Hisanaga Shin'ichi

ヒサナガシンイチ | Hisanaga Shin'ichi

Affiliation and department：
Job title： Professor
Homepage URL (1)： http://www.biol.se.tmu.ac.jp/labo.asp?ID=neumol

Research field (2)： Cell biology , Neuroscience - general

Research keywords (10)：包括脳ネットワーク , Neurodegenative Disease , Phosphorylation , Protein kinase , CIN85 , Tau , LMTK1 , Cdk5 , 神経生化学 , Neurobiochemistry

Research theme for competitive and other funds (6)：

1995 - CdK5 and Alzheimer disease
1992 - Regulation mechanism of CDK5 activation
1987 - Role of phosphorylation of neurofilament
神経細胞特異的中間径フィラメントneurofilamentのリン酸化と機能
Cdk5と神経変性疾患

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Papers (103)：

Tomoki Chiku, Motoki Hayashishita, Taro Saito, Mikiko Oka, Kanako Shinno, Yosuke Ohtake, Sawako Shimizu, Akiko Asada, Shin-Ichi Hisanaga, Koichi M Iijima, et al. S6K/p70S6K1 protects against tau-mediated neurodegeneration by decreasing the level of tau phosphorylated at Ser262 in a Drosophila model of tauopathy. Neurobiology of aging. 2018. 71. 255-264
Tarutani, A, Murayama, S, Hisanaga, S, Hasegawa, M. Potent prion-like behaviors of pathogenic a-synuclein and evaluation of inactivation methods. Neuropathol Commun. 2018. 6. 29
Dilina Tuerde, Taeko Kimura, Tomohiro Miyasaka, Kotaro Furusawa, Aki Shimozawa, Masato Hasegawa, Kanae Ando, Shin-Ichi Hisanaga. Isoform-independent and-dependent phosphorylation of microtubule-associated protein tau in mouse brain during postnatal development. Journal of Biological Chemistry. 2018. 293. 5. 1781-1793
Kimura, T, Sharma, G, Ishiguro, K, Hisanaga, S. Phospho-tau bar code: analysis of phosphoisotypes of tau and its application to tauopathy. Fron. Mol. Neurosci. 2018. 12,. 44
Mikiko Oka, Naoki Fujisaki, Akiko Maruko-Otake, Yosuke Ohtake, Sawako Shimizu, Taro Saito, Shin-Ichi Hisanaga, Koichi M. Iijima, Kanae Ando. Ca2+/calmodulin-dependent protein kinase II promotes neurodegeneration caused by tau phosphorylated at Ser262/356 in a transgenic Drosophila model of tauopathy. JOURNAL OF BIOCHEMISTRY. 2017. 162. 5. 335-342

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MISC (8)：

T Sasaki, M Taoka, K Ishiguro, A Uchida, T Saito, T Isobe, S Hisanaga. In vivo and in vitro phosphorylation at Ser-493 in the glutamate (E)-segment of neurofilament-H subunit by glycogen synthase kinase 3 beta. JOURNAL OF BIOLOGICAL CHEMISTRY. 2002. 277. 39. 36032-36039
ニューロフィラメントHサブユニットのGSK3βによるリン酸化. ジャーナルオブバイオロジカルケミストリー-J. Biol. Chem. 2002. 277, 36032-36039
CDK5:分裂しない神経細胞で機能するCDK. 実験医学. 2000. 18. 7. 878-883
Calpain-dependent proteolytic clearage of the p35 cyclin-dependent kinase 5 activator to p25. J. Biol. Chem. 2000. 275. 22. 17166-17172
K Ookata, S Hisanaga, M Sugita, A Okuyama, H Murofushi, H Kitazawa, S Chari, JC Bulinski, T Kishimoto. MAP4 is the in vivo substrate for CDC2 kinase in HeLa cells: Identification of an M-phase specific and a cell cycle-independent phosphorylation site in MAP4. BIOCHEMISTRY. 1997. 36. 50. 15873-15883

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Education (4)：

- 1982 The University of Tokyo
- 1982 The University of Tokyo Graduate School, Division of Natural Science
- 1975 The University of Tokyo Faculty of Science
The University of Tokyo Faculty of Science Department of Biophysics and Bio Chemistry

Professional career (1)：

Doctor(Science) (The University of Tokyo)

Work history (9)：

2018/04 - 現在 Tokyo Metropolitan University Graduate School of Science
2015/04 - 2018/03 Tokyo Metropolitan University Graduate School of Science and Engineering
1997/04 - 2015/03 Tokyo Metropolitan University Graduate School of Science
1990 - 1997 Tokyo Institute of Technology School of Bioscience and Biotechnology
1990 - 1997 Associate Professor, Tokyo Institute of

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Committee career (2)：

神経化学会評議員
細胞生物学会評議員

Association Membership(s) (6)：

International Society for Neurochemnistry , American Society for Biochemistry and Molecular Biology , American Society for Neuroscience , 生化学会 , 神経化学会 , 細胞生物学会

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