Rchr
J-GLOBAL ID：200901038405075151
Update date: Jan. 30, 2024
Yuhki Koh-ichi
ユウキ コウイチ | Yuhki Koh-ichi
Affiliation and department：
Job title：
Associate Professor
Research field (5)：
Pharmacology
, Gastroenterology
, Urology
, Cardiology
, Molecular biology
Research keywords (2)：
薬理学一般
, Pharmacology
Research theme for competitive and other funds (21)：
- 2019 - 2023 プロスタグランジンD2の非アルコール性脂肪肝炎における役割の解明
- 2018 - 2021 Elucidation of the role of prostanoids in the development of liver fibrosis
- 2013 - 2015 Regulation of cardiac prostanoid synthesis by glucocorticoid and its pathophysiological meaning
- 2011 - 2013 The elucidation of the signal transduction system of ischemic myocardial protection of prostanoids
- 2011 - 2012 Roles of the prostanoids in the regulation of immunological responses
- 2010 - 2012 Role of prostanoids in the bone marrow derived endothelial cells
- 2010 - 2012 Roles of the prostanoids in the pathogenesis of cardiovascular diseases
- 2008 - 2010 The mechanism elucidation of the protective effect of prostanoids in ischemic myocardial protection
- 2007 - 2009 Roles of prostanoids in the pathogenesis of cardiovascular diseases
- 2006 - 2008 A study of the roles of prostanoids and its therapeutic application in cardiovascular remodeling
- 2005 - 2007 Roles of the prostanoids in the myocardial infarction and application to the treatment
- 2003 - 2005 A study of roles of the prostanoids in cardiovascular remodeling using mice lacking deficient in prostanoid receptors
- 2003 - 2004 受容体欠損マウスを用いた虚血-再灌流障害におけるプロスタグランジンE_2の役割解明
- 2002 - 2004 Roles of prostanoids in cardiovascular system revealed from studies using knockout mice
- 2002 - 2003 プロスタノイドの肝機能障害・肝再生におけるプロスタノイドの役割解明
- 2001 - 2002 心肥大・心不全における内因性プロスタノイドの役割の解明
- 1999 - 2000 心不全の心筋におけるエンドセリン産生の転写調節機構に関する分子生物学的研究
- 循環器系におけるプロスタノイドの役割の解明
- 心筋細胞の細胞障害に対する応答調節について
- Clarification of roles of prostanoids in cardiovascular system
- Response of Cardiomyocyte to Cellular Injury
Show all
Papers (45)：
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Fumiaki Kojima, Hiroki Sekiya, Yuka Hioki, Hitoshi Kashiwagi, Makoto Kubo, Masaki Nakamura, Shotaro Maehana, Yoshitaka Imamichi, Koh-ichi Yuhki, Fumitaka Ushikubi, et al. Facilitation of colonic T cell immune responses is associated with an exacerbation of dextran sodium sulfate-induced colitis in mice lacking microsomal prostaglandin E synthase-1. Inflammation and Regeneration. 2022. 42. 1
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Hitoshi Kashiwagi, Koh-ichi Yuhki, Yoshitaka Imamichi, Fumiaki Kojima, Shima Kumei, Yoshikazu Tasaki, Shuh Narumiya, Fumitaka Ushikubi. Prostaglandin F2α Facilitates Platelet Activation by Acting on Prostaglandin E2 Receptor Subtype EP3 and Thromboxane A2 Receptor TP in Mice. Thrombosis and Haemostasis. 2019. 119. 08. 1311-1320
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Takashi Yazawa, Yoshitaka Imamichi, Koh-Ichi Yuhki, Junsuke Uwada, Daisuke Mikami, Masayuki Shimada, Kaoru Miyamoto, Takeshi Kitano, Satoru Takahashi, Toshio Sekiguchi, et al. Cyclooxygenase-2 is acutely induced by CCAAT/enhancer-binding protein β to produce prostaglandin E2 and F2α following gonadotropin stimulation in Leydig cells. Molecular reproduction and development. 2019. 86. 7. 786-797
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Shima Kumei, Koh-Ichi Yuhki, Fumiaki Kojima, Hitoshi Kashiwagi, Yoshitaka Imamichi, Toshikatsu Okumura, Shuh Narumiya, Fumitaka Ushikubi. Prostaglandin I2 suppresses the development of diet-induced nonalcoholic steatohepatitis in mice. FASEB Journal. 2018. 32. 5. 2354-2365
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Yoshitaka Imamichi, Toshio Sekiguchi, Takeshi Kitano, Takashi Kajitani, Reiko Okada, Yoshihiko Inaoka, Kaoru Miyamoto, Junsuke Uwada, Satoru Takahashi, Takahiro Nemoto, et al. Diethylstilbestrol administration inhibits theca cell androgen and granulosa cell estrogen production in immature rat ovary. SCIENTIFIC REPORTS. 2017. 7
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MISC (109)：
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Hitoshi Kashiwagi, Koh-ichi Yuhki, Yoshitaka Imamichi, Fumiaki Kojima, Shima Kumei, Shuh Narumiya, Fumitaka Ushikubi. Prostaglandin F-2 alpha potentiates platelet aggregation via prostaglandin E-2 and thromboxane A(2) receptors. JOURNAL OF PHARMACOLOGICAL SCIENCES. 2017. 133. 3. S109-S109
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Hitoshi Kashiwagi, Koh-ichi Yuhki, Yoshitaka Imamichi, Fumiaki Kojima, Shima Kumei, Shuh Narumiya, Fumitaka Ushikubi. Promoting effect of prostaglandin F-2 alpha on platelet aggregation. JOURNAL OF PHARMACOLOGICAL SCIENCES. 2016. 130. 3. S172-S172
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結城 幸一, 柏木 仁, 今道 力敬, 中川 直樹, 藤野 貴行, 川辺 淳一, 牛首 文隆. 心脈管作動物質プロスタノイドの生体における役割 循環器疾患の病態形成におけるプロスタノイドの役割. 血管. 2016. 39. 1. 26-26
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Hitoshi Kashiwagi, Koh-ichi Yuhki, Fumiaki Kojima, Shima Kumei, Shuh Narumiya, Fumitaka Ushikubi. Cigarette smoke extract inhibits platelet aggregation. JOURNAL OF PHARMACOLOGICAL SCIENCES. 2015. 128. 3. S144-S144
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結城 幸一, 柏木 仁, 小島 史章, 今道 力敬, 牛首 文隆. 【プロスタグランジンによる病態制御の最前線】臓器線維化におけるプロスタノイドの役割. 細胞. 2015. 47. 6. 274-277
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Patents (1)：
Lectures and oral presentations (10)：
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Roles of the prostaglandin I-2-IP system in nonalcoholic steatohepatitis
(JOURNAL OF PHARMACOLOGICAL SCIENCES 2014)
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Thromboxane A(2) plays a critical role in reduction of the anti-platelet effect of prostaglandin I-2 receptor agonist beraprost after repeated administration
(JOURNAL OF PHARMACOLOGICAL SCIENCES 2014)
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Roles of the prostaglandin I-2-IP system in the development of nonalcoholic steatohepatitis
(JOURNAL OF PHARMACOLOGICAL SCIENCES 2013)
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Role of the prostaglandin E-2 receptor subtype EP1 in cisplatin-induced nephrotoxicity
(JOURNAL OF PHARMACOLOGICAL SCIENCES 2013)
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非アルコール性脂肪性肝炎の発症・進展におけるプロスタグランジンI2の役割解明
(日本薬理学雑誌 2013)
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Education (1)：
- - 1997 University of Tsukuba Master's Program in Medical Sciences
Professional career (2)：
- Master of medical science (University of Tsukuba)
- Ph.D. (Asahikawa Medical College)
Work history (5)：
- 2012 - 現在 Asahikawa Medical University School of Medicine
- 2006 - 2012 Asahikawa Medical University School of Medicine
- 2000 - 2012 筑波大学先端学際領域研究センター 客員研究員
- 2000 - 2006 Asahikawa Medical University School of Medicine
- 1998 - 2000 University of Tsukuba Institute of Clinical Medicine
Committee career (1)：
Association Membership(s) (3)：
日本循環器学会
, 日本生化学会
, 日本薬理学会
