Rchr
J-GLOBAL ID:200901036930390723   Update date: Mar. 01, 2024

Ito Kosei

イトウ コウセイ | Ito Kosei
Affiliation and department:
Job title: Associate Professor
Homepage URL  (1): http://www.de.nagasaki-u.ac.jp/dokuji/mbb/index.html
Research field  (4): Oral medicine (pathology) ,  Oral medicine ,  Tumor biology ,  Medical biochemistry
Research keywords  (6): RUNX ,  Osteosarcoma ,  分子腫瘍学 ,  RUNX3 ,  Cancer Research ,  RUNX3
Research theme for competitive and other funds  (14):
  • 2022 - 2025 組織マクロファージの動的恒常性維持機能を標的軸としたデザイナー細胞医薬の開発
  • 2021 - 2024 Integrated understanding of molecular mechanisms of osteosarcoma development focusing on Myc super-enhancer
  • 2019 - 2021 The essential transcriptional factor and its genomic element for the development of p53-deficient tumors
  • 2018 - 2020 RUNX転写因子の作用機序をターゲットにした革新的骨肉腫治療戦略の創出
  • 2015 - 2018 Investigation into etiology and pathology of eating disorder caused by neurotransmitter disorders and its treatment strategy
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Papers (99):
  • Qing Jiang, Xin Qin, Takeshi Moriishi, Ryo Fukuyama, Shinichi Katsumata, Hiroshi Matsuzaki, Hisato Komori, Yuki Matsuo, Chiharu Sakane, Kosei Ito, et al. Runx2 Regulates Galnt3 and Fgf23 Expressions and Galnt3 Decelerates Osteoid Mineralization by Stabilizing Fgf23. International journal of molecular sciences. 2024. 25. 4
  • Keisuke Omori, Shohei Otani, Yuki Date, Tomoya Ueno, Tomoko Ito, Masahiro Umeda, Kosei Ito. C/ebpα represses the oncogenic Runx3-Myc axis in p53-deficient osteosarcoma development. Oncogene. 2023
  • Kosei Ito, Shohei Otani, Yuki Date. p53 Deficiency-Dependent Oncogenicity of Runx3. Cells. 2023. 12. 8. 1122-1122
  • Otani S, Ohnuma M, Kosei Ito, Matsushita Y. Cellular dynamics of distinct skeletal cells and the development of osteosarcoma. Frontiers in Endocrinology. 2023. 14
  • Qing Jiang, Xin Qin, Kenichi Nagano, Hisato Komori, Yuki Matsuo, Ichiro Taniuchi, Kosei Ito, Toshihisa Komori. Different Requirements of CBFB and RUNX2 in Skeletal Development Among Calvaria, Limbs, Vertebrae and Ribs. International Journal of Molecular Sciences. 2022. 23. 21. 13299-13299
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MISC (28):
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Patents (1):
  • がん遺伝子の転写調節領域
Books (1):
  • Advances in Experimental Medicine and Biology 962; RUNX Proteins in Development and Cancer
    Springer 2017
Lectures and oral presentations  (12):
  • TGFβ signaling facilitates Myc upregulation by Runx in p53-deficient osteosarcoma development
    (2022)
  • p53 deficiency causes Myc dysregulation through a novel TGFβ-facilitated promoter switchingmechanism to instigate osteosarcoma development
    (AACR Annual Meeting 2022 2022)
  • Oncogenic Runx1-Myc axis in p53-deficient thymic lymphoma
    (EACR 2021 Virtual Congress (European Association for Cancer Research) 2021)
  • RUNX3 upregulates c-MYC via mR1-an essential genomic element for p53- deficient osteosarcoma-genesis
    (AACR Annual Meeting 2020 2020)
  • Oncogenic Runx3 in osteosarcoma development
    (RUNX-2019 conference 2019)
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Education (3):
  • 1993 - 1997 Kyoto University Graduate School of Medicine
  • 1991 - 1993 Kyoto University Graduate School of Agriculture
  • - 1991 Kyoto University Faculty of Agriculture
Professional career (3):
  • Doctor (Medical Science) (Kyoto University)
  • Master (Agriculture Science) (Kyoto University)
  • Bachelor (Agriculture Science) (Kyoto University)
Work history (6):
  • 2013/01 - 現在 Nagasaki University Graduate School of Biomedical Sciences
  • 2008/02 - 2010/03 Nagasaki University Graduate School of Biomedical Sciences
  • 2003/01 - 2008/02 National University of Singapore Senior Research Scientist
  • 2002/04 - 2008/02 シンガポール国立分子細胞生物学研究所 Research Assistant Professor
  • 2000/04 - 2002/03 Kyoto University Institute for Virus Research
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Committee career (1):
  • 2012 - 現在 科学誌 GENE 編集委員
Association Membership(s) (4):
日本癌学会 ,  日本分子生物学会 ,  Japanese Cancer Association ,  The Molecular Biology Society of Japan
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