Rchr
J-GLOBAL ID：200901035420361676
Update date: Mar. 04, 2024
Kubo Kin-ya
Kubo Kin-ya
Affiliation and department：
Job title：
Professor
Research field (3)：
Community dentistry
, Developmental dentistry
, Neuroscience - general
Research keywords (7)：
mastication
, cognitive function
, stress
, osteoporosis
, obesity
, diabetes mellitus
, cancer
Research theme for competitive and other funds (26)：
- 2023 - 2027 Elucidation of mechanism of metabolic suppression in offspring by perinatal stress during mastication
- 2022 - 2025 Can salivary secretion be an important modulator of reducing postprandial blood glucose increment?
- 2020 - 2023 転移がん発症に及ぼす咀嚼刺激の影響
- 2018 - 2022 Elucidation of the neural circuit for the stress suppression mechanism in of chewing and its application to biological stress suppression
- 2017 - 2020 Establishment of methodology for controlling postprandial blood sugar to regulate free-water in intestinal contents for clinical application
- 2017 - 2020 Effects of chewing on psychological stress-related breast cancer
- 2016 - 2019 Effect of Oral environment on hippocampal network in the erderly
- 2015 - 2018 Effect of oral environment on declining cognitive function of the elderly
- 2014 - 2018 Elucidation of intracerebral mechanism of stress reduction effect in amygdala by Chewing
- 2014 - 2017 Maternal chewing during prenatal stress ameliorates stress-induced lower bone mass in adult offspring
- 2015 - 2017 Effects of chewing during prenatal stress on diabetes onset in mouse offspring
- 2012 - 2016 Maternal occlusal disharmony produces the learning deficits by the altered hippocampal neurogenesis, enriched enviroment of pups ameliorates the learning deficits
- 2011 - 2013 Chewing ameliorates stress-induced osteoporosis in mouse
- 2010 - 2012 Maternal chewing prevents stress-induced learning impairment in pups
- 2009 - 2011 Oral care-induced activation and reproduction of the functional brain cognitive circuit in the elderly
- 2008 - 2011 Effects of chronic stress of early tooth extraction on hippocampus in senescence-accelerated mice
- 2007 - 2009 Protective effect on stress-related memory deficits by chewing
- 2007 - 2009 The induction mechanism of new bone formation by sintered carbonate apatite grafted into bone
- 2006 - 2007 高齢社会において老年歯科医学が担う社会的重要性を脳科学的に実証する
- 2006 - 2007 The effect of bite-raised condition on dendritic spine number in hippocampus
- 2005 - Chewing prevents the stress-induced impairment of hippocampal function
- 2003 - 2004 Chewing effects on intelligent activities in the elderly
- 2003 - 2003 噛むことによる小児のストレス発散の神経科学的解明-磁気共鳴機能画像法による研究-
- 2002 - 2003 Chewing effects on intelligent activities
- 2002 - 2002 咀嚼運動によるストレス緩和:fMRI解析
- 2002 - チューイングによるストレス緩和機構の神経科学的解明
Show all
Papers (98)：
-
Suzuko Ochi, Kumiko Yamada, Takashi Saito, Takaomi C. Saido, Mitsuo Iinuma, Kagaku Azuma, Kin-Ya Kubo. Effects of early tooth loss on chronic stress and progression of neuropathogenesis of Alzheimer’s disease in adult Alzheimer’s model AppNL-G-F mice. Frontiers in Aging Neuroscience. 2024. 16
-
Chie Hisada, Kyoko Kajimoto, Hiroko Tsugane, Iinuma Mitsuo, Kagaku Azuma, Kin-Ya Kubo. Maternal chewing alleviates prenatal stress-related neuroinflammation mediated by microglia in the hippocampus of the mouse offspring. Journal of prosthodontic research. 2023. 67. 4. 588-594
-
Jia-He Zhang, Ke-Yong Wang, Kin-Ya Kubo, Kagaku Azuma. Chewing Behavior Attenuates Lung-Metastasis-Promoting Effects of Chronic Stress in Breast-Cancer Lung-Metastasis Model Mice. Cancers. 2022. 14. 23
-
Jia-He Zhang, Takashi Tasaki, Manabu Tsukamoto, Ke-Yong Wang, Kin-Ya Kubo, Kagaku Azuma. Deletion of Wnt10a Is Implicated in Hippocampal Neurodegeneration in Mice. Biomedicines. 2022. 10. 7
-
Kyoko Kajimoto, Chie Hisada, Suzuko Ochi, Eri Yoshikawa, Ayumi Suzuki, Hiroko Tsugane, Jiahe Zhang, Mitsuo Iinuma, Kin-Ya Kubo, Kagaku Azuma. Maternal chewing improves prenatal stress-induced cognitive deficit and anxiety-like behavior associated with alterations of the apoptotic response and serotonin pathway in mouse offspring. Archives of oral biology. 2021. 130. 105245-105245
ｍore...
MISC (157)：
-
井上 国見, 至田 康志, 苅谷 金弥, 倉嶋 秀樹, 長谷川 隆, 畑山 勝浩, 駒形 俊和, 佐野 毅, 平井 啓一, 應田 豊雄, et al. 【先進的な信頼確保~使用者リスクの低減に向けて~】(第7章)連続生産の最新動向 連続生産の実装加速に向けて ICH Q13の施行. PHARM TECH JAPAN. 2023. 39. 5. 960-983
-
梶本 京子, 越智 鈴子, 津金 裕子, 飯沼 光生, 齊藤 一誠, 東 華岳, 久保 金弥. 妊娠期ストレス中の母獣の顎運動が胎盤バリア機能に及ぼす影響. 小児歯科学雑誌. 2023. 61. 大会抄録号. 248-248
-
梶本 京子, 越智 鈴子, 津金 裕子, 飯沼 光生, 齊藤 一誠, 東 華岳, 久保 金弥. 妊娠期ストレス中の母獣の顎運動が胎盤バリア機能に及ぼす影響. 小児歯科学雑誌. 2023. 61. 大会抄録号. 248-248
-
梶本 京子, 杉本 勘太, 久田 智詠, 越智 鈴子, 津金 裕子, 飯沼 光生, 齊藤 一誠, 東 華岳, 久保 金弥. 母マウスの咀嚼運動が仔の海馬のミクログリアに及ぼす影響. 小児歯科学雑誌. 2022. 60. 大会抄録号. 229-229
-
津金 裕子, 尾辻 渉, 片野 雅久, 越智 鈴子, 梶本 京子, 鈴木 あゆみ, 齊藤 一誠, 飯沼 光生, 東 華岳, 久保 金弥. 歯の早期喪失が海馬のBDNF発現と情動障害に及ぼす影響. 小児歯科学雑誌. 2022. 60. 大会抄録号. 230-230
ｍore...
Books (4)：
-
噛むチカラでストレスに勝つ
健康と良い友だち社 2011
-
Involvement of dysfunctional mastication in cognitive system deficits in the mouse: in Novel Trends in Brain science (M. Onozuka, C.-T. Yen, eds.)
Springer 2008
-
Interactions between chewing and brain activity in human: in Novel Trends in Brain Science (M. Onozuka, C.-T. Yen eds.)
Springer 2008
-
リープゴット 歯科学のための解剖学
西村書店 2006
Lectures and oral presentations (20)：
-
母マウスの咀嚼運動が仔の海馬のミクログリアに及ぼす影響
(小児歯科学雑誌 2022)
-
歯の早期喪失が海馬のBDNF発現と情動障害に及ぼす影響
(小児歯科学雑誌 2022)
-
歯の早期喪失がアルツハイマー病の発症に及ぼす影響 第三世代アルツハイマー病モデルマウスを用いて
(小児歯科学雑誌 2022)
-
妊娠母体の咀嚼運動が仔のLPS投与におけるミクログリアの活性化に及ぼす影響
(小児歯科学雑誌 2021)
-
妊娠母体の咀嚼が新生仔の海馬の神経細胞数とアストロサイトに及ぼす影響
(小児歯科学雑誌 2019)
ｍore...
Professional career (1)：
- Doctor of Philosophy (Doctor of Medicine) (Gifu University)
Work history (2)：
- 2017/04 - 2019/03 Nagoya Women's University Faculty of Human Life and Environmental Science
- 2009/10 - 2018/03 Seijoh University Seijoh University
Committee career (2)：
- 2011 - 現在 日本解剖学会 評議員
- 2011 - 現在 老化促進モデルマウス(SAM)学会 評議員
Association Membership(s) (4)：
THE JAPANESE SOCIETY OF PEDIATRIC DENTISTRY
, 老化促進マウス(SAM)学会
, 日本神経科学学会
, 日本解剖学会
