Rchr
J-GLOBAL ID：200901038410215824   Update date: Apr. 01, 2024

UKIYA Motohiko

ウキヤ モトヒコ | UKIYA Motohiko
Affiliation and department：
Nihon University College of Science and Technology Department of Materials and Applied Chemistry

About Nihon University College of Science and Technology Department of Materials and Applied Chemistry


Job title： Professor
Research field  (4)： Pharmaceuticals - chemistry and drug development ,  Pharmaceuticals - chemistry and drug development ,  Bioorganic chemistry ,  Bioorganic chemistry
Research keywords  (14)： Degradation of targeting protein ,  terpenoid-amino acid conjugates ,  cytotoxity ,  synthesis of natural products derivatives ,  Natural Products ,  Terpenoid ,  triterpenoid ,  Compositae ,  Sunflower ,  Saponin ,  Bioactivity ,  Marigold ,  Lipid ,  Anti-Tumor Promotor
Research theme for competitive and other funds  (3)：
  • 2015 - 2017 抗がん剤の副作用低減を目指した天然物アミノ酸誘導体の合成
  • 2011 - 2011 Topoisomerase阻害テルペノイドの合理的設計と調製
  • 2010 - 2010 トポイソメラーゼ阻害を作用機序とするアポトーシス誘導型抗腫瘍化合物の合成
Papers (62)：
  • Atsuyoshi Nishina, Motohiko Ukiya, Kazuki Motegi, Risa Kiryu, Daisuke Sato, Mitsuru Sada, Yuki Hori, Hideo Satsu, Kazuhiro Uemura, Mamoru Koketsu, et al. Promotion of ABCG2 gene expression by neolignans from Piper longum L. Bioscience, Biotechnology, and Biochemistry. 2023. in press
  • Motohiko Ukiya, Tomoyuki Sekine, Naoto Shimizu, Hiroyuki Akazawa, Minoru Tanigawa, Yusuke Suzuki, Atsuyoshi Nishina. Amino Acid Conjugates of ent-Beyerane-type Diterpenoids and Oleanane-type Triterpenoids : Synthesis and Evaluation of Cytotoxic Activities. JOURNAL OF OLEO SCIENCE. 2023. 72. 4. 461-472
  • Shoko Matsushita, Kazuhiko Noda, Shuta Hara, Jumpei Aisu, Aki Hayashi, Hiroki Ikake, Shigeru Shimizu, Minoru Tanigawa, Motohiko Ukiya, Katsushi Nishimura, et al. Rapid removal of detergent in glycolipids using ionic liquids. Analytical Sciences. 2022. 38. 8. 1115-1121
  • Ukiya, Motohiko; Motegi, Kazuki; Sato, Daisuke; Kimura, Hirokazu; Satsu, Hideo; Koketsu, Mamoru; Ninomiya, Masayuki; Myint, Lwin Mon; Nishina, Atsuyoshi. Effect of Compounds from Moringa oleifera Lam. on in Vitro Non-Alcoholic Fatty Liver Disease (NAFLD),Model System. Chemistry & Biodiversity. 2021. 18. 7. e2100243
  • Zhang, Bo-dou; Zhu, Wan-fang; Akihisa, Toshihiro; Kikuchi, Takashi; Ukiya, Motohiko; Maya, Fukuda; Xu, Jian; Liu, Wen-yuan;, Feng, et al. Cardiac glycosides from the roots of Streblus asper Lour. and their apoptosis-inducing activities in,A549 cells. Phytochemistry. 2021. 181. 112544
ｍore...
MISC (8)：
  • A. Nishina, M. Ukiya, M. Fukatsu, M. Koketsu, M. Ninomiya, D. Sato, H. Kimura. 5,7-Dihydroxyflavone analogues may regulate lipopolysaccharide-induced inflammatory responses by suppressing I kappa B alpha-linked Akt and ERK5 phosphorylation in RAW 264.7 macrophages. PLANTA MEDICA. 2016. 82
  • T Akihisa, S Mafune, M Ukiya, Y Kimura, K Yasukawa, T Suzuki, H Tokuda, N Tanabe, T Fukuoka. (+)- and (-)-syn-2-isobutyl-4-methylazetidine-2,4-dicarboxylic acids from the extract of Monascus pilosus-fermented rice (red-mold rice). (vol 67, pg 479, 2004). JOURNAL OF NATURAL PRODUCTS. 2005. 68. 9. 1444-1444
  • Y.Mizushina, T.Akihisa, M.Ukiya, C.Murakami, I.Kuriyama, X.Xu, H.Yoshida, K.Sakaguchi. Selective inhibition of the activities of both DNA polymerases and DNA topoisomerase II by lanostane-type triterpene acids from Poria cocos. Cancer Sci. 2004. 95. 4. 354-360
  • T Akihisa, Y Takamine, K Yoshizumi, H Tokuda, Y Kimura, M Ukiya, T Nakahara, T Yokochi, E Ichiishi, H Nishino. Microbial transformations of two lupane-type triterpenes and anti-tumor-promoting effects of the transformation products. JOURNAL OF NATURAL PRODUCTS. 2002. 65. 3. 278-282
  • 秋久 俊博, Jun Ogihara, Jun Kato, Ken Yasukawa, Motohiko Ukiya, Sake Yamanouchi, Kunio Oishi. Inhibitory Effects of Triterpenoids and Sterols on Human Immunodeficiency Virus-1 Reverse Transcriptase. Lipids. 2001. 36. 5. 507-512
ｍore...
Patents (4)：
  • 発癌予防剤
  • 発癌予防剤
  • 悪性腫瘍治療薬
  • Agent for treatment of malignant tumor
Books (1)：
  • 資源天然物化学 改訂版
    共立出版 2017 ISBN:9784320044524
Lectures and oral presentations  (39)：
  • トリテルペノイドを用いたPROTACsの合成および腫瘍細胞傷害活性
    (日本薬学会第142年会 2022)
  • がん治療薬開発を目指したタンパク質分解分子の合成
    (第65回日本大学理工学部学術講演会 2021)
  • トリテルペノイド由来α-アミノ酸合成および腫瘍細胞傷害活性
    (日本薬学会第139年会 2019)
  • ジテルペノイド-アミノ酸結合体の合成および腫瘍細胞傷害活性
    (日本薬学会第139年会 2019)
  • オレアナン型トリテルペノイド-アミノ酸結合体の合成および腫瘍細胞傷害活性
    (日本薬学会第139年会 2019)
ｍore...
Education (2)：
  • - 1999 Nihon University Graduate School, Division of Science and Engineering 工業化学専攻
  • - 1997 Nihon University Faculty of Science and Engineering 工業化学科
Association Membership(s) (6)：
日本フードファクター学会 ,  がん予防研究会 ,  日本生薬学会 ,  'Japan Society for Bioscience, Biotechnology, and Agrochemistry' ,  Japan Oil Chemists' Society ,  Pharmaceutical Society of Japan
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