Suzuki Toyofumi

スズキトヨフミ | Suzuki Toyofumi

Affiliation and department：
Job title： Professor

Research field (4)： Clinical pharmacy , Clinical pharmacy , Clinical pharmacy , Clinical pharmacy

Research keywords (12)： Drug Delivery to the Brain , Blood-Brain Barrier Transport , Nose-to-Brain , Intranasal formulations , 点鼻薬/点鼻剤 , 経鼻吸収 , transdermal therapeutic system , Cerebral Ischemia , cerebral ischemic reperfusion injury , 半固形製剤 , Syrup for Infants , Orally disintegrating tablet

Research theme for competitive and other funds (21)：

2019 - 2021 鼻から脳への薬物移行経路を介した経鼻投与製剤の基盤技術の開発と中枢疾患治療戦略
2017 - 2020 脳神経系希少疾患治療を目指した経鼻投与による脳内バイオ医薬デリバリー戦略の構築
2018 - 2019 薬物封入ナノキャリアが虚血性脳梗塞急性期における脳神経保護効果に及ぼす影響
2018 - 2018 脳松果体から分泌される中分子ペプチドホルモン・メラトニンの鼻から脳への薬物送達とその移行経路の解明
2017 - 2018 虚血性脳梗塞に対する薬物の経鼻投与経路の有用性

2013 - 2015 皮膚老化の進行過程を抑制するための抗酸化作用を有する物質の皮内送達法の探索

2013 - 2014 グルタミン酸受容体及び酸感受性イオンチャネルを分子標的としたビグアニド誘導体の新規脳機能保護薬としての有用性

2011 - 2012 NMDAR及びASICを分子標的とした脳梗塞改善薬の開発研究

2010 - 2012 老化を基礎とする疾患の発症・進展の予防を目的とした薬物の脳内移行特性の解明と応用

2009 - 2010 血液脳関門におけるアミノ酸輸送に及ぼす脳虚血/再灌流障害の影響

2008 - 2010 エプタゾシン等の経皮吸収剤化に関する研究

2008 - 2009 一過性脳虚血障害による血液脳関門破綻の蛍光イメージング

2007 - 2008 麻薬拮抗薬の血液脳関門取り込み輸送に関わる有機カチオントランスポーターの役割

2006 - 2007 薬物輸送担体を利用した非麻薬性鎮痛薬の鎮痛作用増強に関する研究

2005 - 2007 アポトーシス誘導型新規化学療法の検索:抗がん剤に抵抗性を獲得したヒトがん細胞に対して

2005 - 2006 麻薬拮抗性鎮痛薬の血液脳関門排出における輸送担体の関与

2001 - 2002 Development of non-oral type sustained release formulation for pain control

2000 - 2002 Development of the antibacterial biomaterial for the clinical use

2000 - 2001 Distribution control and transport mechanism of the basic drugs across the blood-brain barrier

2000 - 2001 Development of non-oral pharmaceutical formulation for the management of cancer-related and postoperative pain

1998 - 1999 Kinetic analysis of the transport mechanism of pentazocine across the blood-brain barrier

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Papers (128)：

Ayumi Kashiwada, Narumi Taoka, Yukiha Chijimi, Keiko Noguchi, Karin Shigematsu, Motofumi Miura, Toyofumi Suzuki. Weakly acidic pH-responsive liposomal content release induced by histidine-modified agents. Organic & Biomolecular Chemistry. 2024. 22. 2844-2850
Naoto Suzuki, Hiroaki Tanigawa, Taiki Nagatomo, Hiroko Miyagishi, Takanori Kanazawa, Toyofumi Suzuki, Yasuhiro Kosuge. Utility of a Novel Micro-Spraying Device for Intranasal Administration of Drug Solutions to Mice. Pharmaceutics. 2023. 15. 11. 2553
Komugi Tsuruta, Takato Shidara, Hiroko Miyagishi, Hiroshi Nango, Yoshihiko Nakatani, Naoto Suzuki, Taku Amano, Toyofumi Suzuki, Yasuhiro Kosuge. Anti-Inflammatory Effects of Miyako Bidens pilosa in a Mouse Model of Amyotrophic Lateral Sclerosis and Lipopolysaccharide-Stimulated BV-2 Microglia. International Journal of Molecular Sciences. 2023. 24. 18
Muramori So, Yasuhiro Tsuji, Toyofumi Suzuki. Efficacy of zinc acetate hydrate for hypozincemia in the elderly is influenced by the initial accumulated exposure dose after taking zinc acetate hydrate. Pharmazie. 2023. 78. 9-10. 201-206
Takumi Kurano, Takanori Kanazawa, Shingo Iioka, Hiromu Kondo, Yasuhiro Kosuge, Toyofumi Suzuki. Intranasal administration of N-acetyl-L-cysteine combined with cell-penetrating peptide-modified polymer nanomicelles as a potential therapeutic approach in amyotrophic lateral sclerosis. Pharmaceutics. 2022. 14. 12. 2590

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MISC (141)：

飯岡真吾, 金沢貴憲, 藏野匠, 小菅康弘, 鈴木豊史, 近藤啓. Therapeutic effects by siRNA-loaded Nose-to-Brain micelles in ALS model mice. 日本核酸医薬学会年会講演要旨集(CD-ROM). 2022. 7th
藏野匠, 渋市梨子, 鶴田こむぎ, 村山弘樹, 山崎海斗, 小菅康弘, 小菅康弘, 鈴木豊史, 鈴木豊史, 金沢貴憲, et al. Improvement of distribution in the spinal cord and life-prolongation effect in ALS model mice by intranasal administration of NAC combined with cell-penetrating peptide-modified polymer micelles. 日本薬剤学会年会講演要旨集(CD-ROM). 2021. 36th
鈴木豊史, 鈴木直人, 橋崎要, 長友太希, 柳侑里, 金沢貴憲. Quantitative evaluation of the nasal retention of temperature-sensitive in situ gel using 3D human nasal cavity model. 日本薬学会年会要旨集(Web). 2020. 140th
鶴田こむぎ, 藏野匠, 浅山涼, 吉野正洋, 山口真侑, 鈴木直人, 和田平, 小菅康弘, 榛葉繁紀, 鈴木豊史, et al. 細胞透過性ペプチド修飾高分子ミセル併用経鼻投与によるsiRNAの筋萎縮性側索硬化症マウスにおける脊髄内分布と標的mRNA発現抑制効果. 日本薬学会関東支部大会講演要旨集. 2020. 64th
山口真侑, 福田光良, 出森大登, 鈴木茉璃乃, 飯岡真吾, 飯岡真吾, 鈴木直人, 金沢貴憲, 鈴木豊史. 水溶性中分子のNose-to-Brain動態に及ぼす鼻腔内投与条件の影響. 日本薬学会関東支部大会講演要旨集. 2020. 64th

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Patents (13)：

Pharmaceutical composition for external use (Canada)
Pharmaceutical composition for external use (South Korea)
Matrix-type patch preparation and method for producing same (Taiwan)
Externally-applied medicinal composition (China)
Pharmaceutical composition for external use (USA)

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Books (10)：

新規モダリティ医薬品のための新しいDDS技術と製剤化
Technical Information Institute Co., Ltd. 2023 ISBN:9784861049361
「薬物療法の質を大きく変える剤形・投与経路Q&A」月刊薬事2022年4月臨時増刊号(Vol. 64 No. 6)
(株)じほう 2022
Clinical Pharmaceutics <5rd Edition>
NANKODO 2022 ISBN:9784524403936
できる薬剤師とよばれるために-上手に使いたい薬学ナレッジ101
(株)じほう 2021 ISBN:9784840754019
医薬品におけるDDS技術開発と製剤への応用
Johokiko Co., Ltd. 2021 ISBN:9784865022278

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Lectures and oral presentations (635)：

Effect of preparation conditions or kind of mesoporous silica on powderization of ionic liquids by encapsulation in porous silica[27P2-am1-083S]
(The 143th Annual Meeting of the Pharmaceutical Society of Japan (Sapporo). March 25th-28th, 2023 2023)
Comparison of physical stability of cocrystals consisting of curcumin under high temperature and humidified conditions[27P2-am1-108]
(The 143th Annual Meeting of the Pharmaceutical Society of Japan (Sapporo). March 25th-28th, 2023 2023)
Correlation between serum zinc concentration and efficacy of zinc acetate hydrate[27P2-pm2-091S]
(The 143th Annual Meeting of the Pharmaceutical Society of Japan (Sapporo). March 25th-28th, 2023 2023)
Neuroprotective effects in the brain by intranasal edaravone of improved solubility with PEG[26P2-pm2-079S]
(The 143th Annual Meeting of the Pharmaceutical Society of Japan (Sapporo). March 25th-28th, 2023 2023)
Nose-to-brain/spinal cord delivery kinetics of liposomes with different surface properties
(The 37th Annual Meeting of The Japanese Society for the Study of Xenobiotics in Yokohama (Yokohama) 2022)

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Professional career (1)：

博士(薬学) (日本大学)

Work history (6)：

2016/04 - 現在 School of Pharmacy, Nihon University Laboratory of Pharmaceustics Professor
2011/04 - 2016/03 School of Pharmacy, Nihon University Laboratory of Pharmaceutics Associate Professor
2004/04 - 2011/03 School of Pharmacy, Nihon University Laboratory of Pharmaceutics Lecturer
2003/09 - 2004/03 School of Pharmacy, Nihon University Laboratory of Pharmaceutics Assistant Professor
2002/08 - 2003/09 University of California at Los Angeles (UCLA), School of Medicine Department of Medicine/Endocrinology (Prof. Pardridge) Postgraduate Scientist (Visiting Researcher)

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Committee career (15)：

2019/02 - 現在 The Pharmaceutical Society of Japan 代議員
2018/04 - 現在 The Academy of Pharmaceutical Science and Technology, Japan (APSTJ) 代議員
2023/10 - 2024/03 The Pharmaceutical Society of Japan The Pharmaceutical Society of Japan
2023/04 - 2024/03 Ministry of Health, Labour and Welfare The 109th Pharmacist National Examination, Pharmacy Examination Board
2021/10 - 2024/03 The Pharmaceutical Society of Japan The Pharmaceutical Society of Japan

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Awards (6)：

2021/09 - Japan Oil Chemists' Society The 20th Japan Oil Chemists' Society, Oleo Science Transport Mechanism in the Nose-to-Brain Drug Delivery and Role of Nanosystems
2017/10 - The 50th
2010/10 - 2010
2006/07 - The APSTJ Global Education Seminar The APSTJ Global Education Seminar Presentation Award 2006 Imaging endogenous gene expression in brain cancer in vivo with 111In-peptide nucleic acid antisense radiopharmaceuticals and brain drug-targeting technology
2005/06 - The Journal of Nuclear Medicine Editor's Selection Award 2004 (Outstanding Basic Science Investigation) from The Journal of Nuclear Medicine

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Association Membership(s) (5)：

Academy of Pharmaceutical Science and Tschnology of Japan (APSTJ) , The Japanese Society for the Study of Xenobiotics (JSSX) , The Pharmacutical Society of Japan#9305569 , 日本DDS学会 , The Japanese Society of Clinical Pharmacology and Therapeutics

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