Rchr
J-GLOBAL ID：200901034663759310
Update date: Mar. 01, 2024
Mizukami Hiroaki
ミズカミ ヒロアキ | Mizukami Hiroaki
Affiliation and department：
Homepage URL (1)：
http://www.jichi.ac.jp/idenshi/index.html
Research field (1)：
Internal medicine - General
Research keywords (6)：
分子生物学
, ウィルス学
, 血液内科学
, Molecular Biology
, Virology
, Hematology
Research theme for competitive and other funds (29)：
- 2023 - 2026 Development of novel therapy targeting microRNA for peritoneal dissemination and elucidation of its immunological mechanism
- 2022 - 2025 甲状腺未分化癌に対する脱メチル化遺伝子治療の基礎研究
- 2022 - 2025 Development of Plasmodium vivax vaccine effective both for protection and transmission blocking
- 2020 - 2023 頭頸部癌に対するソマトスタチン受容体の遺伝子導入と新規分子標的治療
- 2020 - 2023 TET2遺伝子を用いた膠芽腫に対するマルチターゲット脱メチル化遺伝子治療研究
- 2017 - 2021 Development of novel gene therapy for head and neck cancer applying demethylation mechanism
- 2014 - 2017 Molecular Targeted Therapy Utilizing Galanin receptor type 2 signaling for Head and Neck Cancer
- 2013 - 2016 Development of gene therapy approaches towards hemophilia A
- 2011 - 2013 Preclinical study for Head and Neck Cancer using rAAV-GALR2
- 2010 - 2012 Gene Therapy for Head and Neck Cancer using Adeno-Associated Virus Vector Harboring Galanin Receptor type1
- 2009 - 2011 Improvement of neutralizing antibody assay against AAV vectors and application to hemophilia gene therapy
- 2005 - 2009 Development of AAV (adeno-associated virus) vectors and their application to cancer therapy
- 2007 - 2008 Tissue specificity and utility of AAV vectors in hemophilia gene therapy
- 2005 - 2007 Gene therapy targeting lipid mediators for prevention of bone destruction
- 2005 - 2006 新生児期遺伝子治療におけるアデノ随伴ウイルスベクターの体内動態と治療効果
- 2005 - 2006 Optimization of gene transfer conditions to adipose tissue and application toward hemophilia
- 2004 - 2005 DEDIFFERENTIATION OF NON-HEMATOPOIETIC TISSUE BY GENETIC MANIPULATION AND ITS ACQUISITION OF PLASTICITY AND HEMATOPOIETIC TRANSDIFFERENTIATION
- 2003 - 2004 AAV-mediated bone gene therapy targeting nitric oxide synthase
- 2003 - 2004 Optimization of gene therapy approaches for hemophilia
- 2003 - 2004 アデノ随伴ウイルス(AAV)ベクターの開発とその癌遺伝子治療への応用
- 2002 - 2003 Gene therapy for Alzheimer's disease by viral vector-mediated neprilysin, an Aβ-degrading enzyme, gene transfer
- 2002 - 2003 Development of basic technologies for gene therapy using adeno-associated virus (AAV)
- 2001 - 2002 Gene therapy for hemophilia A with simian immunodeficiency virus agmTYO1-based vectors carrying human factor VIII gene.
- 2000 - 2001 Fundamental researches toward gene therapy of Hemophilia A utilizing adeno-associated virus vectors
- 2000 - 2001 Development of the gene therapy technologies using adeno-associated virus (AAV)
- 1999 - 2001 Gene transfer into hematopoietic stem cells and gene therapy for chronic granulomatous disease
- 2000 - 2000 AAVベクターによる抗腫瘍血管療法と新規アデノ-AAVハイブリッドベクターの開発
- 1. 遺伝子導入に関連する分子基盤とin vivoにおける組織特異性の解明 2. AAV各血清型に由来するベクターの特性の解明 3. 導入遺伝子産物に対する免疫反応の解析とその制御 4. ベクターに対する免疫反応が遺伝子導入に与える影響の解析 5. 血友病・悪性腫瘍・神経疾患などに対する新規治療法の開発
- Gene transfer
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Papers (184)：
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Yuka Hayashi, Yoshihide Sehara, Ryota Watano, Kenji Ohba, Yuki Takayanagi, Yoshio Sakiyama, Kazuhiro Muramatsu, Hiroaki Mizukami. Therapeutic strategy for Fabry disease by intravenous administration of adeno-associated virus 9 in a symptomatic mouse model. Human Gene Therapy. 2024
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Keitaro Obara, Teppei Ebina, Shin-Ichiro Terada, Takanori Uka, Misako Komatsu, Masafumi Takaji, Akiya Watakabe, Kenta Kobayashi, Yoshito Masamizu, Hiroaki Mizukami, et al. Change detection in the primate auditory cortex through feedback of prediction error signals. Nature Communications. 2023. 14. 1
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Kenta Fujimura, Tadayoshi Karasawa, Takanori Komada, Naoya Yamada, Yoshiko Mizushina, Chintogtokh Baatarjav, Takayoshi Matsumura, Kinya Otsu, Norihiko Takeda, Hiroaki Mizukami, et al. NLRP3 inflammasome-driven IL-1β and IL-18 contribute to lipopolysaccharide-induced septic cardiomyopathy. Journal of molecular and cellular cardiology. 2023. 180. 58-68
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Yuka Hayashi, Yoshihide Sehara, Ryota Watano, Kenji Ohba, Yuki Takayanagi, Kazuhiro Muramatsu, Yoshio Sakiyama, Hiroaki Mizukami. Therapeutic strategy for Fabry disease by intravenous administration of adeno-associated virus 2 or 9 in α-galactosidase A-deficient mice. The journal of gene medicine. 2023. e3560
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Akiya Watakabe, Henrik Skibbe, Ken Nakae, Hiroshi Abe, Noritaka Ichinohe, Muhammad Febrian Rachmadi, Jian Wang, Masafumi Takaji, Hiroaki Mizukami, Alexander Woodward, et al. Local and long-distance organization of prefrontal cortex circuits in the marmoset brain. Neuron. 2023. 111. 14. 2258-2273
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MISC (168)：
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T. Yoshiba, Y. Saga, Y. Sehara, R. Uchibori, M. Urabe, H. Fujiwara, S. Matsubara, H. Mizukami. Efficient targeting of uterine cervical cancer using AAV vectors encoding CRISPR/Cas9 against HPV-E6 gene. HUMAN GENE THERAPY. 2017. 28. 12. A24-A25
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K. Kojima, A. Miyauchi, T. Nakajima, N. Taga, S. A. Ono, H. Mizukami, M. Kato, H. Osaka, S. Muramatsu, T. Yamagata. Gradual improvements in the motor and cognitive function after gene therapy for patients with AADC deficiency. HUMAN GENE THERAPY. 2017. 28. 12. A4-A4
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Ryosuke Uchibori, Ken Ohmine, Yoshihide Sehara, Masashi Urabe, Hiroaki Mizukami, Junichi Mineno, Kazuto Takesako, Keiya Ozawa. Effect of CAR-T Therapy on Bone Lesions in Myeloma Mouse Model. MOLECULAR THERAPY. 2017. 25. 5. 58-58
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K. Kojima, A. Miyauchi, T. Nakajima, S. A. Ono, H. Mizukami, M. Kato, H. Osaka, S. Muramatsu, T. Yamagata. Continuous improvement of motor, autonomic, and cognitive functions following gene therapy for AADC deficiency. HUMAN GENE THERAPY. 2016. 27. 11. A146-A147
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T. Yamagata, K. Kojima, A. Miyauchi, T. Nakajima, S. A. Ono, H. Mizukami, K. Ozawa, T. Sato, M. Kato, H. Osaka, et al. Improvements in motor function and PET findings following gene transfer to the patients with AADC deficiency. HUMAN GENE THERAPY. 2016. 27. 11. A45-A45
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Patents (2)：
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組換えアデノ随伴ウイルスを含むマラリアワクチン
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肝臓ゲノム上の凝固関連因子遺伝子を破壊するためのAAVベクター
Books (1)：
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『糖尿病学ー基礎と臨床』
西村書店 2007 ISBN:9784890133550
Education (1)：
Professional career (2)：
Work history (11)：
- 2014 - 現在 同 教授
- 2011 - 2014 同 准教授
- 2004 - 2011 同 講師
- 1998 - 2003 Jichi Medical University
- 1995 - 1998 Chief academic administrater. school for
- 1993 - 1995 米国国立保健研究所 客員研究員
- 1993 - 1995 National Institutes of Health, Visiting
- 1988 - 1990 潜水医学実験隊(防衛庁)実験部員
- emergency medical corp. JSDF Hospital Yokosuka
- Associate
- Jichi Medical University Professor
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Committee career (5)：
- 2012 - 現在 日本ウイルス学会 評議員
- 2003 - 日本遺伝子治療学会 評議員
- 欧州遺伝子細胞治療学会 会員
- 日本癌学会 評議員
- 米国遺伝子治療学会 会員
Association Membership(s) (7)：
欧州遺伝子細胞治療学会
, 日本癌学会
, 米国遺伝子治療学会
, 日本ウィルス学会
, 日本遺伝子治療学会
, 日本血液学会
, 日本内科学会
