Rchr
J-GLOBAL ID:200901035418158812
Update date: Jan. 31, 2024
Nakayama Keiichi
ナカヤマ ケイイチ | Nakayama Keiichi
Affiliation and department:
Homepage URL (1):
http://www.bioreg.kyushu-u.ac.jp/saibou/index.html
Research field (3):
Immunology
, Cell biology
, Molecular biology
Research keywords (4):
細胞生物学
, 分子生物学
, Cell Biology
, Molecular Biology
Research theme for competitive and other funds (64):
- 2018 - 2023 幹細胞における細胞周期の制御と代謝系との連関に関する総合的研究
- 2017 - 2022 Trans-omic analysis of metabolic adaptation
- 2017 - 2018 がん細胞の代謝アダプテーション
- 2017 - 2018 代謝リモデリングによる適者生存メカニズムの研究
- 2015 - 2018 Epigenetic regulation of stem cell aging and organismal aging
- 2015 - 2018 Mechanism of PKD activation for monoamine release
- 2013 - 2018 幹細胞維持分子の機能解析と全身の幹細胞の可視化を目指した総合的研究
- 2016 - 2017 Elucidating the metabolic enzymes network in hypoxic cells using next-generation proteomics
- 2015 - 2017 新規モデルマウスを用いた自閉症マイクロエンドフェノタイプの解明
- 2015 - 2017 Elucidation of the mechanisms for Fbxw7 to suppress cancer metastasis in cancer niches
- 2015 - 2016 Deciphering the signal transduction pathway linking nutrition and inflammation
- 2013 - 2016 Elucidating the molecular mechanism of Warburg effect in cancer cells with iMRM
- 2013 - 2016 Method for determination of cellar pathway structure using multidimensional proteomics
- 2010 - 2016 Development of Novel Treatment Strategies Targeting Cancer Stem Cells
- 2014 - 2015 Elucidation of Warburg effect in cancer with the next-generation proteomics
- 2013 - 2015 Identification of an embryonic origin of adult neural stem cells
- 2012 - 2015 Elucidation of the mechanisms that control aging and cancer by chromatin remodeling
- 2010 - 2015 癌幹細胞の細胞周期制御機構の解明と治療法の開発
- 2013 - 2014 Functional analysis of a candidate gene for autism spectrum disorder
- 2010 - 2013 小胞輸送制御分子プロトルーディンの神経機能における役割の解明
- 2009 - 2011 The basic analysis of cell cycle association molecules by controlling the function aiming at application to liver regeneration treatment.
- 2007 - 2011 Mechanisms of cell cycle arrest and its interaction with cell differentiation during development
- 2005 - 2010 タンパク質分解異常による発がん機構の研究
- 2005 - 2010 神経突起形成のマスター分子Protrudinの発見と機能解析
- 2009 - 2010 生殖細胞特異的クロマチン修飾因子の機能解析
- 2009 - 2010 高感度定量プロテオミクスを用いたユビキチンリガーゼ基質探索
- 2008 - 2010 神経機能調節におけるRabファミリーの制御機構
- 2008 - 2010 神経分化と機能制御における膜輸送の役割
- 2007 - 2008 The basic analysis of cell cycle association molecules by controlling the function aiming at application to liver regeneration treatment
- 2007 - 2008 神経変性疾患における膜輸送システムの関与の解析
- 2006 - 2007 ProtrudinによるRabおよび膜輸送の制御機構の解析
- 2006 - 2007 異常タンパク質蓄積による神経変性疾患発症の分子機構の解明
- 2006 - 2007 神経管形成における多機能シャペロンFKBP38の機能解析
- 2006 - 2007 リン酸化ペプチドの網羅的解析のための新技術開発
- 2005 - 2006 新規Cullin/Rbx型E3ユビキチンリガーゼ群の機能解析
- 2003 - 2005 発生工学プロテオミクスを用いたPKC-δシグナル伝達系の解明
- 2005 - 2005 神経突起伸長におけるFKBP38の機能解析
- 2005 - 2005 異常タンパク質蓄積による神経変性疾患発症の分子機構の解明
- 2005 - 2005 中枢神経系領域形成におけるFKBP38の機能解析
- 2004 - 2005 細胞内タンパク質の特異的分解制御による癌に対する遺伝子治療法の確立
- 2004 - 2005 Analysis of degradation of cell cycle regulators Kip family
- 2004 - 2005 Comprehensive analysis of molecules related for antigen receptor signaling
- 2001 - 2005 Regulation of by protein degradation and transport.
- 2004 - 2004 異常タンパク質蓄積による神経変性疾患発症の分子機構の解明
- 2003 - 2004 Study of molecular mechanisms of CD4 silencing and role s of Runx proteins during lymphocyte development
- 2003 - 2004 プロテアソームへのユビキチン化基質のターゲッテング機構の解析
- 2000 - 2004 Investigation into the molecular mechanisms underlying proteolysis of CDK inhibitor p27
- 2002 - 2002 プロテアソームへのユビキチン化基質のターゲッテング機構の解析
- 2001 - 2002 Establishment of therapeutic method for neurodegenerative diseases by specific protein degradation system for abnormal proteinsEstablishment of therapeutic method for neurodegenerative diseases by specific protein degradation system for abnormal proteins
- 2001 - 2002 New cancer therapy by degradation of specific proteins
- 2001 - 2002 New clearance system of abnormal protein in Polyglutammine disease
- 2001 - 2002 Axamノックアウトマウスの作製とその解析
- 2000 - 2001 Functional analysis of ubiquitin ligase by knock-out mise
- 1999 - 2001 MOLECULAR MECHANISMS OF CARDIOVASCULAR REMODELING INDUCED BY CHRONIC INHIBITION OF NITRIC OXIDE SYNTHESIS : ROLE OF NF-_B AND MCP-1
- 1999 - 2000 Identification of the factors mediating ubiquitination of inclusion body in neurodegenerative diseases
- 1999 - 2000 細胞周期調節分子の分解制御に関する研究-マウスSCF複合体の遺伝子クローニングと解析-
- 1998 - 2000 MOLECULAR MECHANISMS OF CARDIOVASCULAR REMODELING INDUCED BY CHRONIC INHIBITION OF NITRIC OXIDE SYNTHESIS : ROLE OF NF-κB AND MCP-1
- 1998 - 1999 Regulation of degradation of p27Kip1, one of CDK inhibitory protein, for cancer therapy
- 1998 - 1999 Identification and functional analysis of S phase promoting complex in mammalian cell growth
- 1998 - 1998 細胞周期調節分子の分解制御に関する研究 - Yeast three-hybrid法の確立と応用 -
- 1998 - 1998 多角的戦略に基づく組換えアデノウィルスによる固形癌の遺伝子治療法の開発
- 1998 - 1998 サイクリン依存性キナーゼ阻害分子の分解機構の解明
- 1997 - 1998 Analysis of sinnalling pathway of apoptosis degradation using PKCδ gene-targeting mice
- Investigation into the molecular mechanism of Cell-growth and Cell-death control
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Papers (475):
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Yuhei Chadani, Takashi Kanamori, Tatsuya Niwa, Kazuya Ichihara, Keiichi I. Nakayama, Akinobu Matsumoto, Hideki Taguchi. Mechanistic dissection of premature translation termination induced by acidic residues-enriched nascent peptide. Cell Reports. 2023. 42. 12. 113569-113569
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Yusuke Temma, Kisho Obi-Nagata, Yoshio Hoshiba, Ryuhei Miyake, Yuta Katayama, Hideo Hagihara, Norimitsu Suzuki, Tsuyoshi Miyakawa, Keiichi I. Nakayama, Akiko Hayashi-Takagi. Effect of brain acidification on depression-related behaviors in diabetes mellitus. Frontiers in Psychiatry. 2023. 14
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Shigeaki Sugiyama, Kanae Yumimoto, Shun Fujinuma, Keiichi I Nakayama. Identification of effective CCR2 inhibitors for cancer therapy using humanized mice. Journal of biochemistry. 2023
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Hideki Maehara, Toshiya Kokaji, Atsushi Hatano, Yutaka Suzuki, Masaki Matsumoto, Keiichi I. Nakayama, Riku Egami, Takaho Tsuchiya, Haruka Ozaki, Keigo Morita, et al. DNA hypomethylation characterizes genes encoding tissue-dominant functional proteins in liver and skeletal muscle. Scientific Reports. 2023. 13. 1
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Shintaro Funasaki, Atsushi Hatano, Hirokazu Nakatsumi, Daisuke Koga, Osamu Sugahara, Kanae Yumimoto, Masaya Baba, Masaki Matsumoto, Keiichi I. Nakayama. A stepwise and digital pattern of RSK phosphorylation determines the outcome of thymic selection. iScience. 2023. 26. 9. 107552-107552
more...
MISC (31):
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松本有樹修, 市原知哉, 西田紘士, 今見考志, 石濱泰, 中山敬一. Combinatorial analysis of translatome and proteome unveils the importance of hidden ORFs. 日本分子生物学会年会プログラム・要旨集(Web). 2021. 44th
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市原知哉, 松本有樹修, 西田紘士, 今見孝志, 石濱泰, 中山敬一. Molecular mechanism and biological significance of non-AUG translation initiation revealed by precise identification of translation initiation sites. 日本分子生物学会年会プログラム・要旨集(Web). 2021. 44th
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Surveys for mTOR Targets by Proteomic Analysis. 2012. 31. 12. 1360-1367
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Proteomics for the study on cell cycle regulation. Cell technology. 2009. 28. 1. 59-64
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Hirobumi Tada, Hirotaka James Okano, Hiroshi Takagi, Ikuko Yao, Toru Saiga, Masaki Matsumoto, Koiichi I. Nakayama, Haruo Kashima, Takuya Takahashi, Mitsutoshi Setou, et al. Kspot, a novel ubiquitin ligase, regulates synaptic activity. NEUROSCIENCE RESEARCH. 2008. 61. S218-S218
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Education (4):
- 1986 - 1990 Juntendo University
- - 1990 Juntendo University Graduate School, Division of Medicine
- 1980 - 1986 Tokyo Medical and Dental University Faculty of Medicine School of Medicine
- - 1986 Tokyo Medical and Dental University Faculty of Medicine
Professional career (1):
Work history (6):
Committee career (2):
- 2005 - 2006 日本分子生物学会 評議員
- 2005 - 日本癌学会 評議員
Awards (7):
Association Membership(s) (5):
日本プロテオーム学会
, 日本癌学会
, 日本分子生物学会
, 日本癌学会
, 日本分子生物学会
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