Research field (2)：
Pharmacology
, Neuroscience - general
Research keywords (6)：
neuronal protection
, プリン体
, glutathione
, bone marrow mesenchymal stem cell
, neurodegenerative disease
, microRNA
Papers (18)：
Nobuko Matsumura, Chisato Kinoshita, Wattanaporn Bhadhprasit, Toshio Nakaki, Koji Aoyama. A purine derivative, paraxanthine, promotes cysteine uptake for glutathione synthesis. Journal of pharmacological sciences. 2023. 151. 1. 37-45
Chisato Kinoshita, Kazue Kikuchi-Utsumi, Koji Aoyama, Ryo Suzuki, Yayoi Okamoto, Nobuko Matsumura, Daiki Omata, Kazuo Maruyama, Toshio Nakaki. Inhibition of miR-96-5p in the mouse brain increases glutathione levels by altering NOVA1 expression. Communications biology. 2021. 4. 1. 182-182
Nobuko Matsumura, Chisato Kinoshita, Koji Aoyama. Mechanism of glutathione production in neurons. Folia Pharmacologica Japonica. 2021. 156. 1. 26-30
Aoyama K, Bhadhprasit W, Watabe M, Wang F, Matsumura N, Nakaki T. GTRAP3-18 regulates food intake and body weight by interacting with pro-opiomelanocortin. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2017. 32. 1. 330-341
Nobuko Matsumura, Toshio Nakaki. Isobolographic analysis of the mechanisms of action of anticonvulsants from a combination effect. EUROPEAN JOURNAL OF PHARMACOLOGY. 2014. 741. 237-246
N Matsumura, M Okanaga, T Nakaki. Involvement of brain arginine increase in glufosinate ammonium-induced delayed convulsion. JOURNAL OF PHARMACOLOGICAL SCIENCES. 2005. 97. 260P-260P
N Matsumura, M Ishizaka, T Nakaki. Mechanisms underlying glufosinate-ammonium-induced delayed convulsion. JOURNAL OF PHARMACOLOGICAL SCIENCES. 2004. 94. 166P-166P
N Matsumura, M Ishizaka, K Hishikawa, T Fujii, T Nakaki. Decrease in brain glutamate content during glufosinate ammonium-induced convulsion in mouse. JOURNAL OF PHARMACOLOGICAL SCIENCES. 2003. 91. 204P-204P
Lectures and oral presentations (48)：
Regulations of cysteine uptake and intracellular glutathione levels by purine derivatives
(The 96th Annual Meeting of the Japanese Pharmacological Society 2022)
The effect of a miR-96-5p inhibitor delivery to brain using microbubbles and ultrasound technology on neuroprotection and autophagy activation
(2022)
Promotion of cysteine-dependent glutathione synthesis by paraxanthine
(2022)
Increased glutathione via NOVA1 by administration of an inhibitor of the microRNA miR-96-5p
(Proceedings for Annual Meeting of The Japanese Pharmacological Society 2021)
The development of miR-96-5p gene knock out technique by CRISPR/Cas9 system
(Proceedings for Annual Meeting of The Japanese Pharmacological Society 2021)
