Rchr

J-GLOBAL ID：200901038450124309 Update date: Oct. 23, 2023

Hashimoto Shigeki

ハシモトシゲキ | Hashimoto Shigeki

Affiliation and department：
Job title： Lecturer

Research field (1)： Biochemistry

Research keywords (1)： Antibacterial peptide

Research theme for competitive and other funds (2)：

抗菌ペプチドの機能改変に関する研究
Studies on the engineering of antibacterial peptides

Papers (22)：

Ken'ichiro Matsumoto, Kurato Yamazaki, Shun Kawakami, Daichi Miyoshi, Toshihiko Ooi, Shigeki Hashimoto, Seiichi Taguchi. In vivo target exploration of apidaecin based on Acquired Resistance induced by Gene Overexpression (ARGO assay). SCIENTIFIC REPORTS. 2017. 7. 12136
Satoko Matsumura, Keiko Shinoda, Mayumi Yamada, Satoshi Yokojima, Masafumi Inoue, Takayuki Ohnishi, Tetsuya Shimada, Kazuya Kikuchi, Dai Masui, Shigeki Hashimoto, et al. Two Distinct Amyloid beta-Protein (A beta) Assembly Pathways Leading to Oligomers and Fibrils Identified by Combined Fluorescence Correlation Spectroscopy, Morphology, and Toxicity Analyses. JOURNAL OF BIOLOGICAL CHEMISTRY. 2011. 286. 13. 11555-11562
Ken'ichiro Matsumoto, Yoshitake Orikasa, Kenta Ichinohe, Shigeki Hashimoto, Toshihiko Ooi, Seiichi Taguchi. Flow cytometric analysis of the contributing factors for antimicrobial activity enhancement of cell-penetrating type peptides: Case study on engineered apidaecins. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2010. 395. 1. 7-10
Shigeki Hashimoto, Seiichi Taguchi. Activity improvement of antimicrobial peptides by a chemical modification approach: Toward the creation of novel types of antimicrobial agents. Mini-Reviews in Organic Chemistry. 2010. 7. 4. 282-289
Kazuya Kikuchi, Shigeki Hashimoto, Shin Mizukami, Tetsuo Nagano. Anion Sensor-Based Ratiometric Peptide Probe for Protein Kinase Activity. ORGANIC LETTERS. 2009. 11. 13. 2732-2735

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MISC (7)：

橋本茂樹. 未来を拓くケミカルバイオロジー -細胞内反応を可視化する蛍光プローブの開発-. 東京理科大学科学フォーラム. 2006. 23. 4. 42-43
橋本茂樹,菊地和也. 励起波長がレシオ的に変化するリン酸化蛍光プローブの開発. さきがけ研究21タイムシグナルと制御報告会要旨集. 2004. 91
Shigeki Hashimoto, Kazuo Yamamoto, Yushin Nakamura. DNA cleavage properties of bis(N-methylpyrrole oligopeptide-linked hydroxamic acid)-transition metal complexes. Nucleic Acids Symposium Series. 1998. 39. 37-38
Shigeki Hashimoto, Kazuto Itai, Yumiko Takeuchi, Yushin Nakamura. Synthesis of bisnetropsin-linked hydroxamic acids and their DNA cleavage properties in the presence of transition or lanthanide metal ions. Nucleic Acids Symposium Series. 1997. 37. 7-8
Shigeki Hashimoto, Shingo Ito, Yushin Nakamura. DNA cleavage by distamycin-linked hydroxamic acid-lanthanide and transition metal complexes. Nucleic Acids Symposium Series. 1996. 35. 65-66

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Books (9)：

2022年度版基礎工学実験
学術図書出版 2022 ISBN:9784780610062
2021年度版基礎工学実験
学術図書出版 2021 ISBN:9784780609301
2020年度版基礎工学実験
学術図書出版社 2020 ISBN:9784780608120
2019年度版基礎工学実験
学術図書出版社 2019 ISBN:9784780607482
2018年度版基礎工学実験
学術図書出版 2018

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Lectures and oral presentations (44)：

昆虫由来抗菌ペプチドの高活性化と作用機序解明のための新アプローチ
(第69回日本生物工学会大会 2017)
抗菌ペプチド・アピデシンおよび高活性変異体の作用機構解析
(第69回日本生物工学会大会 2017)
抗菌ペプチド「タナチン」の変異体作製とその機能評価
(高分子学会北海道支部若手研究会 2014)
抗菌スペクトルを改変した抗菌ペプチド「アピデシン」特殊変異体の創成とその抗菌活性
(高分子学会北海道支部若手研究会 2014)
抗菌スペクトルを改変した抗菌ペプチド「アピデシン」特殊変異体の創成とその抗菌活性
(日本農芸化学会北海道支部夏季シンポジウム 2013)

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Education (2)：

- 1996 Tokyo University of Science Graduate School, Division of Engineering Science
- 1992 Tokyo University of Science Faculty of Engineering Science Department of Biological Science and Technology

Professional career (1)：

Ph. D. (Tokyo University of Science)

Work history (3)：

2002 - 2005 PRESTO, JST Research Associate
1999 - 2002 Department of Chemistry, University of Virginia Research Associate
1996 - 1999 Faculty of Engineering Science, Tokyo University of Science Research Assitant

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