Rchr
J-GLOBAL ID：200901036292404916   Update date: Jan. 30, 2024

Siomi Haruhiko

シオミ ハルヒコ | Siomi Haruhiko
Affiliation and department：
Keio University School of Medicine

About Keio University School of Medicine


Job title： Professor
Homepage URL  (1)： http://siomilab.med.keio.ac.jp/
Research field  (1)： Genetics
Research keywords  (2)： RNA-binding protein, small RNA, transposable elements, RNA silencing, RNAi ,  RNA-binding protein
Research theme for competitive and other funds  (10)：
  • 2019 - 2024 Understanding of totipotency through characterization of interactions between transposable elements and early embryos
  • 2019 - 2024 Program for Totipotency
  • 2014 - 2018 Elucidation of molecular mechanisms of RNA silencing
  • 2013 - 2018 霊長類を含む哺乳動物の生殖エピゲノム形成機構
  • 2008 - 2013 転移因子とArgonauteの軍拡競争からゲノムの進化を探る
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Papers (131)：
  • Akihiko Sakashita, Tomohiro Kitano, Hirotsugu Ishizu, Youjia Guo, Harumi Masuda, Masaru Ariura, Kensaku Murano, Haruhiko Siomi. Transcription of MERVL retrotransposons is required for preimplantation embryo development. Nature Genetics. 2023
  • Setsuko Mise-Omata, Mari Ikeda, Masaru Takeshita, Yoshifumi Uwamino, Masatoshi Wakui, Tomoko Arai, Ayumi Yoshifuji, Kensaku Murano, Haruhiko Siomi, Kensuke Nakagawara, et al. Memory B Cells and Memory T Cells Induced by SARS-CoV-2 Booster Vaccination or Infection Show Different Dynamics and Responsiveness to the Omicron Variant. Journal of immunology (Baltimore, Md. : 1950). 2022. 209. 11. 2104-2113
  • Kodai Abe, Yasuaki Kabe, Susumu Uchiyama, Yuka W. Iwasaki, Hirotsugu Ishizu, Yoshifumi Uwamino, Toshiki Takenouchi, Shunsuke Uno, Makoto Ishii, Takahiro Maruno, et al. Pro108Ser mutation of SARS-CoV-2 3CLpro reduces the enzyme activity and ameliorates the clinical severity of COVID-19. Scientific Reports. 2022. 12. 1. 1299-1299
  • Ten D Li, Kensaku Murano, Tomohiro Kitano, Youjia Guo, Lumi Negishi, Haruhiko Siomi. TDP-43 safeguards the embryo genome from L1 retrotransposition. Science advances. 2022. 8. 47. eabq3806
  • Chikara Takeuchi, Moe Yokoshi, Shu Kondo, Aoi Shibuya, Kuniaki Saito, Takashi Fukaya, Haruhiko Siomi, Yuka W Iwasaki. Mod(mdg4) variants repress telomeric retrotransposon HeT-A by blocking subtelomeric enhancers. Nucleic acids research. 2022. 50. 20. 11580-11599
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MISC (17)：
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Education (3)：
  • - 1988 Kyoto University Graduate School of Medicine
  • - 1984 Gifu University
  • - 1982 Gifu University Agricultural Chemistry
Professional career (1)：
  • Doctor of Medical Science
Work history (6)：
  • 2008/02 - 現在 Keio University School of Medicine Professor
  • 2021/10 - 2023/09 Keio University School of Medicine Vice Dean (in charge of research)
  • 1999 - 2008 The University of Tokushima
  • 1997 - 1999 米国ペンシルバニア大学Research Assistant Professor
  • 1990 - 1997 米国ペンシルバニア大学研究員
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Committee career (7)：
  • 2018/04 - 現在 JST 戦略的創造研究推進事業「ゲノム合成」研究領域 CREST/さきがけ 領域総括
  • 2018/04 - 2020/03 日本学術振興会 学術システム研究センター 主任研究員
  • 2016/04 - 2018/03 日本学術振興会 学術システム研究センター 研究員
  • 2016 - 2018 The RNA Society Director
  • 2012/04 - 2016/03 文部科学省 科学官
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Awards (4)：
  • 1989: 東燃賞
  • 2000: CAN Foundation Research Award
  • 1999: FRAXA Research Foundation Award
  • 1998: MRDDRC Young Investigator Award
Association Membership(s) (5)：
The RNA Society ,  日本分子生物学会 ,  日本RNA学会 ,  The RNA Society of Japan ,  The Moleular Biology Society of Japan
※ Researcher’s information displayed in J-GLOBAL is based on the information registered in researchmap. For details, see here.

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