型とした金属微粒子3次元規則配列構造の構築
- 2007 - 2008 Investigations for new pathogeneses of sudden deafness and Bell's palsy
- 2006 - 2007 Analysis of West Nile virus neuroinvasion using in vitro blood-brain barrier models
- 2004 - 2006 Investigation on the pathogenesis of herpetic facial nerve paralysis
- 2004 - 2006 Analysis of human synovial sarcoma oncoprotein SYT-SSX and its therapeutic application.
- 2003 - 2004 DNA damage checkpoint mechanism and its relation to aging
- 2002 - 2003 Molecular investigation on prognostic factors and development of an tailor-made therapy for Hunt syndrome.
- 1999 - 2003 女性性殖器官に特異的な新規マトリックスメタロプロテアーゼMIFRの機能解析
- 2001 - 2002 Analysis of transforming mechanism of human synovial sarcoma oncogene SYT-SSX
- 2000 - 2001 Investigation on the pathogenesis of acute peripheral facial palsy caused by herpes simplex virus reactivation.
- 2000 - 2001 The preventive effects of angiotensin II receptor blocker on lethal ventricular arrhythmias, a leading cause of sudden cardiac death, in experimental failing animal hearts
- 1999 - 2000 Investigation on CDDP resistance of Head and Neck Cancer.
- 1998 - 2000 Analysis of mechanisms of demyelination in progressive multifocal leukoencephalopathy
- 1997 - 1999 血管内皮成長因子(VEGF)を併用した虚血心筋再潅流の研究
- 1997 - 1999 Analysis of apoptotic mechanism of cerebellar granular cells
- 1996 - 1997 Yeast One Hybrid法によるJC virus複製機構の検討
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Papers (499)：
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Kosuke Takada, Yasuko Orba, Yurie Kida, Jiaqi Wu, Chikako Ono, Yoshiharu Matsuura, So Nakagawa, Hirofumi Sawa, Tokiko Watanabe. Genes involved in the limited spread of SARS-CoV-2 in the lower respiratory airways of hamsters may be associated with adaptive evolution. Journal of virology. 2024. e0178423
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Takuma Ariizumi, Koshiro Tabata, Yukari Itakura, Hiroko Kobayashi, William W Hall, Michihito Sasaki, Hirofumi Sawa, Keita Matsuno, Yasuko Orba. Establishment of a lethal mouse model of emerging tick-borne orthonairovirus infections. PLoS pathogens. 2024. 20. 3. e1012101
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Chimuka Handabile, Marumi Ohno, Toshiki Sekiya, Naoki Nomura, Tomomi Kawakita, Mamiko Kawahara, Masafumi Endo, Tomohiro Nishimura, Minako Okumura, Shinsuke Toba, et al. Immunogenicity and protective efficacy of a co-formulated two-in-one inactivated whole virus particle COVID-19/influenza vaccine. Scientific reports. 2024. 14. 1. 4204-4204
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Michihito Sasaki, Tatsuki Sugi, Shun Iida, Yuichiro Hirata, Shinji Kusakabe, Kei Konishi, Yukari Itakura, Koshiro Tabata, Mai Kishimoto, Hiroko Kobayashi, et al. Combination therapy with oral antiviral and anti-inflammatory drugs improves the efficacy of delayed treatment in a COVID-19 hamster model. EBioMedicine. 2023. 99. 104950-104950
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Takuya Tsumita, Ryo Takeda, Nako Maishi, Yasuhiro Hida, Michihito Sasaki, Yasuko Orba, Akihiko Sato, Shinsuke Toba, Wataru Ito, Takahito Teshirogi, et al. Viral uptake and pathophysiology of the lung endothelial cells in age-associated severe SARS-CoV-2 infection models. Aging Cell. 2023. e14050
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MISC (206)：
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佐々木道仁, 杉達紀, 飯田俊, 平田雄一郎, 日下部伸治, 日下部伸治, 小西慧, 小西慧, 板倉友香里, 板倉友香里, et al. Combination therapy with oral antiviral and anti-inflammatory treatments improves the delayed-therapeutic effect on COVID-19. 日本ウイルス学会学術集会プログラム・予稿集(Web). 2023. 70th
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岸本麻衣, 岸本麻衣, 梶原将大, 高田礼人, 大園誠也, 鈴木忠樹, 伊藤直人, 大場靖子, 澤洋文, 澤洋文, et al. ザンビアのエジプトルーセットオオコウモリおよびマストミスから分離されたロタウイルスAの性状解析. 日本獣医学会学術集会講演要旨集. 2023. 166th
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高田光輔, 大場靖子, 木田裕里恵, 呉佳齊, 小野慎子, 小野慎子, 松浦善治, 松浦善治, 中川草, 澤洋文, et al. Genes involved in spread of SARS-CoV-2 into the lower respiratory tract may be under adaptive selection. 日本進化学会大会プログラム・講演要旨集(Web). 2023. 25th
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日野谷 直人, 中村 元紀, 田良島 典子, 大場 靖子, 澤 洋文, 松田 彰, 前仲 勝実, 南川 典昭. 5-Ethynylimidazole-4-carboxamide(EICA)ヌクレオチドプロドラッグの合成と抗デングウイルス活性. 日本薬学会年会要旨集. 2022. 142年会. 28S-pm03S
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武田遼, 武田遼, 伊藤航, 手代木孝仁, 佐々木道仁, 大場靖子, 大場靖子, 間石奈湖, 松田彩, 佐藤彰彦, et al. SARS-CoV-2感染マウスを用いた肺血管内皮細胞の重症化関連遺伝子の解析. 日本血管生物医学会学術集会プログラム・抄録集. 2022. 30th (CD-ROM)
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Patents (2)：
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JCウイルスのVP-1に対するsiRNA、およびそれを含有してなる医薬組成物
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JCウイルスagnoを対象としたPMLの治療
Books (6)：
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プリオン病と遅発性ウイルス感染症
金原出版 2010
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Molecular Biology of Tumor Virus Gene Products.
Research Signpost 2009
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DNA viruses, Methods and Protocols.
Humana Press 2005
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Understanding of Minamata disease. Methylmercury poisoning in Minamata and Niigata, Japan
Japan Public Health Association 2001
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Endokrine und zellbiologische aspekte der arteriosklerose 10
Jahrestagung der Deutschen Gesellschaft für Arterioskleroseforschung 1996
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Professional career (1)：
Work history (3)：
- 2023/04 - 現在 Hokkaido University Institute for Vaccine Research and Development: HU-IVReD Professor
- 2021/04 - 2023/03 international institute for Zoonosis Control, Hokkaido University Division of Molecular pathobiology professor
- 2005/04 - 2021/03 Research center for Zoonosis Control, Hokkaido University Division of Molecular Pathobiology Profesor
Awards (1)：
- 2016/02 - Hokkaido University Hokkaido University Presidential Commendation for Education and Research Excellence Award
Association Membership(s) (9)：
Global Virus network
, 分子生物学会
, 日本病理学会
, 日本内科学会
, 日本生化学会
, 日本神経病理学会
, 日本循環器学会
, 日本ウイルス学会
, American Society of MicrobiologyAmerican Society for Biochemistry and Molecular BiologyInternational Society for Neurovirology
