Rchr
J-GLOBAL ID：200901037962318818   Update date: Feb. 01, 2024

Okuda Kensuke

オクダ ケンスケ | Okuda Kensuke
Affiliation and department：
Kobe Pharmaceutical University

About Kobe Pharmaceutical University


Job title： Associate Professor
Homepage URL  (1)： http://www.kobepharma-u.ac.jp/edrs/faculty_member_list/organic_chemistry.html
Research field  (2)： Pharmaceuticals - chemistry and drug development ,  Pharmaceuticals - analytical and physicochemistry
Research keywords  (7)： florescent probes ,  Metallomics ,  Energy Metabolism ,  Stress Responce ,  hypoxia ,  cancer ,  heterocycles
Research theme for competitive and other funds  (27)：
  • 2022 - 2025 Development of MRI probes with signal amplification mechanism to elucidate zinc metabolism and dynamics
  • 2022 - 2024 強力ながんの栄養飢餓耐性解除能を有するカリストリロンOに基づくがん微小環境モジュレータの開発
  • 2021 - 2024 Development of near infrared cyanine dyes controlled by ring closing-opening system
  • 2022 - 2023 Exploratory study for the discovery of zinc homeostasis modulators utilizing a highly sensitive fluorescence imaging probe
  • 2022 - 2023 ストレス環境下でのがん細胞生存戦略の解明を可能とする単糖を基盤としたバイオプローブの創製
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Papers (100)：
  • Akira Takagi, Kazuki Usuguchi, Ippei Takashima, Kensuke Okuda. Development of 1,3,6-Tribenzoylated Glucose as an Antiausterity Agent Targeting Tumor Microenvironment. Chemical and Pharmaceutical Bulletin. 2023. 71. 8. 641-649
  • Kensuke Okuda, Ippei Takashima, Akira Takagi. Advances in reaction-based synthetic fluorescent probes for studying the role of zinc and copper ions in living systems. Journal of Clinical Biochemistry and Nutrition. 2023. 72. 1. 1-12
  • Harutoshi Matsumoto, Saeko Ando, Eri Yoshimoto, Takamasa Numano, Nahida Sultana, Katsumi Fukamachi, Munekazu Iinuma, Kensuke Okuda, Kazunori Kimura, Masumi Suzui. Extracts of Musa basjoo induce growth inhibition and changes in the protein expression of cell cycle control molecules in human colorectal cancer cell lines. Oncology Letters. 2022. 23. 3
  • Akira Takagi, Kazuki Usuguchi, Ippei Takashima, Kensuke Okuda. Total Synthesis of Antiausterity Agent (±)-Uvaridacol L by Regioselective Axial Diacylation of a myo-Inositol Orthoester. Organic Letters. 2021. 23. 11. 4083-4087
  • Takayuki Sakai, Yoshiyuki Matsuo, Kensuke Okuda, Kiichi Hirota, Mieko Tsuji, Tasuku Hirayama, Hideko Nagasawa. Development of antitumor biguanides targeting energy metabolism and stress responses in the tumor microenvironment. Scientific Reports. 2021. 11. 1. 4852-4852
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MISC (34)：
  • 永澤秀子, 境崇行, 小池晃太, 奥田健介, 平山祐, 辻美恵子. がん微小環境モジュレーターの創出をめざす創薬研究. 日本薬学会年会要旨集(CD-ROM). 2019. 139th
  • 境崇行, 小池晃太, 三木彩路, 横尾沙季, 平山祐, 奥田健介, 永澤秀子. がん微小環境標的ビグアニド誘導体の創薬研究. 日本薬学会年会要旨集(CD-ROM). 2017. 137th
  • 松本詩織, 境崇行, 奥田健介, 奥田健介, 永澤秀子, 平田洋子, 平田洋子, 大橋憲太郎, 大橋憲太郎. ヒト結腸癌細胞株HT29におけるグルコース欠乏性ストレス応答に対する新規フェンホルミン誘導体の効果に関する研究. 日本生化学会大会(Web). 2017. 90th
  • 境崇行, 辻美恵子, 平山祐, 奥田健介, 永澤秀子. がん微小環境における低栄養ストレス応答を標的とするビグアニド誘導体の創薬研究. メディシナルケミストリーシンポジウム講演要旨集. 2017. 35th
  • 大橋憲太郎, 大橋憲太郎, 境崇行, 奥田健介, 永澤秀子. ヒト結腸癌細胞HT29におけるグルコース欠乏性ストレス応答に対する新規フェンフォルミン誘導体の効果に関する研究. 日本がん分子標的治療学会学術集会プログラム・抄録集. 2016. 20th
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Patents (4)：
  • 新規化合物及び該化合物を含有する亜鉛検出用蛍光プローブ
  • In-vivo diagnostic and therapeutic compositions comprising fluorescent probe for hypoxia-associated ocular diseases
  • 低酸素領域イメージング用近赤外蛍光プロープ
  • 蛋白修飾物生成抑制剤および方法
Books (6)：
  • Inhibition of E. coli and Cancer Cell Growth by Fullerene Derivatives and the Inhibition Mechanism
    The Electrochemical Society, Inc. 2000
  • Inhibition of E. coli and Cancer Cell Growth by Fullerene Derivatives and the Inhibition Mechanism
    The Electrochemical Society 2000
  • Effects of Fullerene Derivatives on Active Oxygen Toxicity in E. coli
    The Electrochemical Society, Inc. 1997
  • Effects of Fullerene Derivatives on Active Oxygen Toxicity in E. coli
    The Electrochemical Society, Inc. 1997
  • Effects of a Fullerene Derivative, C<sub>60</sub>-dimalonic Acid, on Active Oxygen Toxicity
    The Electrochemical Society, Inc. 1996
ｍore...
Lectures and oral presentations  (4)：
  • がんの低酸素イメージング
    (第79回日本癌学会学術総会 2020)
  • がん微小環境ならびにストレス応答系に関するケミカルバイオロジー研究
    (第17回関西バイオ創薬研究会 2019)
  • がんのストレス応答系に関するケミカルバイオロジー研究
    (2016)
  • 近赤外蛍光プローブからみた癌増感のターゲット -低酸素-
    (第15回癌治療国際増感研究シンポジウム 2013)
Education (4)：
  • 1996 - 1998 The University of Tokyo Graduate School of Pharmaceutical Sciences
  • 1994 - 1996 The University of Tokyo Graduate School of Pharmaceutical Sciences
  • 1992 - 1994 The University of Tokyo Faculty of Pharmaceutical Sciences Department of Pharmacy
  • 1990 - 1992 The University of Tokyo College of Arts and Sciences
Professional career (1)：
  • Ph.D. (The University of Tokyo)
Work history (7)：
  • 2016/04 - 現在 Kobe Pharmaceutical University Laboratory of Bioorganic & Natural Products Chemistry Professor
  • 2012/04 - 2016/03 Laboratory of Medicinal and Pharmaceutical Chemistry, Gifu Pharmaceutical University Associate Professor
  • 2008/04 - 2012/03 Laboratory of Medicinal and Pharmaceutical Chemistry, Gifu Pharmaceutical University Associate Professor
  • 2007/04 - 2008/03 Division of Pharmaceutical Sciences, Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University Assistant Professor
  • 2002/04 - 2007/03 Laboratory of Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, Okayama University Research Associate
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Committee career (2)：
  • 2020/04 - 現在 International Association for the Sensitization of Cancer Treatment Administrator
  • 2016/04 - 現在 日本薬学会関西支部 委員
Awards (2)：
  • 2016/07 - 国際癌治療増感研究協会 協会賞
  • 2001/06 - 岡山工学振興会 科学技術賞
Association Membership(s) (8)：
Japan Pharmaceutical Association ,  International Association for the Sensitization of Cancer Treatment ,  Japanese Society for Molecular Imaging ,  The Japanese Association for Molecular Target Therapy of Cancer ,  The Pharmaceutical Society of Japan ,  American Association for Cancer Research ,  The Japanese Cancer Association ,  International Society of Heteroyclic Chemistry
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