Rchr
J-GLOBAL ID：200901035213058114
Update date: Feb. 29, 2024
Akita Hirotoshi
アキタ ヒロトシ | Akita Hirotoshi
Affiliation and department：
Job title：
Specially Appointed Professor
Research field (3)：
Hematology and oncology
, Tumor diagnostics and therapeutics
, Respiratory medicine
Research keywords (2)：
腫瘍内科学
, Medical Oncology
Research theme for competitive and other funds (26)：
- 2017 - 2020 Significance of genetic alterations and glycosylation in PD-L1 and their biomarker development
- 2014 - 2017 Combined inhibition of stem cell markers and histone modification enzymes in non-small cell lung cancer
- 2014 - 2016 Study on EGFR-TKI resistance using FRET biosensor
- 2012 - 2015 Studies focused on discovery of micro RNA function for biomarkers in chemotherapy against lung cancer
- 2010 - 2012 Alteration of fucosylation and biomarker development in lung cancer
- 2008 - 2010 Identification of novel molecular targets for lung cancer based on different sensitivity to AP-1 blockade
- 2006 - 2007 肺癌および随伴肺疾患における糖転移酵素の発現異常に関する研究
- 2006 - 2007 タイプ免疫活性化を介した肺ガン治療に対する放射線治療の併用増強効果
- 2005 - 2006 Phase I clinical trial of cancer vaccine using adjuvant for activation of immunity
- 2003 - 2004 Cellular immunotherapy and immune-gene therapy by heat shock protein gp96 and dendritic cells
- 2001 - 2002 Immuno-gene therapy by secreted gp96-Ig fusion protein
- 2002 - 肺癌の治療標的探索と診断マーカー・層別化マーカー開発に関する研究
- 1999 - 2000 Altered Expression of Cell Cycle-Regulatory Tumor Suppressor Proteins in Neuroendocrine Lung tumors : Their Significance for the Differential Diagnosis
- 2000 - 癌における糖転移酵素の発現異常の臨床的・生物学的意義に関する研究
- 2000 - biological and clinical significance of altered expression of GnT-V and GalNAc-T3 in human cancers
- 1997 - 1999 Study for the Development of Therapy Based on the Regulation of the myc Gene Expression in Lung Cancer
- 1996 - 1997 Therapy of Lung Cancer Based on the Regulation of Gene Expression
- 1993 - 1994 Basic Study for The Gene-Targeted Therapy in Lung cancer
- 1990 - 1993 Studies on The Expression of Genes during Lung Development and Differentiation
- 1991 - 1992 Biological Function of Retinoic Acid Receptors in Bronchopulmonary System
- 肺癌におけるRB,p16INK4発現異常の意義
- 癌のアンチセンス治療に関する研究
- 肺癌における遺伝子異常の研究
- Altered Expression of RB and p16INK4 in lung cancer
- Study on the antisense therapy in cancer
- Study on the genetic abnormality in Lung Cancer
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Papers (304)：
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Satoshi Takeuchi, Kenji Hirata, Keiichi Magota, Shiro Watanabe, Rika Moku, Akihiko Shiiya, Jun Taguchi, Shin Ariga, Tomohiro Goda, Yoshihito Ohhara, et al. Early prediction of treatment outcome for lenvatinib using 18F-FDG PET/CT in patients with unresectable or advanced thyroid carcinoma refractory to radioiodine treatment: a prospective, multicentre, non-randomised study. EJNMMI research. 2023. 13. 1. 69-69
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Kanako Hagio, Junko Kikuchi, Kohichi Takada, Hiroki Tanabe, Minako Sugiyama, Yoshihito Ohhara, Toraji Amano, Satoshi Yuki, Yoshito Komatsu, Takahiro Osawa, et al. Assessment for the timing of comprehensive genomic profiling tests in patients with advanced solid cancers. Cancer science. 2023
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Daisuke Morinaga, Hajime Asahina, Shotaro Ito, Osamu Honjo, Hisashi Tanaka, Ryoichi Honda, Hiroshi Yokouchi, Keiichi Nakamura, Kei Takamura, Fumihiro Hommura, et al. Real-world data on the efficacy and safety of immune-checkpoint inhibitors in elderly patients with non-small cell lung cancer. Cancer medicine. 2023
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Osamu Taniguchi, Yoshitaka Saito, Yoh Takekuma, Hirotoshi Akita, Ichiro Kinoshita, Yasushi Shimizu, Naofumi Shinagawa, Mitsuru Sugawara. Efficacy of antacids for cisplatin-induced gastrointestinal symptoms in the treatment of lung cancer. International journal of clinical pharmacology and therapeutics. 2023. 61. 6. 246-254
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椎谷 研彦, 野口 卓郎, 外丸 詩野, 有賀 伸, 高島 雄太, 品川 尚文, 木下 一郎, 松野 吉宏, 榊原 純, 秋田 弘俊. EGFR変異陽性肺癌におけるCD24発現の検討. 日本病理学会会誌. 2023. 112. 1. 247-247
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MISC (508)：
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Ikuo Sekine, Yasushi Shintani, Takehito Shukuya, Koichi Takayama, Akira Inoue, Isamu Okamoto, Katsuyuki Kiura, Kazuhisa Takahashi, Hirotoshi Dosaka-Akita, Yuichi Takiguchi, et al. A Japanese lung cancer registry study on demographics and treatment modalities in medically treated patients (vol 111, pg 1685, 2020). CANCER SCIENCE. 2021. 112. 3. 1332-1332
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原田敏之, 大泉聡史, 高村圭, 立原素子, 森川直人, 本田亮一, 渡部聡, 朝尾哲彦, 國崎守, 福原達朗, et al. Phase II study of carboplatin-paclitaxel alone or with bevacizumab in advanced sarcomatoid carcinoma of the lung: HOT1201/NEJ024. 日本呼吸器学会誌(Web). 2021. 10
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Shin-ichi Fukumoto, Satoshi Oizumi, Masao Harada, Noriaki Sukoh, Kosuke Nakano, Satoshi Fuke, Jun Sakakibara-Konishi, Kei Takamura, Kenichiro Ito, Yuka Fujita, et al. A randomized phase II trial of cisplatin plus gemcitabine versus carboplatin plus gemcitabine in patients with completely resected non-small cell lung cancer: Hokkaido Lung Cancer Clinical Study Group Trial (HOT0703). Cancer Chemotherapy and Pharmacology. 2020. 86. 1. 117-127
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木下 一郎, 加納 里志, 清田 尚臣, 多田 雄一郎, 伊地知 圭, 山崎 知子, 西本 尚樹, 畑中 豊, 松野 吉弘, 秋田 弘俊. HER2陽性再発・転移唾液腺癌患者に対するトラスツズマブ・ドセタキセル併用療法の第II相試験. 日本内科学会雑誌. 2020. 109. Suppl. 230-230
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Junichi Shimizu, Katsuhiro Masago, Haruhiro Saito, Kazumi Nishino, Takayasu Kurata, Yohji Itoh, Yoko Yoshimura, Yutaka Yabuki, Hirotoshi Dosaka-Akita. Biomarker testing for personalized, first-line therapy in advanced nonsquamous non-small cell lung cancer patients in the real world setting in Japan: a retrospective, multicenter, observational study (the BRAVE study). Therapeutic Advances in Medical Oncology. 2020. 12. 175883592090452-175883592090452
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Books (7)：
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新臨床腫瘍学 改訂第5版(がん薬物療法専門医のために)
南江堂 2018
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細胞周期の制御
呼吸器疾患の分子生物学 1998
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肺癌
呼吸器疾患の分子生物学 1998
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肺癌の分子生物学
最新内科学大系プログレス11 1997
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Current Review 今日の癌化学療法
中外医学社 1996
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Lectures and oral presentations (13)：
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「がんゲノム医療の現状と今後の方向性-薬剤師への期待-」
(日本臨床腫瘍薬学会学術大会2019 2019)
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がんゲノム医療に関する最新情報
(佐賀県呼吸器学術講演会 2019)
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北海道大学病院のゲノム医療
(3rd Medical Cluster City Sapporo FORUM 2018)
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ゲノム医療の提供体制~中核拠点病院と連携病院の関わり~
(第59回日本肺癌学会学術集会 2018)
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肺癌プレシジョンメディシン:現状と展望
(第57回日本臨床細胞学会秋期大会 2018)
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Education (4)：
- - 1987 Hokkaido University
- - 1987 Hokkaido University Graduate School, Division of Medicine
- - 1981 Hokkaido University School of Medicine
- - 1981 Hokkaido University Faculty of Medicine
Professional career (1)：
- (BLANK) (Hokkaido University)
Committee career (7)：
Awards (4)：
- 2022/02 - 北海道科学技術賞
- 2015/10 - 北海道知事賞
- 2015/10 - 北海道医師会賞
- 1995/10 - 日本肺癌学会篠井・河井賞
Association Membership(s) (13)：
日本臨床腫瘍学会
, アメリカ臨床腫瘍学会
, 世界肺癌学会
, アメリカ癌学会
, 日本臨床細胞学会
, 日本癌治療学会
, 日本肺癌学会
, 日本癌学会
, 日本呼吸器学会
, 日本内科学会
, IASLC
, ASCO
, AACR
