MUKAI ERI

ムカイエリ | MUKAI ERI

Affiliation and department：
Job title： Professor

Research field (4)： Metabolism and endocrinology , Pathobiochemistry , Clinical pharmacy , Physiology

Research keywords (1)： life style related disease, physiology, metabology, diabetes, hormone

Research theme for competitive and other funds (7)：

2022 - 2025 効果的な妬み緩和マネジメントに関する検討:多面的計測による介入対処策の提案
2021 - 2024 糖尿病膵β細胞糖代謝変換における一次繊毛ヘッジホッグシグナルの重要性
2016 - 2019 The role of primary cilia on cell to cell communication in pancreatic islets
2013 - 2016 Functional regulation of pancreatic islets by cell to cell communication
2013 - 2016 Crosstalk between fat metabolism and insulin signaling in glucose homeostasis: Analysis in fat-sensitive diabetes mice

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Papers (61)：

Takumi Shimada, Fumihiro Kato, Dinia Rizqi Dwijayanti, Takuma Nagata, Akito Kinoshita, Tetsuya Okuyama, Mikio Nishizawa, Eri Mukai. Bitter melon fruit extract enhances intracellular ATP production and insulin secretion from rat pancreatic β-cells. The British journal of nutrition. 2022. 127. 3. 377-383
Yu Ogawa, Hiroyuki Kimura, Hiroyuki Fujimoto, Hidekazu Kawashima, Kentaro Toyoda, Eri Mukai, Yusuke Yagi, Masahiro Ono, Nobuya Inagaki, Hideo Saji. Development of novel radioiodinated exendin-4 derivatives targeting GLP-1 receptor for detection of β-cell mass. Bioorganic & medicinal chemistry. 2021. 52. 116496-116496
Hisato Tatsuoka, Satoko Sakamoto, Daisuke Yabe, Ryotaro Kabai, Unyanee Kato, Tatsuya Okumura, Ainur Botagarova, Shinsuke Tokumoto, Ryota Usui, Masahito Ogura, et al. Single-Cell Transcriptome Analysis Dissects the Replicating Process of Pancreatic Beta Cells in Partial Pancreatectomy Model. iScience. 2020. 23. 12. 101774-101774
Dinia R Dwijayanti, Takumi Shimada, Toshinari Ishii, Tetsuya Okuyama, Yukinobu Ikeya, Eri Mukai, Mikio Nishizawa. Bitter melon fruit extract has a hypoglycemic effect and reduces hepatic lipid accumulation in ob/ob mice. Phytotherapy research : PTR. 2020. 34. 6. 1338-1346
Hiroyuki Kimura, Yu Ogawa, Hiroyuki Fujimoto, Eri Mukai, Hidekazu Kawashima, Kenji Arimitsu, Kentaro Toyoda, Naotaka Fujita, Yusuke Yagi, Keita Hamamatsu, et al. Evaluation of 18F-labeled exendin(9-39) derivatives targeting glucagon-like peptide-1 receptor for pancreatic β-cell imaging. Bioorganic and Medicinal Chemistry. 2018. 26. 2. 463-469

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MISC (14)：

Mayumi Sasaki, Shimpei Fujimoto, Yuichi Nishi, Eri Mukai, Gen Yamano, Yuichi Sato, Hiroki Sato, Yumiko Tahara, Kasane Ogura, Kazuaki Nagashima, et al. Persistent Reduction of ROS Ameliorates Metabolism-Secretion Coupling in Cultured Diabetic GK Islets by Suppressing Warburg Effect. DIABETES. 2012. 61. A541-A541
Toyoda Kentaro, Kimura Hiroyuki, Mukai Eri, Ogawa Yuu, Fujimoto Hiroyuki, Ueda Masashi, Temma Takashi, Kawashima Hidekazu, Hirao Konomu, Matsuda Hirokazu, et al. Non-Invasive PET Imaging of Pancreatic Islets Targeting Glucagon-Like Peptide-1 Receptors. DIABETES. 2010. 59. A431
X. Liu, N. Harada, S. Yamane, A. Hamasaki, E. Mukai, K. Toyoda, C. Yamada, Y. Yamada, Y. Seino, N. Inagaki. Effects of long-term dipeptidyl peptidase-IV inhibiton on body composition and glucose tolerance under high-fat diet in mice. DIABETOLOGIA. 2009. 52. S309-S309
Yoshihito Fujita, Masaya Hosokawa, Shimpel Fujimoto, Eri Mukai, Abulizi Abudukadier, Akio Obara, Hideya Fujiwara, Yutaka Seino, Nobuya Inagaki. Metformin Suppresses Hepatic Gluconeogenesis and Lowers Blood Glucose Levels through Reactive Nitrogen Species. DIABETES. 2009. 58. A81-A81
河崎祐貴子, 原島伸一, 向英里, 佐々木真弓, 中村靖彦, 原田範雄, 山田千積, 豊田健太郎, 山田祐一郎, 清野裕, et al. Exendin-4はJNKとp38の脱リン酸化を介してRapamycin誘発性膵β細胞アポトーシスを抑制する. 糖尿病. 2009. 52. Suppl.1. S-223

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Books (17)：

Topics 最新の論文紹介エキセンジン-4は糖尿病Goto-Kakizaki(GK)ラット膵島でEpac依存性にSrc活性とROS産生を抑制する,Diabetes Strategy, 2-1
先端医学社 2012
「低血糖についての新しい知見」1.インクレチン関連薬とスルホニル尿素薬のによる低血糖,糖尿病,54-12
(社)日本糖尿病学会 2011
III-5. インクレチン関連薬とSU薬併用時における重症低血糖発症メカニズムとその対策,日本臨床,69-5(特集インクレチン関連薬-糖尿病治療のパラダイムシフト)
(株)日本臨床社 2011
Clinical Note DPP-4阻害薬とSU薬併用による低血糖,Diabetes Journal(糖尿病と代謝),39-1
(株)協和企画 2011
6 糖代謝異常と2型糖尿病の膵β細胞機能障害,2型糖尿病における膵β細胞最新研究の進歩寺内康夫編
診断と治療社 2008

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Lectures and oral presentations (55)：

PKCによる膵β細胞インスリン分泌増強に対するPKAの関与
(第62回日本糖尿病学会年次学術集会 2019)
白甘藷は膵β細胞からのインスリン分泌を促進し食後血糖値の上昇を抑制する
(第62回日本糖尿病学会年次学術集会 2019)
ゴーヤー抽出物は膵β細胞からのインスリン分泌を増強する
(第62回日本糖尿病学会年次学術集会 2019)
食後血糖値に対する短時間の低強度運動の抑制効果と分岐鎖アミノ酸の増強効果
(第62回日本糖尿病学会年次学術集会 2019)
White-skinned sweet potato stimulates insulin secretion from pancreatic β cells.
(9th Federation of the Asian and Oceanian Physiological Societies Congress 2019)

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Education (3)：

- 2001 Kyoto University Graduate School of Medicine, Internal Medicine Major
- 1997 Kyoto University Graduate School of Human and Environmental Studies Human and Environmental Studies Major
- 1995 Kyoto Prefectural University Department of Agriculture Department of Agricultural Chemistry

Professional career (2)：

Master of Human and Environmental Studies (Kyoto University)
Ph.D. in Medicine (Kyoto University)

Work history (17)：

2022/04 - 現在 Ritsumeikan University College of Llife Science
2016/04 - 2022/03 Ritsumeikan University College of Llife Science
2012/04/01 - 2016/03/31 Chiba University Graduate School of Medicine
2011/04/01 - 2012/03/31 Kyoto University Hospital
2010/04/23 - 2011/03/31 Kyoto University Graduate School of Medicine

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Awards (2)：

2011/11 - 日本糖尿病・肥満動物学会第25回日本糖尿病・肥満動物学会若手研究奨励賞受賞
2006/07 - 日本DDS学会第22回日本DDS学会学術集会優秀ポスター賞受賞

Association Membership(s) (5)：

Japan Society of Nutrition and Food Science , Physiological Society of Japan , Japan Society of Experimental Diabetes and Obesity , Japan Society of Metabolism and Clinical Nutrition , The Japan Diabetes Society

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