Rchr
J-GLOBAL ID:200901034420320345   Update date: Feb. 02, 2024

Asada Hidetsugu

Asada Hidetsugu
Affiliation and department:
Job title: 特定講師
Research field  (3): Immunology ,  Molecular biology ,  Structural biochemistry
Research keywords  (2): GPCR ,  structural biology
Research theme for competitive and other funds  (8):
  • 2022 - 2026 グレリン受容体のシグナル伝達選択機構の構造基盤
  • 2018 - 2021 X線自由電子レーザーによるGタンパク質共役型受容体の活性化機構の解明
  • 2013 - 2015 ヒトアンジオテンシン受容体の構造情報に基づく血圧調節機構の理解から創薬へ
  • 2012 - 2015 次世代抗ヒスタミン薬の開発に役立つヒスタミン受容体の構造解析
  • 2011 - 2012 活性型GPCRの構造解析への挑戦
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Papers (50):
  • Tsuyoshi Araya, Yuya Matsuba, Harufumi Suzuki, Tomohiro Doura, Nipawan Nuemket, Eriko Nango, Masaki Yamamoto, Dohyun Im, Hidetsugu Asada, Shigeki Kiyonaka, et al. Crystal structure reveals the binding mode and selectivity of a photoswitchable ligand for the adenosine A2A receptor. Biochemical and biophysical research communications. 2024. 695. 149393-149393
  • Dohyun Im, Jun-Ichi Kishikawa, Yuki Shiimura, Hiromi Hisano, Akane Ito, Yoko Fujita-Fujiharu, Yukihiko Sugita, Takeshi Noda, Takayuki Kato, Hidetsugu Asada, et al. Structural insights into the agonists binding and receptor selectivity of human histamine H4 receptor. Nature communications. 2023. 14. 1. 6538-6538
  • Hidetsugu Asada, Dohyun Im, Yunhon Hotta, Satoshi Yasuda, Takeshi Murata, Ryoji Suno, So Iwata. Molecular basis for anti-insomnia drug design from structure of lemborexant-bound orexin 2 receptor. Structure (London, England : 1993). 2022. 30. 12. 1582-1589
  • Shintaro Maeda, Yuki Shiimura, Hidetsugu Asada, Kunio Hirata, Fangjia Luo, Eriko Nango, Nobuo Tanaka, Masayasu Toyomoto, Asuka Inoue, Junken Aoki, et al. Endogenous agonist-bound S1PR3 structure reveals determinants of G protein-subtype bias. Science advances. 2021. 7. 24
  • Dohyun Im, Asuka Inoue, Takaaki Fujiwara, Takanori Nakane, Yasuaki Yamanaka, Tomoko Uemura, Chihiro Mori, Yuki Shiimura, Kanako Terakado Kimura, Hidetsugu Asada, et al. Structure of the dopamine D2 receptor in complex with the antipsychotic drug spiperone. Nature Communications. 2020. 11. 1
more...
MISC (15):
Patents (2):
Books (3):
  • Muscarinic Receptor: From Structure to Animal Models
    Humana Press 2016
  • 膜タンパク質構造研究
    株式会社化学同人 2013
  • 別冊・医学のあゆみ 免疫疾患 state of arts Ver.2
    医歯薬出版株式会社 2002
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